2024
Advances and Insights in Positron Emission Tomography Tracers for Metabotropic Glutamate Receptor 4 Imaging
Wang J, Li Y, Fakhri G. Advances and Insights in Positron Emission Tomography Tracers for Metabotropic Glutamate Receptor 4 Imaging. Journal Of Medicinal Chemistry 2024, 67: 10517-10529. PMID: 38924702, PMCID: PMC11290609, DOI: 10.1021/acs.jmedchem.3c02431.Peer-Reviewed Original ResearchConceptsPositive allosteric modulatorsPositron emission tomographyPositron emission tomography radioligandsAllosteric modulatorsMGluR4 positive allosteric modulatorsMetabotropic glutamate receptor subtype 4PET ligandNeurological disordersPositron emission tomography tracersEmission tomographySubtype 4Molecular imaging modalitiesEffective treatmentMetabotropicDisordersParent drugImaging modalitiesPET tracersMGluR4Therapeutic targetPositron emitting radioisotopesSelection of lead compoundsLiving subjectsPositronQuantitative accuracy
2018
Magnetic resonance imaging based anatomical assessment of tongue impairment due to amyotrophic lateral sclerosis: A preliminary study
Lee E, Xing F, Ahn S, Reese T, Wang R, Green J, Atassi N, Wedeen V, El Fakhri G, Woo J. Magnetic resonance imaging based anatomical assessment of tongue impairment due to amyotrophic lateral sclerosis: A preliminary study. The Journal Of The Acoustical Society Of America 2018, 143: el248-el254. PMID: 29716267, PMCID: PMC5895467, DOI: 10.1121/1.5030134.Peer-Reviewed Original ResearchConceptsDiffusion tensor imagingHigh-resolution magnetic resonance imagingMagnetic resonance imagingResonance imagingEffects of amyotrophic lateral sclerosisAmyotrophic lateral sclerosisTensor imagingAmyotrophic lateral sclerosis patientsFiber connectionsSpeechNeurological disordersLateral sclerosis
2017
Subject-specific anatomical assessment of the human tongue in amyotrophic lateral sclerosis (ALS) by high-resolution MRI and diffusion tensor imaging
Lee E, Xing F, Ahn S, Reese T, Wang R, Green J, Atassi N, Wedeen V, Fakhri G, Woo J. Subject-specific anatomical assessment of the human tongue in amyotrophic lateral sclerosis (ALS) by high-resolution MRI and diffusion tensor imaging. The Journal Of The Acoustical Society Of America 2017, 142: 2639-2639. DOI: 10.1121/1.5014672.Peer-Reviewed Original ResearchHigh-resolution MRIDiffusion tensor imagingAmyotrophic lateral sclerosis subjectsAmyotrophic lateral sclerosisTensor imagingAmyotrophic lateral sclerosis patientsLateral sclerosisAnatomical assessmentSuperior longitudinal muscleNon-invasive imagingDeformable registrationMotor neuronsLongitudinal muscleFractional anisotropyMuscle fibersIrreversible neurological disorderB0 imagesNeurological disordersHuman tongueMRIMotor cortexTongueSclerosisMuscleAnatomical differences