2021
Total-body dynamic PET/CT of micro-metastatic lymph node in a patient with lung cancer
Fu F, Li X, Wu Y, Xu J, Bai Y, Gao Y, Wang Z, Zhang W, Wei W, El Fakhri G, Shao F, Wang M. Total-body dynamic PET/CT of micro-metastatic lymph node in a patient with lung cancer. European Journal Of Nuclear Medicine And Molecular Imaging 2021, 48: 1678-1679. PMID: 33392715, DOI: 10.1007/s00259-020-05121-1.Peer-Reviewed Original ResearchFluorodeoxyglucose F18HumansLung NeoplasmsLymph NodesPositron Emission Tomography Computed TomographySensitivity and Specificity
2016
Pharmacokinetic Evaluation of the Tau PET Radiotracer 18F-T807 (18F-AV-1451) in Human Subjects
Wooten D, Guehl N, Verwer E, Shoup T, Yokell D, Zubcevik N, Vasdev N, Zafonte R, Johnson K, Fakhri G, Normandin M. Pharmacokinetic Evaluation of the Tau PET Radiotracer 18F-T807 (18F-AV-1451) in Human Subjects. Journal Of Nuclear Medicine 2016, 58: 484-491. PMID: 27660144, PMCID: PMC5334185, DOI: 10.2967/jnumed.115.170910.Peer-Reviewed Original ResearchConceptsDistribution volume ratioTraumatic brain injuryMetabolite-corrected arterial input functionPET imagingPlasma radioactivity concentrationsTemporal cortexDynamic PET imagesTotal volume of distributionVolume of distributionTraumatic brain injury subjectsMesial temporal cortexArterial blood samplesPosterior cingulate gyrusFocal uptakeSUV ratioHuman subjectsArterial input functionPosterior corpus callosumBolus injectionPharmacokinetic evaluation
2014
Towards coronary plaque imaging using simultaneous PET-MR: a simulation study
Petibon Y, Fakhri G, Nezafat R, Johnson N, Brady T, Ouyang J. Towards coronary plaque imaging using simultaneous PET-MR: a simulation study. Physics In Medicine And Biology 2014, 59: 1203-1222. PMID: 24556608, PMCID: PMC4061607, DOI: 10.1088/0031-9155/59/5/1203.Peer-Reviewed Original ResearchMeSH KeywordsComputer SimulationCoronary AngiographyCoronary StenosisHumansImage Interpretation, Computer-AssistedImaging, Three-DimensionalMagnetic Resonance AngiographyModels, CardiovascularMultimodal ImagingPhantoms, ImagingPositron-Emission TomographyReproducibility of ResultsSensitivity and SpecificityConceptsSimultaneous PET-MRChannelized Hotelling observerAttenuation mapMotion correctionPET-MRFluorodeoxyglucose-positron emission tomography imagingRespiratory motion fieldsMotion correction methodCho SNRMotion correction techniqueAnthropomorphic phantomUncorrected reconstructionsRespiratory motionXCAT phantomCoronary plaque imagingMonte Carlo simulationsPET reconstructionXCATActivity distributionCardiac gatingNon-rigid registrationHotelling observerCarlo simulationsPlaque imagingPhantom
2013
Matched Signal Detection on Graphs: Theory and Application to Brain Network Classification
Hu C, Cheng L, Sepulcre J, El Fakhri G, Lu Y, Li Q. Matched Signal Detection on Graphs: Theory and Application to Brain Network Classification. Lecture Notes In Computer Science 2013, 23: 1-12. PMID: 24683953, DOI: 10.1007/978-3-642-38868-2_1.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsAlzheimer DiseaseAniline CompoundsBenzothiazolesBrainBrain MappingConnectomeHumansImage EnhancementImage Interpretation, Computer-AssistedNerve NetNeural PathwaysPattern Recognition, AutomatedPositron-Emission TomographyReproducibility of ResultsSensitivity and SpecificityThiazolesTissue DistributionConceptsBrain network classificationNetwork classification problemWeighted energy detectorPrinciple component analysisSub-manifold structureTraditional principle component analysisSubspace detectionTraining dataEnergy detectorGraph structureProblem of Alzheimer's diseaseGraph LaplacianNetwork classificationNoise varianceLevel of smoothnessWeighted graphSignal detectionIntrinsic structureSignal modelGraphSubspaceIsing modelNoiseSignal variationsComponent analysis
2010
Novel Scatter Compensation of List-Mode PET Data Using Spatial and Energy Dependent Corrections
Guérin B, Fakhri G. Novel Scatter Compensation of List-Mode PET Data Using Spatial and Energy Dependent Corrections. IEEE Transactions On Medical Imaging 2010, 30: 759-773. PMID: 21118770, PMCID: PMC3120772, DOI: 10.1109/tmi.2010.2095025.Peer-Reviewed Original Research
2009
Quantitative simultaneous cardiac SPECT using MC‐JOSEM
Ouyang J, Zhu X, Trott C, Fakhri G. Quantitative simultaneous cardiac SPECT using MC‐JOSEM. Medical Physics 2009, 36: 602-611. PMID: 19292000, PMCID: PMC2673670, DOI: 10.1118/1.3063544.Peer-Reviewed Original ResearchConceptsMC-JOSEMEnergy windowWater-filled torso phantomScatter correctionPhotopeak energy windowStandard OSEMCardiac SPECT imagingActivity concentration ratioIterative reconstruction algorithmReconstruction algorithmMyocardium wallTorso phantomActivity estimationDetector responseEmission energyBackground compartmentPhantom dataCardiac SPECTActivity distributionRest/stress imagingScatteringCases of patientsOSEMChest painCardiac protocols
2007
Fast Monte Carlo based joint iterative reconstruction for simultaneous SPECT imaging
Ouyang J, Fakhri G, Moore S. Fast Monte Carlo based joint iterative reconstruction for simultaneous SPECT imaging. Medical Physics 2007, 34: 3263-3272. PMID: 17879789, DOI: 10.1118/1.2756601.Peer-Reviewed Original ResearchConceptsMC-JOSEMEnergy windowFast Monte CarloSignal-to-noise ratioScatter correction methodOrdered-subsets expectation-maximizationMonte CarloOrdered-subsets expectation-maximization algorithmIterative reconstruction algorithmPrimary photonsReconstruction algorithmPhoton transportSeptal penetrationDetector responseMC simulationsIterative reconstructionAttenuation distributionStandard OSEMPhotonsProjection dataPatient-specific activityDetectorReconstructed imagesScatteringEstimation of scattering
2006
Generalized five‐dimensional dynamic and spectral factor analysis
Fakhri G, Sitek A, Zimmerman R, Ouyang J. Generalized five‐dimensional dynamic and spectral factor analysis. Medical Physics 2006, 33: 1016-1024. PMID: 16696478, DOI: 10.1118/1.2179168.Peer-Reviewed Original Research
2005
Performance of a novel collimator for high‐sensitivity brain SPECT
Fakhri G, Ouyang J, Zimmerman R, Fischman A, Kijewski M. Performance of a novel collimator for high‐sensitivity brain SPECT. Medical Physics 2005, 33: 209-215. PMID: 16485427, DOI: 10.1118/1.2143140.Peer-Reviewed Original ResearchMeSH KeywordsBrainEquipment DesignEquipment Failure AnalysisHumansImage EnhancementPhantoms, ImagingReproducibility of ResultsSensitivity and SpecificityTomography, Emission-Computed, Single-PhotonConceptsSphere activity concentrationNPW-SNRStandard collimatorSphere-to-background activity ratiosAttenuation of countsPhantom centerActivity concentrationsPoint spread functionCentral regionCollimatorPhantom studyStriatal phantomCylindrical backgroundResolution recoveryPhantomSpherical lesionsRamp filterCrystal surfaceSpread functionSignal-to-noise ratioCentral brain structuresFitting imageHealthy volunteersBrain SPECTSphere activityCollimator Optimization for Detection and Quantitation Tasks: Application to Gallium-67 Imaging
Moore S, Kijewski M, Fakhri G. Collimator Optimization for Detection and Quantitation Tasks: Application to Gallium-67 Imaging. IEEE Transactions On Medical Imaging 2005, 24: 1347-1356. PMID: 16229420, DOI: 10.1109/tmi.2005.857211.Peer-Reviewed Original ResearchCitratesComputer SimulationComputer-Aided DesignEquipment DesignEquipment Failure AnalysisGalliumHumansImage EnhancementImage Interpretation, Computer-AssistedModels, BiologicalNeoplasmsPhantoms, ImagingPositron-Emission TomographyRadiopharmaceuticalsReproducibility of ResultsSensitivity and SpecificityQuantitative dynamic cardiac 82Rb PET using generalized factor and compartment analyses.
El Fakhri G, Sitek A, Guérin B, Kijewski M, Di Carli M, Moore S. Quantitative dynamic cardiac 82Rb PET using generalized factor and compartment analyses. Journal Of Nuclear Medicine 2005, 46: 1264-71. PMID: 16085581.Peer-Reviewed Original ResearchAdultAgedAged, 80 and overAlgorithmsComputer SimulationCoronary Artery DiseaseFeasibility StudiesFemaleHeartHumansImage Interpretation, Computer-AssistedMaleMiddle AgedModels, CardiovascularPositron-Emission TomographyRadiopharmaceuticalsReproducibility of ResultsRubidium RadioisotopesSensitivity and SpecificitySeverity of Illness Index
2001
Absolute activity quantitation in simultaneous 123I/99mTc brain SPECT.
El Fakhri G, Moore S, Maksud P, Aurengo A, Kijewski M. Absolute activity quantitation in simultaneous 123I/99mTc brain SPECT. Journal Of Nuclear Medicine 2001, 42: 300-8. PMID: 11216530.Peer-Reviewed Original ResearchAlzheimer DiseaseBenzamidesBrainCerebellumCerebral CortexCerebrovascular CirculationCorpus CallosumHumansIodine RadioisotopesMonte Carlo MethodNeural Networks, ComputerParkinson DiseasePhantoms, ImagingPutamenPyrrolidinesRadiopharmaceuticalsSensitivity and SpecificityTechnetium Tc 99m ExametazimeTomography, Emission-Computed, Single-Photon