2017
Heat-induced-radiolabeling and click chemistry: A powerful combination for generating multifunctional nanomaterials
Yuan H, Wilks M, Fakhri G, Normandin M, Kaittanis C, Josephson L. Heat-induced-radiolabeling and click chemistry: A powerful combination for generating multifunctional nanomaterials. PLOS ONE 2017, 12: e0172722. PMID: 28225818, PMCID: PMC5321420, DOI: 10.1371/journal.pone.0172722.Peer-Reviewed Original ResearchConceptsClick reactionClick chemistryCopper-free click reactionCopper-catalyzedAzide groupsBiomolecule attachmentReporter groupNP surfaceTargeted nanoparticlesNanoparticlesBioactive groupsMultifunctional nanomaterialsBiomedical applicationsSynthesisIntermediateReactionChemistryNanomaterialsBiomoleculesAlkynesCombination of techniquesCell surface receptorsAzideTherapeutic agentsClick
2016
Site‐Specific In Vivo Bioorthogonal Ligation via Chemical Modulation
Koo H, Lee J, Bao K, Wu Y, Fakhri G, Henary M, Yun S, Choi H. Site‐Specific In Vivo Bioorthogonal Ligation via Chemical Modulation. Advanced Healthcare Materials 2016, 5: 2510-2516. PMID: 27568818, PMCID: PMC5541365, DOI: 10.1002/adhm.201600574.Peer-Reviewed Original ResearchConceptsClick chemistryClick moietyEfficiency of click chemistryLow reaction efficiencyIn vivo click chemistryReaction efficiencyChemical structureBioorthogonal ligationMoietyChemistryBioorthogonal click chemistryNear-infrared fluorophoreChemical modulatorsSurface chargeTetrazinePharmacokinetic barriersLipophilicityControlled pharmacokineticsFluorophores