2019
Real‐Time Imaging of Vaccine Biodistribution Using Zwitterionic NIR Nanoparticles
Katagiri W, Lee J, Tétrault M, Kang H, Jeong S, Evans C, Yokomizo S, Santos S, Jones C, Hu S, Fakhri G, Tsukada K, Choi H, Kashiwagi S. Real‐Time Imaging of Vaccine Biodistribution Using Zwitterionic NIR Nanoparticles. Advanced Healthcare Materials 2019, 8: e1900035. PMID: 31165556, PMCID: PMC6687515, DOI: 10.1002/adhm.201900035.Peer-Reviewed Original ResearchConceptsNIR fluorescence imaging systemLymph nodesVaccine antigensClinical vaccine candidatesOptimization of vaccine designFluorescence imaging systemAntigen presenting cellsInduce protective immune responsesSecondary lymphoid tissuesDelivery of vaccine antigensProtective immune responsesZwitterionic NIR fluorophoreFlow cytometry analysisPresenting cellsLymphoid tissueIntradermal administrationAdverse reactionsBioconjugate vaccineImmune responseVaccine designVaccine candidatesModel vaccineCytometry analysisZwitterionic fluorophoresAntigen
2018
Heat-induced radiolabeling and fluorescence labeling of Feraheme nanoparticles for PET/SPECT imaging and flow cytometry
Yuan H, Wilks M, Normandin M, El Fakhri G, Kaittanis C, Josephson L. Heat-induced radiolabeling and fluorescence labeling of Feraheme nanoparticles for PET/SPECT imaging and flow cytometry. Nature Protocols 2018, 13: 392-412. PMID: 29370158, PMCID: PMC5966297, DOI: 10.1038/nprot.2017.133.Peer-Reviewed Original Research
2016
Site‐Specific In Vivo Bioorthogonal Ligation via Chemical Modulation
Koo H, Lee J, Bao K, Wu Y, Fakhri G, Henary M, Yun S, Choi H. Site‐Specific In Vivo Bioorthogonal Ligation via Chemical Modulation. Advanced Healthcare Materials 2016, 5: 2510-2516. PMID: 27568818, PMCID: PMC5541365, DOI: 10.1002/adhm.201600574.Peer-Reviewed Original ResearchConceptsClick chemistryClick moietyEfficiency of click chemistryLow reaction efficiencyIn vivo click chemistryReaction efficiencyChemical structureBioorthogonal ligationMoietyChemistryBioorthogonal click chemistryNear-infrared fluorophoreChemical modulatorsSurface chargeTetrazinePharmacokinetic barriersLipophilicityControlled pharmacokineticsFluorophoresTissue-Specific Near-Infrared Fluorescence Imaging
Owens E, Henary M, Fakhri G, Choi H. Tissue-Specific Near-Infrared Fluorescence Imaging. Accounts Of Chemical Research 2016, 49: 1731-1740. PMID: 27564418, PMCID: PMC5776714, DOI: 10.1021/acs.accounts.6b00239.Peer-Reviewed Original ResearchMeSH KeywordsContrast MediaFluorescenceFluorescent DyesHumansInfrared RaysNanoconjugatesNeoplasmsTissue DistributionConceptsSingle-photon emission computed tomographyPositron emission tomographyVital tissuesReal-time intraoperative navigationReal-time image guidanceContrast agentsTargeted NIR fluorophoresEmission computed tomographyTissue-specific contrast agentsEffective imaging agentsTissue-specific targetingReal-time delineationIntraoperative successTargeted therapyImage guidanceTumor tissuesEPR effectIntraoperative navigationSurgical fieldClinical imaging technologyDiagnostic utilityClinical useEmission tomographySurgical spaceTarget tissuesEndocrine-specific NIR fluorophores for adrenal gland targeting
Ashitate Y, Levitz A, Park M, Hyun H, Venugopal V, Park G, Fakhri G, Henary M, Gioux S, Frangioni J, Choi H. Endocrine-specific NIR fluorophores for adrenal gland targeting. Chemical Communications 2016, 52: 10305-10308. PMID: 27476533, PMCID: PMC4982771, DOI: 10.1039/c6cc03845j.Peer-Reviewed Original ResearchRenal Clearable Organic Nanocarriers for Bioimaging and Drug Delivery
Kang H, Gravier J, Bao K, Wada H, Lee J, Baek Y, Fakhri G, Gioux S, Rubin B, Coll J, Choi H. Renal Clearable Organic Nanocarriers for Bioimaging and Drug Delivery. Advanced Materials 2016, 28: 8162-8168. PMID: 27414255, PMCID: PMC5155334, DOI: 10.1002/adma.201601101.Peer-Reviewed Original Research