Impact of multisession 40Hz tACS on hippocampal perfusion in patients with Alzheimer’s disease
Sprugnoli G, Munsch F, Cappon D, Paciorek R, Macone J, Connor A, El Fakhri G, Salvador R, Ruffini G, Donohoe K, Shafi M, Press D, Alsop D, Pascual Leone A, Santarnecchi E. Impact of multisession 40Hz tACS on hippocampal perfusion in patients with Alzheimer’s disease. Alzheimer's Research & Therapy 2021, 13: 203. PMID: 34930421, PMCID: PMC8690894, DOI: 10.1186/s13195-021-00922-4.Peer-Reviewed Original ResearchConceptsTemporal lobeMethodsIn two open-label studiesMild to moderate AD participantsPreclinical models of ADGamma bandBrain oscillatory activityModerate AD participantsBilateral temporal lobesEpisodic memoryAdministered 1 hSpectral power changesBrain areasModulates cerebral perfusionAD participantsPlacebo-controlled trialHippocampal perfusionModel of ADOpen-label studyNeural activityAssociated with alterationsNon-invasive countermeasureCognitive AssessmentCognitive impairmentCognitive protectionOscillatory activityGamma‐induction in frontotemporal dementia (GIFTeD) randomized placebo‐controlled trial: Rationale, noninvasive brain stimulation protocol, and study design
Assogna M, Sprugnoli G, Press D, Dickerson B, Macone J, Bonnì S, Borghi I, Connor A, Hoffman M, Grover N, Wong B, Shen C, Martorana A, O'Reilly M, Ruffini G, Fakhri G, Koch G, Santarnecchi E. Gamma‐induction in frontotemporal dementia (GIFTeD) randomized placebo‐controlled trial: Rationale, noninvasive brain stimulation protocol, and study design. Alzheimer's & Dementia: Translational Research & Clinical Interventions 2021, 7: e12219. PMID: 35141396, PMCID: PMC8813035, DOI: 10.1002/trc2.12219.Peer-Reviewed Original ResearchBehavioral variant FTDFrontotemporal dementiaPlacebo-controlled trialDiagnosis of behavioural variant frontotemporal dementiaBehavioral variant frontotemporal dementiaNoninvasive brain stimulation protocolsStructural magnetic resonance imagingBehavioural variant FTD patientsGamma oscillatory activityOscillatory brain activityMagnetic resonance imagingMouse model of frontotemporal dementiaBrain oscillatory patternsNon-invasive brain stimulationBrain glucose hypometabolismInstitutional review boardBrain stimulation protocolsBehavioral alterationsFrequency-specific mannerBrain activityBehavioral assessmentFluorodeoxyglucose (FDG)-positron emission tomographyCognitive functionRandomized placebo-controlled trialNeural activity