2009
Reproducibility and Accuracy of Quantitative Myocardial Blood Flow Assessment with 82Rb PET: Comparison with 13N-Ammonia PET
Fakhri G, Kardan A, Sitek A, Dorbala S, Abi-Hatem N, Lahoud Y, Fischman A, Coughlan M, Yasuda T, Di Carli M. Reproducibility and Accuracy of Quantitative Myocardial Blood Flow Assessment with 82Rb PET: Comparison with 13N-Ammonia PET. Journal Of Nuclear Medicine 2009, 50: 1062-1071. PMID: 19525467, PMCID: PMC3133618, DOI: 10.2967/jnumed.104.007831.Peer-Reviewed Original ResearchConceptsCoronary flow reserveMyocardial blood flowQuantitation of myocardial blood flowTime-activity curvesInterobserver reliabilityBaseline myocardial blood flowBlood poolPET studiesAssessment of myocardial perfusionTissue time-activity curvesEstimation of myocardial blood flowMyocardial blood flow quantitationBland-Altman plotsBlood flow assessmentRight ventricular blood poolCompartment analysisMyocardial blood flow assessmentPeak stressVentricular blood poolReproducibility of myocardial blood flowDynamic restCardiac PETEstimation of coronary flow reserveIntraobserver variabilityMyocardial perfusionQuantitative relationship between coronary calcium content and coronary flow reserve as assessed by integrated PET/CT imaging
Curillova Z, Yaman B, Dorbala S, Kwong R, Sitek A, El Fakhri G, Anagnostopoulos C, Di Carli M. Quantitative relationship between coronary calcium content and coronary flow reserve as assessed by integrated PET/CT imaging. European Journal Of Nuclear Medicine And Molecular Imaging 2009, 36: 1603-1610. PMID: 19387640, PMCID: PMC3117296, DOI: 10.1007/s00259-009-1121-1.Peer-Reviewed Original ResearchConceptsCoronary artery calcium scoreCoronary artery calciumCoronary vasodilator functionCoronary flow reserveCoronary artery diseaseHyperemic myocardial blood flowMyocardial blood flowVasodilator functionWeak inverse correlationCAC scoreCoronary artery calcium contentFlow reserveIncreasing CAC scorePer-vessel basisPer-patient basisInverse correlationBody mass indexCoronary calcium contentCoronary risk factorsCoronary vascular resistancePET/CT imagingConclusionIn patientsArtery calciumVascular resistanceMass index
2008
Quantitative relationship between coronary vasodilator reserve assessed by 82Rb PET imaging and coronary artery stenosis severity
Anagnostopoulos C, Almonacid A, El Fakhri G, Curillova Z, Sitek A, Roughton M, Dorbala S, Popma J, Di Carli M. Quantitative relationship between coronary vasodilator reserve assessed by 82Rb PET imaging and coronary artery stenosis severity. European Journal Of Nuclear Medicine And Molecular Imaging 2008, 35: 1593-1601. PMID: 18425513, PMCID: PMC3124702, DOI: 10.1007/s00259-008-0793-2.Peer-Reviewed Original ResearchConceptsPositron emission tomographyCoronary artery diseaseCoronary vasodilator reserveMyocardial blood flowPositron emission tomography imagingPercent diameter stenosisDiameter stenosisEmission tomographyAge-matchedStenosis severityHyperaemic myocardial blood flowRisk factorsStress myocardial blood flowVasodilator reserveFunctional assessment of coronary artery diseaseAssessment of coronary artery diseaseClinically useful tool
2005
Quantitative dynamic cardiac 82Rb PET using generalized factor and compartment analyses.
El Fakhri G, Sitek A, Guérin B, Kijewski M, Di Carli M, Moore S. Quantitative dynamic cardiac 82Rb PET using generalized factor and compartment analyses. Journal Of Nuclear Medicine 2005, 46: 1264-71. PMID: 16085581.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAlgorithmsComputer SimulationCoronary Artery DiseaseFeasibility StudiesFemaleHeartHumansImage Interpretation, Computer-AssistedMaleMiddle AgedModels, CardiovascularPositron-Emission TomographyRadiopharmaceuticalsReproducibility of ResultsRubidium RadioisotopesSensitivity and SpecificitySeverity of Illness IndexConceptsMyocardial perfusionAbsolute myocardial perfusionCatheterization resultsMyocardial tissue extractsDipyridamole stressCardiac PETClinical valueMyocardial factorsFactor analysis of dynamic sequencesPatient studiesLVNoninvasive estimationAccurate input functionPatientsCompartment analysisAverage errorPerfusionParametric mappingTissue extractsRV contributionRV