2023
Longitudinal Imaging in a Patient With Opioid-associated Amnestic Syndrome
Barash J, Schmahmann J, Xie Z, Lev M, Fakhri G. Longitudinal Imaging in a Patient With Opioid-associated Amnestic Syndrome. Cognitive And Behavioral Neurology 2023, 36: 194-197. PMID: 37389894, PMCID: PMC10527331, DOI: 10.1097/wnn.0000000000000347.Peer-Reviewed Original ResearchConceptsOpioid-associated amnestic syndromeFluid-attenuated inversion recoveryPositron emission tomographyAmnestic syndromeHistory of attention-deficit hyperactivity disorderAttention-deficit hyperactivity disorderBrain regions of individualsSubstance use disordersOpioid misuseMild memory lossN-acetyl aspartate/creatineUrine toxicology screenFollow-up imagingHistory of opioid misuseRegions of individualsTau depositionTau positron emission tomographyHyperactivity disorderIntravenous heroinRight hippocampusAnterograde amnesiaRestricted diffusionBrain regionsHippocampal abnormalitiesLongitudinal imaging
2022
A multi-pronged investigation of option generation using depression, PET and modafinil
Ang Y, Cusin C, Petibon Y, Dillon D, Breiger M, Belleau E, Normandin M, Schroder H, Boyden S, Hayden E, Levine M, Jahan A, Meyer A, Kang M, Brunner D, Gelda S, Hooker J, Fakhri G, Fava M, Pizzagalli D. A multi-pronged investigation of option generation using depression, PET and modafinil. Brain 2022, 145: 1854-1865. PMID: 35150243, PMCID: PMC9166534, DOI: 10.1093/brain/awab429.Peer-Reviewed Original ResearchConceptsD2/D3 receptor availabilitySelf-generated optionsDepressive disorderDepressed individualsReceptor availabilityDopamine D2/D3 receptor availabilityNon-depressed adultsEffects of modafinilPutamen of patientsAssociated with uniquenessOption generationD2/D3 receptorsDopaminergic activityClinical depressionBinding potentialModafinilHealthy participantsPutamenPlacebo-controlledSamples of healthy peopleDouble-blindDisordersSelf-generationHealthy controlsDopamine
2019
Assessment of Striatal Dopamine Transporter Binding in Individuals With Major Depressive Disorder
Pizzagalli D, Berretta S, Wooten D, Goer F, Pilobello K, Kumar P, Murray L, Beltzer M, Boyer-Boiteau A, Alpert N, Fakhri G, Mechawar N, Vitaliano G, Turecki G, Normandin M. Assessment of Striatal Dopamine Transporter Binding in Individuals With Major Depressive Disorder. JAMA Psychiatry 2019, 76: 854-861. PMID: 31042280, PMCID: PMC6495358, DOI: 10.1001/jamapsychiatry.2019.0801.Peer-Reviewed Original ResearchConceptsMajor depressive disorderDA transporter availabilityVentral tegmental areaDA transporterDAT availabilityTegmental areaDepressive disorderDA signalingPositron emission tomographyDAT expressionMcLean HospitalHealthy controlsMajor depressive disorder groupsNumbers of depressive episodesStriatal dopamine transporter bindingDA transporter levelsLevels of DAT expressionStriatal DAT expressionStriatal DAT availabilityDA transporter densityDAT binding potentialDopamine transporter bindingOlder healthy controlsMesolimbic pathwayDA clearance
2017
Frontostriatal and Dopamine Markers of Individual Differences in Reinforcement Learning: A Multi-modal Investigation
Kaiser R, Treadway M, Wooten D, Kumar P, Goer F, Murray L, Beltzer M, Pechtel P, Whitton A, Cohen A, Alpert N, Fakhri G, Normandin M, Pizzagalli D. Frontostriatal and Dopamine Markers of Individual Differences in Reinforcement Learning: A Multi-modal Investigation. Cerebral Cortex 2017, 28: 4281-4290. PMID: 29121332, PMCID: PMC6454484, DOI: 10.1093/cercor/bhx281.Peer-Reviewed Original ResearchConceptsDA transporterRL behaviourVentral striatumDA clearanceFunctional connectivityBinding potentialLevel of neurocognitive functioningIncreased intrinsic functional connectivityMulti-modal neuroimaging studiesResting-state functional connectivityPhasic DA activityStriatal DA transporterIntrinsic functional connectivityReinforcement learning behaviorMulti-modal investigationsFrontostriatal circuitsFrontostriatal connectivityFrontostriatal regionsOrbitofrontal cortexDA activityNeuroimaging studiesOrbitofrontal regionsDopamine markersNeurocognitive functionDopamine
2015
Pulmonary imaging using respiratory motion compensated simultaneous PET/MR
Dutta J, Huang C, Li Q, El Fakhri G. Pulmonary imaging using respiratory motion compensated simultaneous PET/MR. Medical Physics 2015, 42: 4227-4240. PMID: 26133621, PMCID: PMC4474958, DOI: 10.1118/1.4921616.Peer-Reviewed Original ResearchConceptsRespiratory motionContrast-to-noise ratioClinical patient studiesPulse sequenceHigh-intensity featuresXCAT studyLow proton densityXCAT simulationPatient studiesXCAT phantomAttenuation mapBiograph mMRComplete data acquisitionSimultaneous PET/MRNonrigid registrationPET/MR scannersPET/magnetic resonanceMagnetic susceptibilityProton densityQuantitative accuracyRelaxation timePulmonary imagingLung lesionsBlurring artifactsDeformation field
2014
Evaluating Structural Symmetry of Weighted Brain Networks via Graph Matching
Hu C, El Fakhri G, Li Q. Evaluating Structural Symmetry of Weighted Brain Networks via Graph Matching. Lecture Notes In Computer Science 2014, 17: 733-740. PMID: 25485445, DOI: 10.1007/978-3-319-10470-6_91.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderNetwork symmetryBrain networksType of Attention Deficit Hyperactivity DisorderWeighted brain networksConsistent with former findingsDeficit hyperactivity disorderRs-fMRI networksResting state fMRISymmetry levelInattentive typeHyperactivity disorderBrain areasSymmetryStructural symmetryBrain connectivityFunctional networksResting stateLarger thresholdsBrainFMRIHigher levelsGraph matchingNode pairsNormal subjects
2013
Clinical Application of In-Room Positron Emission Tomography for In Vivo Treatment Monitoring in Proton Radiation Therapy
Min C, Zhu X, Winey B, Grogg K, Testa M, Fakhri G, Bortfeld T, Paganetti H, Shih H. Clinical Application of In-Room Positron Emission Tomography for In Vivo Treatment Monitoring in Proton Radiation Therapy. International Journal Of Radiation Oncology • Biology • Physics 2013, 86: 183-189. PMID: 23391817, PMCID: PMC3640852, DOI: 10.1016/j.ijrobp.2012.12.010.Peer-Reviewed Original ResearchConceptsIn-room positron emission tomographyProton therapyIn-roomPositron emission tomography scanIn-room PET scannerPassive scattering proton therapyShapes of target volumesPositron emission tomographyMC predictionBeam range uncertaintiesMeasured PET imagesMonte CarloProton radiation therapyLocal elemental compositionBiological washoutScan timeTreatment headTreatment verificationRange uncertaintiesTarget volumePET scan timePET scannerPET systemComputed tomographyMC results
2012
Parametric imaging with Bayesian priors: A validation study with 11C-Altropane PET
Fang Y, Fakhri G, Becker J, Alpert N. Parametric imaging with Bayesian priors: A validation study with 11C-Altropane PET. NeuroImage 2012, 61: 131-138. PMID: 22425668, DOI: 10.1016/j.neuroimage.2012.03.003.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAlgorithmsBayes TheoremBiasCarbon RadioisotopesCocaineData Interpretation, StatisticalFemaleHumansImage Processing, Computer-AssistedKineticsLeast-Squares AnalysisMaleMiddle AgedNeuroimagingNonlinear DynamicsNormal DistributionPopulationPositron-Emission TomographyRadiopharmaceuticalsReference ValuesSample SizeYoung Adult