Neurogenetic contributions to amyloid beta and tau spreading in the human cortex
Sepulcre J, Grothe M, d’Oleire Uquillas F, Ortiz-Terán L, Diez I, Yang H, Jacobs H, Hanseeuw B, Li Q, El-Fakhri G, Sperling R, Johnson K. Neurogenetic contributions to amyloid beta and tau spreading in the human cortex. Nature Medicine 2018, 24: 1910-1918. PMID: 30374196, PMCID: PMC6518398, DOI: 10.1038/s41591-018-0206-4.Peer-Reviewed Original ResearchConceptsAmyloid-betaGenetic profileIdentified distinct pathwaysTau positron emission tomography imagingTau propagationTau pathwayTau spreadingGenetic backgroundAllen Human Brain AtlasDistinct pathwaysAlzheimer's diseaseTauLipid metabolismAb accumulationAdult individualsPathwayHuman Brain AtlasPathological progressionTranscriptomeMechanisms of pathological progressionBetaAmyloidProteinopathiesNeuronal circuitsApoSequence Alterations of Cortical Genes Linked to Individual Connectivity of the Human Brain
Xin Q, Ortiz-Terán L, Diez I, Perez D, Ginsburg J, Fakhri G, Sepulcre J. Sequence Alterations of Cortical Genes Linked to Individual Connectivity of the Human Brain. Cerebral Cortex 2018, 29: 3828-3835. PMID: 30307489, PMCID: PMC6686751, DOI: 10.1093/cercor/bhy262.Peer-Reviewed Original ResearchConceptsGenetic sequence alterationsGene expression profilesSequence alterationsGenetic expression dataExpression profilesBrain regionsFunctional connectivity variabilityCortical genesCortical regionsAllen Brain AtlasExpression dataGenetic variationGenetic signaturesFunctional connectivity magnetic resonance imagingCortical areasDiscrete cortical regionsGenesGraph theory analysisFunctional profilesNeurobiological underpinningsSequenceDegree of individual variabilityBrain areasBrain individualizationBrain organization