2018
A novel depth-of-interaction rebinning strategy for ultrahigh resolution PET
Kim K, Dutta J, Groll A, Fakhri G, Meng L, Li Q. A novel depth-of-interaction rebinning strategy for ultrahigh resolution PET. Physics In Medicine And Biology 2018, 63: 165011. PMID: 30040073, PMCID: PMC6375090, DOI: 10.1088/1361-6560/aad58c.Peer-Reviewed Original ResearchConceptsDepth of interactionReconstructed imagesAlternating direction methodReconstructed image qualityPoisson log-likelihoodImage qualitySub-sampling methodPositron emission tomography systemReduce noise effectsDOI layersReconstruction frameworkDetector pixel sizePoint source experimentsQuadratic surrogatesCdZnTe detectorsAnimal positron emission tomographyLog-likelihoodDirection methodSmall animal positron emission tomographySource ExperimentPhoton countingRebinning methodSystem matrixNoise effectsSinogram
2017
Joint estimation of activity image and attenuation sinogram using time-of-flight positron emission tomography data consistency condition filtering
Li Q, Li H, Kim K, Fakhri G. Joint estimation of activity image and attenuation sinogram using time-of-flight positron emission tomography data consistency condition filtering. Journal Of Medical Imaging 2017, 4: 023502-023502. PMID: 28466027, PMCID: PMC5405780, DOI: 10.1117/1.jmi.4.2.023502.Peer-Reviewed Original ResearchData consistency conditionsMaximum likelihood attenuation correction factorsAttenuation sinogramConsistency conditionsJoint estimationJoint log-likelihood functionPET emission dataAttenuation correction factorsTime-of-flight (TOFActive imagingJoint estimation methodLog-likelihood functionPoisson noiseReconstruction resultsAttenuation correctionSinogram filteringPrevent convergenceEmission dataSinogramPositron emission tomography dataEstimation methodComputer simulationsPositron emission tomographyIterative methodCorrection factorDirect parametric reconstruction in dynamic PET myocardial perfusion imaging: in vivo studies
Petibon Y, Rakvongthai Y, Fakhri G, Ouyang J. Direct parametric reconstruction in dynamic PET myocardial perfusion imaging: in vivo studies. Physics In Medicine And Biology 2017, 62: 3539-3565. PMID: 28379843, PMCID: PMC5739089, DOI: 10.1088/1361-6560/aa6394.Peer-Reviewed Original ResearchConceptsPET sinogramsSignal-to-noise ratioList-mode PET dataSiemens Biograph mMR scannerList-mode dataMyocardial perfusion imagingNoise realizationsPET myocardial perfusion imagingLow count levelsLeast-squares fitBiograph mMR scannerPET projection dataOriginal list-mode dataMyocardial blood flowCount levelsParametric reconstructionOSEMReconstruction methodIndependent noise realizationsNormal count levelsSinogramDirect reconstructionDynamic sinogramsKinetic modelPoor signal-to-noise ratio
2014
Spectral CT Using Multiple Balanced K-Edge Filters
Rakvongthai Y, Worstell W, Fakhri G, Bian J, Lorsakul A, Ouyang J. Spectral CT Using Multiple Balanced K-Edge Filters. IEEE Transactions On Medical Imaging 2014, 34: 740-747. PMID: 25252276, PMCID: PMC4349342, DOI: 10.1109/tmi.2014.2358561.Peer-Reviewed Original ResearchConceptsK-edge filtersReconstructed attenuation coefficientsEnergy binsAttenuation coefficientMultiple energy binsX-ray sourcesX-ray tubeBack-projection reconstructionSpectral CT imagingTransmission matrixModel expectationsSinogram binsBeam hardeningComplex phantomsSpectral computed tomographyK-edgeAttenuation imagesSpectral CTCT scannerX-rayConventional detectorsBack-projectionSinogramPhantomCost-effective system design
2013
Direct reconstruction of cardiac PET kinetic parametric images using a preconditioned conjugate gradient approach
Rakvongthai Y, Ouyang J, Guerin B, Li Q, Alpert N, Fakhri G. Direct reconstruction of cardiac PET kinetic parametric images using a preconditioned conjugate gradient approach. Medical Physics 2013, 40: 102501. PMID: 24089922, PMCID: PMC3779266, DOI: 10.1118/1.4819821.Peer-Reviewed Original Research
2010
MRI-Assisted PET Motion Correction for Neurologic Studies in an Integrated MR-PET Scanner
Catana C, Benner T, van der Kouwe A, Byars L, Hamm M, Chonde D, Michel C, Fakhri G, Schmand M, Sorensen A. MRI-Assisted PET Motion Correction for Neurologic Studies in an Integrated MR-PET Scanner. Journal Of Nuclear Medicine 2010, 52: 154-161. PMID: 21189415, PMCID: PMC3125596, DOI: 10.2967/jnumed.110.079343.Peer-Reviewed Original ResearchConceptsLines of responseMotion correctionPET motion correctionRigid-body motion correctionMC algorithmPET volumesQuantitative accuracyMR-PET scannersPET image qualityScatter sinogramEcho-planar imagingHoffman phantomSinogram spaceList-modeRandom coincidencesMotion tracking techniquePrototype scannerPhantom volumeImage qualityMR-PETMC methodPET dataSinogramPhantomVolunteer studies
2007
Impact of Acquisition Geometry, Image Processing, and Patient Size on Lesion Detection in Whole-Body 18F-FDG PET
Fakhri G, Santos P, Badawi R, Holdsworth C, Van Den Abbeele A, Kijewski M. Impact of Acquisition Geometry, Image Processing, and Patient Size on Lesion Detection in Whole-Body 18F-FDG PET. Journal Of Nuclear Medicine 2007, 48: 1951-1960. PMID: 18006613, DOI: 10.2967/jnumed.108.007369.Peer-Reviewed Original ResearchConceptsAttenuation-weighted OSEMOrdered-subset expectation maximizationNoise equivalent countPhantom sizeBed positionCho SNRPatient sizeFourier rebinningAttenuation mapPET scannerLesion detectionMarginal detectionTransmission scanWhole-body (18)F-FDG PETAttenuation correctionWhole-body 18F-FDG PETHotelling observerScaling 2DSinogramReconstructed volumeDetection SNRPhantomSystematic improvementFBPScattering
2003
A Multi-Scanner Evaluation of PET Image Quality Using Phantom Studies
Surti S, Badawi R, Holdsworth C, Fakhri G, Kinahan P, Karp J. A Multi-Scanner Evaluation of PET Image Quality Using Phantom Studies. 2003, 4: 2425-2427. DOI: 10.1109/nssmic.2003.1352384.Peer-Reviewed Original ResearchSignal-to-noise ratioImage signal-to-noisePET image qualityImage signal-to-noise ratioDiameter phantomImage qualityPhantom diameterPET scannerNEC ratesPhantom studyMeasures of image qualitySignal-to-noisePhantomAcquisition modeFilter observerSpecific tasksAccurate measurementRate dropsSinogramScannerPreliminary resultsECAT