2020
Penalized Parametric PET Image Estimation Using Local Linear Fitting
Kim K, Gong K, Moon S, Fakhri G, Normandin M, Li Q. Penalized Parametric PET Image Estimation Using Local Linear Fitting. IEEE Transactions On Radiation And Plasma Medical Sciences 2020, 4: 750-758. DOI: 10.1109/trpms.2020.3024123.Peer-Reviewed Original ResearchReconstructed framesImage estimationGraphical modelsFull-dose imagesStatic imagesParametric imaging methodFunction extractionPhysiological informationImagesPositron emission tomographyLogan graphical modelConventional methodsPatient studiesKinetic parametersSuboptimalityFrameDynamic imagingTwo-tissue compartment model
2019
Evaluation of pharmacokinetic modeling strategies for in-vivo quantification of tau with the radiotracer [18F]MK6240 in human subjects
Guehl N, Wooten D, Yokell D, Moon S, Dhaynaut M, Katz S, Moody K, Gharagouzloo C, Kas A, Johnson K, El Fakhri G, Normandin M. Evaluation of pharmacokinetic modeling strategies for in-vivo quantification of tau with the radiotracer [18F]MK6240 in human subjects. European Journal Of Nuclear Medicine And Molecular Imaging 2019, 46: 2099-2111. PMID: 31332496, PMCID: PMC6709592, DOI: 10.1007/s00259-019-04419-z.Peer-Reviewed Original ResearchConceptsReference tissue methodDistribution volume ratioTissue methodIn vivo quantificationPharmacokinetic modeling strategiesArterial plasma input functionMultilinear reference tissue methodsTwo-tissue compartment modelBlood:plasma ratioTissue-to-plasmaPlasma input functionPlasma concentration time courseBlood-based methodMethodsThirty-five subjectsSUV ratioBlood-based analysesData setsArterial input functionPET scansControl subjectsMild cognitive impairmentPlasma ratioRadiometabolite analysisHealthy controlsConcentration time course