Stochastic simulation of radium-223 dichloride therapy at the sub-cellular level
Gholami Y, Zhu X, Fulton R, Meikle S, El-Fakhri G, Kuncic Z. Stochastic simulation of radium-223 dichloride therapy at the sub-cellular level. Physics In Medicine And Biology 2015, 60: 6087-6096. PMID: 26216391, DOI: 10.1088/0031-9155/60/15/6087.Peer-Reviewed Original ResearchConceptsEstimate radiation damageAlpha particle tracksAlpha-particle emittersMonte Carlo modelIonization clustersDose depositionAlpha particlesAlpha emissionParticle therapyAlpha-particle therapyEnergy depositionRadiation damageCarlo modelEfficacy of cell killingParticle emittersRadium-223 dichlorideBone-seeking radionuclidesParticle trackingRadium-223Prostate cancerAverage doseCell nucleiCell killingIndirect DNA damageNucleus