2021
Detecting lumbar lesions in 99mTc‐MDP SPECT by deep learning: Comparison with physicians
Petibon Y, Fahey F, Cao X, Levin Z, Sexton‐Stallone B, Falone A, Zukotynski K, Kwatra N, Lim R, Bar‐Sever Z, Chemli Y, Treves S, Fakhri G, Ouyang J. Detecting lumbar lesions in 99mTc‐MDP SPECT by deep learning: Comparison with physicians. Medical Physics 2021, 48: 4249-4261. PMID: 34101855, DOI: 10.1002/mp.15033.Peer-Reviewed Original ResearchMeSH KeywordsChildDeep LearningHumansPhysiciansRetrospective StudiesTechnetium Tc 99m MedronateTomography, Emission-Computed, Single-PhotonConceptsSingle-photon emission computed tomographyLow back painLumbar lesionsPediatric patientsTc-MDPEvaluate low back painCause of low back painTc-MDP scanLesion-presentEmission computed tomographyConvolutional neural networkClinical likelihoodBack painInterreader variabilityDeep convolutional neural networkLumbar locationLesionsStress lesionsFocal lesionsDeep learningPatientsLumbar stressPhysiciansDL systemsLROC studies
2018
Joint reconstruction of rest/stress myocardial perfusion SPECT
Lai X, Petibon Y, Fakhri G, Ouyang J. Joint reconstruction of rest/stress myocardial perfusion SPECT. Physics In Medicine And Biology 2018, 63: 135019. PMID: 29897044, PMCID: PMC6245543, DOI: 10.1088/1361-6560/aacc2f.Peer-Reviewed Original ResearchMeSH KeywordsHumansImage Processing, Computer-AssistedModels, TheoreticalMyocardial Perfusion ImagingMyocardiumPhantoms, ImagingSignal-To-Noise RatioTomography, Emission-Computed, Single-PhotonConceptsMyocardial perfusion imagingSingle photon emission computed tomographyReversible defectsSignal-to-noise ratioRest/stress SPECT myocardial perfusion imagingSPECT myocardial perfusion imagingConventional subtraction methodDefect detectionJoint methodPhoton emission computed tomographySubtraction methodReverse mappingClinical dose levelsEmission computed tomographyImprove defect detectionLow noiseNon-invasive assessmentClinical dosePerfusion defectsReduced doseImprove radiologists' performanceReconstruction frameworkRest imagesPerfusion imagingDose levelsHeat-induced radiolabeling and fluorescence labeling of Feraheme nanoparticles for PET/SPECT imaging and flow cytometry
Yuan H, Wilks M, Normandin M, El Fakhri G, Kaittanis C, Josephson L. Heat-induced radiolabeling and fluorescence labeling of Feraheme nanoparticles for PET/SPECT imaging and flow cytometry. Nature Protocols 2018, 13: 392-412. PMID: 29370158, PMCID: PMC5966297, DOI: 10.1038/nprot.2017.133.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsFerrosoferric OxideFlow CytometryFluorescenceFluorescent DyesHot TemperatureHumansIron RadioisotopesMagnetic Resonance ImagingNanoparticlesOptical ImagingPositron-Emission TomographyRadiopharmaceuticalsTomography, Emission-Computed, Single-Photon
2017
Joint reconstruction of Ictal/inter‐ictal SPECT data for improved epileptic foci localization
Rakvongthai Y, Fahey F, Borvorntanajanya K, Tepmongkol S, Vutrapongwatana U, Zukotynski K, Fakhri G, Ouyang J. Joint reconstruction of Ictal/inter‐ictal SPECT data for improved epileptic foci localization. Medical Physics 2017, 44: 1437-1444. PMID: 28211105, PMCID: PMC5462456, DOI: 10.1002/mp.12167.Peer-Reviewed Original ResearchMeSH KeywordsEpilepsies, PartialHumansImage Processing, Computer-AssistedPhantoms, ImagingSignal-To-Noise RatioSubtraction TechniqueTomography, Emission-Computed, Single-PhotonConceptsSPECT reconstruction methodDifferential imagingLow-noise datasetConventional subtraction methodLesion contrastSPECT projection dataEpileptic focus localizationHoffman phantomPatient studiesReconstruction methodJoint methodSPECT projectionsHead phantomPhantom locationsSubtraction methodPhantom studyNuclear medicine physiciansAttenuation backgroundPhantomConventional subtraction approachFocus localizationConventional subtractionReceiver operating characteristicLow noiseProjection data
2016
Novel laser‐processed CsI:Tl detector for SPECT
Sabet H, Bläckberg L, Uzun-Ozsahin D, El-Fakhri G. Novel laser‐processed CsI:Tl detector for SPECT. Medical Physics 2016, 43: 2630-2638. PMID: 27147372, PMCID: PMC5148208, DOI: 10.1118/1.4947294.Peer-Reviewed Original ResearchConceptsOptical barrierPeak-to-valley (P/VCsI:Tl crystalsCrystal bulkMultipixel photon counterPixel-like patternScintillation lightEnergy resolutionKeV gammasPixelated scintillatorScintillator samplesPhoton counterTL detectorsTl crystalsFabricated detectorScintillationCrystal thicknessSpatial resolutionPixel arrayDetectorBarrier patternsFabricated arraysCSICrystalBulk
2013
Simultaneous 99mTc‐MDP/123I‐MIBG tumor imaging using SPECT‐CT: Phantom and constructed patient studies
Rakvongthai Y, Fakhri G, Lim R, Bonab A, Ouyang J. Simultaneous 99mTc‐MDP/123I‐MIBG tumor imaging using SPECT‐CT: Phantom and constructed patient studies. Medical Physics 2013, 40: 102506. PMID: 24089927, PMCID: PMC3785531, DOI: 10.1118/1.4820977.Peer-Reviewed Original ResearchMeSH Keywords3-IodobenzylguanidineAlgorithmsHumansImage Processing, Computer-AssistedMonte Carlo MethodMultimodal ImagingNeoplasmsPhantoms, ImagingTechnetium Tc 99m MedronateTime FactorsTomography, Emission-Computed, Single-PhotonTomography, X-Ray ComputedConceptsScatter correctionDual-radionuclideContrast recoveryPhantom studyAnthropomorphic torso phantomPatient studiesTumor uptakeTumor imagingSPECT projectionsTorso phantomMonte-CarloPhantom dataPhantomIterative reconstructionOSEMProjection dataDR dataIncrease patient throughputNoise realizationsSPECT-CTImage reconstructionClinical studiesTumorTumor projectionPoisson noise
2010
Dual-Radionuclide Brain SPECT for the Differential Diagnosis of Parkinsonism
El Fakhri G, Ouyang J. Dual-Radionuclide Brain SPECT for the Differential Diagnosis of Parkinsonism. Methods In Molecular Biology 2010, 680: 237-246. PMID: 21153385, DOI: 10.1007/978-1-60761-901-7_16.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsBrainDiagnosis, DifferentialDopamineHumansImage Processing, Computer-AssistedMonte Carlo MethodNeural Networks, ComputerOrganotechnetium CompoundsParkinsonian DisordersTomography, Emission-Computed, Single-PhotonTropanesConceptsDopamine transporter functionBrain SPECTDifferential diagnosis of parkinsonismDifferential diagnosisDiagnosis of parkinsonismIdiopathic Parkinson's diseaseDifferential diagnosis of idiopathic Parkinson’s diseaseDiagnosis of idiopathic Parkinson's diseaseCorticobasal degenerationProgressive supranuclear palsyParkinson's diseaseMultiple system atrophyParkinsonSPECT protocol
2009
Quantitative simultaneous cardiac SPECT using MC‐JOSEM
Ouyang J, Zhu X, Trott C, Fakhri G. Quantitative simultaneous cardiac SPECT using MC‐JOSEM. Medical Physics 2009, 36: 602-611. PMID: 19292000, PMCID: PMC2673670, DOI: 10.1118/1.3063544.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsFatty AcidsHeartImage Processing, Computer-AssistedIodobenzenesMonte Carlo MethodPhantoms, ImagingSensitivity and SpecificityTechnetium Tc 99m SestamibiTime FactorsTomography, Emission-Computed, Single-PhotonTomography, X-Ray ComputedConceptsMC-JOSEMEnergy windowWater-filled torso phantomScatter correctionPhotopeak energy windowStandard OSEMCardiac SPECT imagingActivity concentration ratioIterative reconstruction algorithmReconstruction algorithmMyocardium wallTorso phantomActivity estimationDetector responseEmission energyBackground compartmentPhantom dataCardiac SPECTActivity distributionRest/stress imagingScatteringCases of patientsOSEMChest painCardiac protocols
2008
Sequential and simultaneous dual‐isotope brain SPECT: Comparison with PET for estimation and discrimination tasks in early Parkinson disease
Trott C, Fakhri G. Sequential and simultaneous dual‐isotope brain SPECT: Comparison with PET for estimation and discrimination tasks in early Parkinson disease. Medical Physics 2008, 35: 3343-3353. PMID: 18697558, PMCID: PMC2673561, DOI: 10.1118/1.2940605.Peer-Reviewed Original ResearchConceptsEnergy resolutionTime-of-flight PET scannerRealistic Monte Carlo simulationsAcquisition energy windowSequential SPECTSystem energy resolutionGamma cameraEnergy windowThree-head cameraPET scannerEmission energyMonte Carlo simulationsDual-isotope SPECTSimultaneous SPECTBrain PETTwo-headed cameraCarlo simulationsProdromal disease stagesIdentical physiological conditionsSpatial resolutionDiscrimination taskStriatal sizeActivity concentrationsEarly identification of PDCamera headIs absolute quantification of dopaminergic neurotransmission studies with 123I SPECT ready for clinical use?
Zaidi H, El Fakhri G. Is absolute quantification of dopaminergic neurotransmission studies with 123I SPECT ready for clinical use? European Journal Of Nuclear Medicine And Molecular Imaging 2008, 35: 1330-1333. PMID: 18523768, PMCID: PMC3124701, DOI: 10.1007/s00259-008-0842-x.Peer-Reviewed Original ResearchMeSH KeywordsBrainCaudate NucleusDopamineDopamine Plasma Membrane Transport ProteinsHumansIodine RadioisotopesLigandsMovement DisordersPutamenRadiopharmaceuticalsSynaptic TransmissionTomography, Emission-Computed, Single-PhotonImproved activity estimation with MC‐JOSEM versus TEW‐JOSEM in SPECT
Ouyang J, Fakhri G, Moore S. Improved activity estimation with MC‐JOSEM versus TEW‐JOSEM in SPECT. Medical Physics 2008, 35: 2029-2040. PMID: 18561679, PMCID: PMC2673642, DOI: 10.1118/1.2907561.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsEquipment DesignImage Processing, Computer-AssistedIndium RadioisotopesLungModels, StatisticalMonte Carlo MethodPhantoms, ImagingRadiotherapy Planning, Computer-AssistedReproducibility of ResultsScattering, RadiationSoftwareTomography, Emission-Computed, Single-PhotonTomography, X-Ray ComputedConceptsMC-JOSEMWater-filled torso phantomMC scatter estimationTriple-energy-windowActivity estimationIterative reconstruction algorithmTorso phantomPhantom studyBackground compartmentScatter estimationActivity distributionAverage relative biasPhantomReconstruction algorithmActivity concentrationsSynthetic projectionsSphere locationScattering
2007
Fast Monte Carlo based joint iterative reconstruction for simultaneous SPECT imaging
Ouyang J, Fakhri G, Moore S. Fast Monte Carlo based joint iterative reconstruction for simultaneous SPECT imaging. Medical Physics 2007, 34: 3263-3272. PMID: 17879789, DOI: 10.1118/1.2756601.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsBrainDopamineHumansImage Processing, Computer-AssistedImaging, Three-DimensionalIodine RadioisotopesMonte Carlo MethodPhotonsRadionuclide ImagingRadiopharmaceuticalsSensitivity and SpecificityTechnetiumTomography, Emission-Computed, Single-PhotonConceptsMC-JOSEMEnergy windowFast Monte CarloSignal-to-noise ratioScatter correction methodOrdered-subsets expectation-maximizationMonte CarloOrdered-subsets expectation-maximization algorithmIterative reconstruction algorithmPrimary photonsReconstruction algorithmPhoton transportSeptal penetrationDetector responseMC simulationsIterative reconstructionAttenuation distributionStandard OSEMPhotonsProjection dataPatient-specific activityDetectorReconstructed imagesScatteringEstimation of scattering
2006
Generalized five‐dimensional dynamic and spectral factor analysis
Fakhri G, Sitek A, Zimmerman R, Ouyang J. Generalized five‐dimensional dynamic and spectral factor analysis. Medical Physics 2006, 33: 1016-1024. PMID: 16696478, DOI: 10.1118/1.2179168.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsAnimalsCorpus StriatumDopamineHaplorhiniHumansImage EnhancementImage Interpretation, Computer-AssistedImaging, Three-DimensionalParkinson DiseaseReproducibility of ResultsSensitivity and SpecificityTomography, Emission-Computed, Single-Photon
2005
Performance of a novel collimator for high‐sensitivity brain SPECT
Fakhri G, Ouyang J, Zimmerman R, Fischman A, Kijewski M. Performance of a novel collimator for high‐sensitivity brain SPECT. Medical Physics 2005, 33: 209-215. PMID: 16485427, DOI: 10.1118/1.2143140.Peer-Reviewed Original ResearchMeSH KeywordsBrainEquipment DesignEquipment Failure AnalysisHumansImage EnhancementPhantoms, ImagingReproducibility of ResultsSensitivity and SpecificityTomography, Emission-Computed, Single-PhotonConceptsSphere activity concentrationNPW-SNRStandard collimatorSphere-to-background activity ratiosAttenuation of countsPhantom centerActivity concentrationsPoint spread functionCentral regionCollimatorPhantom studyStriatal phantomCylindrical backgroundResolution recoveryPhantomSpherical lesionsRamp filterCrystal surfaceSpread functionSignal-to-noise ratioCentral brain structuresFitting imageHealthy volunteersBrain SPECTSphere activity
2004
Quantitative SPECT leads to improved performance in discrimination tasks related to prodromal Alzheimer's disease.
El Fakhri G, Kijewski M, Albert M, Johnson K, Moore S. Quantitative SPECT leads to improved performance in discrimination tasks related to prodromal Alzheimer's disease. Journal Of Nuclear Medicine 2004, 45: 2026-31. PMID: 15585477.Peer-Reviewed Original ResearchMeSH KeywordsAgedAlzheimer DiseaseBrainDementiaHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingTechnetium Tc 99m ExametazimeTomography, Emission-Computed, Single-PhotonConceptsProdromal Alzheimer's diseaseMemory problemsAlzheimer's diseaseDiagnosis of prodromal Alzheimer's diseaseDiagnosis of prodromal ADClinical tasksMRI volume estimationsVariable collimator responseFollow-up periodDementiaGeneral spectral methodConverter groupFollow-upProdromal ADUniform attenuation mapQuestion groupsPairwise discriminant analysisSubjectsQuantitative approachDiscrimination accuracyAnterior cingulate gyrusAttenuation mapNonuniform attenuation mapNormal groupCingulate gyrus
2003
MRI-Guided SPECT Perfusion Measures and Volumetric MRI in Prodromal Alzheimer Disease
El Fakhri G, Kijewski M, Johnson K, Syrkin G, Killiany R, Becker J, Zimmerman R, Albert M. MRI-Guided SPECT Perfusion Measures and Volumetric MRI in Prodromal Alzheimer Disease. JAMA Neurology 2003, 60: 1066-1072. PMID: 12925361, DOI: 10.1001/archneur.60.8.1066.Peer-Reviewed Original ResearchMeSH KeywordsAgedAlzheimer DiseaseBrainHumansMagnetic Resonance ImagingMemory DisordersPredictive Value of TestsRadiographyTechnetium Tc 99m ExametazimeTomography, Emission-Computed, Single-PhotonConceptsRostral anterior cingulateCaudal anterior cingulateMagnetic resonance imagingAnterior cingulateSuperior temporal sulcusPosterior cingulateBasal forebrainTemporal hornEntorhinal cortexTemporal sulcusGroup differencesMemory problemsNondemented patientsFollow-upQuantitative single-photon emissionProdromal phase of Alzheimer's diseaseReceiver operating characteristic curve analysisYears of follow-upAlzheimer's diseasePhase of Alzheimer's diseaseCharacteristic curve analysisVolumetric magnetic resonance imagingMagnetic resonance imaging analysisMagnetic resonance imaging measuresSPECT analysis
2002
Optimization of Ga‐67 imaging for detection and estimation tasks: Dependence of imaging performance on spectral acquisition parameters
Fakhri G, Moore S, Kijewski M. Optimization of Ga‐67 imaging for detection and estimation tasks: Dependence of imaging performance on spectral acquisition parameters. Medical Physics 2002, 29: 1859-1866. PMID: 12201433, DOI: 10.1118/1.1493214.Peer-Reviewed Original ResearchMeSH KeywordsAbdomenAdultAlgorithmsComputer SimulationGallium RadioisotopesHumansMaleModels, BiologicalMonte Carlo MethodQuality ControlRadiopharmaceuticalsReproducibility of ResultsSensitivity and SpecificityStochastic ProcessesThoraxTomography, Emission-Computed, Single-PhotonConceptsIdeal signal-to-noise ratioEnergy windowSignal-to-noise ratioMonte Carlo programDetection of spheresTorso phantomPhantom acquisitionsSphere of radiusEstimation taskPhantom dataLower-energyGa-67 imagingPhantomAcquisition parametersActivity concentrationsSpectral acquisition parametersGa-67Sphere sizeEnergyPhotopeakTumor imagingOptimal windowTaskClinicMonte
2001
Absolute activity quantitation in simultaneous 123I/99mTc brain SPECT.
El Fakhri G, Moore S, Maksud P, Aurengo A, Kijewski M. Absolute activity quantitation in simultaneous 123I/99mTc brain SPECT. Journal Of Nuclear Medicine 2001, 42: 300-8. PMID: 11216530.Peer-Reviewed Original ResearchMeSH KeywordsAlzheimer DiseaseBenzamidesBrainCerebellumCerebral CortexCerebrovascular CirculationCorpus CallosumHumansIodine RadioisotopesMonte Carlo MethodNeural Networks, ComputerParkinson DiseasePhantoms, ImagingPutamenPyrrolidinesRadiopharmaceuticalsSensitivity and SpecificityTechnetium Tc 99m ExametazimeTomography, Emission-Computed, Single-PhotonConceptsOrdered-subset expectation maximizationDistance-dependent collimator responseActivity quantitationActivity distributionIterative ordered-subsets expectation maximizationZubal brain phantomAsymmetric windowsSimulated normal populationPathological studiesDecay photonsBrain SPECTCollimator responseNonuniform attenuationDual-isotope imagingBrain phantomMonte Carlo simulationsCorpus callosumNormal populationPartial volume effectsCarlo simulationsCortical lobesAssessment of brain perfusionScatteringCross-talkBrain perfusion
2000
Relative impact of scatter, collimator response, attenuation, and finite spatial resolution corrections in cardiac SPECT.
El Fakhri G, Buvat I, Benali H, Todd-Pokropek A, Di Paola R. Relative impact of scatter, collimator response, attenuation, and finite spatial resolution corrections in cardiac SPECT. Journal Of Nuclear Medicine 2000, 41: 1400-8. PMID: 10945534.Peer-Reviewed Original ResearchMeSH KeywordsHeartHumansImage Processing, Computer-AssistedLiverPhantoms, ImagingRadiopharmaceuticalsReproducibility of ResultsScattering, RadiationTissue DistributionTomography, Emission-Computed, Single-PhotonConceptsDepth-dependent collimator responseSpatial resolution correctionCollimator responseFinite spatial resolutionBull's-eye mapCardiac SPECTActivity quantitationAttenuation correctionScatter correctionResolution correctionSpatial resolutionCollimator response correctionsSignal-to-noise ratioFrequency-distance principleImpact of scatteringLeft ventricleMonte Carlo simulationsCardiac phantomScatteringCarlo simulationsLV cavityAbsolute quantitationImproved contrastLV regionsProcessing schemeShould scatter be corrected in both transmission and emission data for accurate quantitation in cardiac SPET?
El Fakhri G, Buvat I, Almeida P, Bendriem B, Todd-Pokropek A, Benali H. Should scatter be corrected in both transmission and emission data for accurate quantitation in cardiac SPET? European Journal Of Nuclear Medicine And Molecular Imaging 2000, 27: 1356-1364. PMID: 11007518, DOI: 10.1007/s002590000304.Peer-Reviewed Original ResearchConceptsTransmission dataSingle-photon emission tomographyActivity distributionSignal-to-noise ratioCardiac single-photon emission tomographyAttenuation-corrected imagesAmount of scatterNarrow transmission windowHot compartmentActivity quantitationTransmission scanEmission dataEmission acquisitionTransmission windowReduced signal-to-noise ratioTransmission scatteringScatteringScattering componentPhantomQuantitative accuracyReduced scatteringAttenuating mediaReconstructed imagesLine sourceEmission