2017
A report of the automated radiosynthesis of the tau positron emission tomography radiopharmaceutical, [18F]‐THK‐5351
Neelamegam R, Yokell D, Rice P, Furumoto S, Kudo Y, Okamura N, Fakhri G. A report of the automated radiosynthesis of the tau positron emission tomography radiopharmaceutical, [18F]‐THK‐5351. Journal Of Labelled Compounds And Radiopharmaceuticals 2017, 60: 140-146. PMID: 27859483, DOI: 10.1002/jlcr.3482.Peer-Reviewed Original ResearchConceptsO-THPNucleophilic fluorination reactionsHydrochloric acidFluorination reactionDilute hydrochloric acidSemi-preparative high-performance liquid chromatographyTosylate precursorHigh-performance liquid chromatographyUncorrected radiochemical yieldDimethyl sulfoxideRadiochemical yieldRadiosynthesis moduleMulti-center trialLiquid chromatographyAutomated radiosynthesisRadiosynthesisPositron emission tomography radiopharmaceuticalsPET imaging agentUnited States Pharmacopeia
2013
Dual-Tracer PET Using Generalized Factor Analysis of Dynamic Sequences
El Fakhri G, Trott C, Sitek A, Bonab A, Alpert N. Dual-Tracer PET Using Generalized Factor Analysis of Dynamic Sequences. Molecular Imaging And Biology 2013, 15: 666-674. PMID: 23636489, PMCID: PMC3812387, DOI: 10.1007/s11307-013-0631-1.Peer-Reviewed Original ResearchConceptsEmit gamma raysPositron emission tomographyNear-simultaneous imagingSingle-photon emissionBrain PET studiesGamma raysSingle-photon emission computed tomographyActivity distributionRaclopride studiesEmission computed tomographyPositron emission tomography radiopharmaceuticalsSimultaneous imagingD2 bindingFactor analysis of dynamic sequencesActivity estimationTime activity curvesRacloprideFDGRhesus monkeysEmission tomographyPET studiesActivation curveBrain metabolismEmissionSimulate human data