2020
Colorimetric biosensing of glucose in human serum based on the intrinsic oxidase activity of hollow MnO 2 nanoparticles
Chen L, Gao H, Bai Y, Wei W, Wang J, El Fakhri G, Wang M. Colorimetric biosensing of glucose in human serum based on the intrinsic oxidase activity of hollow MnO 2 nanoparticles. New Journal Of Chemistry 2020, 44: 15066-15070. DOI: 10.1039/d0nj02387f.Peer-Reviewed Original ResearchBiosensing of glucoseDetection of glucoseHuman serum samplesOxidase-like activityAnalysis of human serum samplesMnO 2 nanoparticlesGlucose oxidaseAbundant nanosheetsExcellent selectivityManganese dioxide nanoparticlesCatalytic propertiesAcidic mediumHuman serumColorimetric biosensingLinear responseColor reagentRoutine analysisColorimetric signalOxidize glucoseNanoparticlesConcentrations of glucoseSerum samplesChemical compoundsOxidase activityLow costA Chelate-Free Nano-Platform for Incorporation of Diagnostic and Therapeutic Isotopes
Gholami Y, Josephson L, Akam E, Caravan P, Wilks M, Pan X, Maschmeyer R, Kolnick A, Fakhri G, Normandin M, Kuncic Z, Yuan H. A Chelate-Free Nano-Platform for Incorporation of Diagnostic and Therapeutic Isotopes. International Journal Of Nanomedicine 2020, 15: 31-47. PMID: 32021163, PMCID: PMC6954846, DOI: 10.2147/ijn.s227931.Peer-Reviewed Original ResearchConceptsDynamic light scatteringRadiochemical yieldSize exclusion chromatographyThin-layer chromatographyEmpty d orbitalsF-orbital electronsD-orbitalsICP-MSRelaxation spectrometryRadioactive isotopologuesMass spectrometryInductively coupled plasma mass spectrometryChelate-freeNonradioactive metalsPositive chargePlasma mass spectrometryFh NPsNanoparticlesReaction timeLight scatteringMetalExclusion chromatographySpectrometryApproved drugsReaction
2017
Heat-induced-radiolabeling and click chemistry: A powerful combination for generating multifunctional nanomaterials
Yuan H, Wilks M, Fakhri G, Normandin M, Kaittanis C, Josephson L. Heat-induced-radiolabeling and click chemistry: A powerful combination for generating multifunctional nanomaterials. PLOS ONE 2017, 12: e0172722. PMID: 28225818, PMCID: PMC5321420, DOI: 10.1371/journal.pone.0172722.Peer-Reviewed Original ResearchConceptsClick reactionClick chemistryCopper-free click reactionCopper-catalyzedAzide groupsBiomolecule attachmentReporter groupNP surfaceTargeted nanoparticlesNanoparticlesBioactive groupsMultifunctional nanomaterialsBiomedical applicationsSynthesisIntermediateReactionChemistryNanomaterialsBiomoleculesAlkynesCombination of techniquesCell surface receptorsAzideTherapeutic agentsClick