2024
Free‐breathing 3D cardiac extracellular volume (ECV) mapping using a linear tangent space alignment (LTSA) model
Lee W, Han P, Marin T, Mounime I, Eslahi S, Djebra Y, Chi D, Bijari F, Normandin M, Fakhri G, Ma C. Free‐breathing 3D cardiac extracellular volume (ECV) mapping using a linear tangent space alignment (LTSA) model. Magnetic Resonance In Medicine 2024 PMID: 39402014, DOI: 10.1002/mrm.30284.Peer-Reviewed Original ResearchExtracellular volume mappingContrast agent injectionExtracellular volumeGradient echo readoutECV mapsAgent injectionWhole heartEcho readoutExtracellular volume valuesVoxel-by-voxelInversion recovery sequenceSpatial resolutionScan timeImaging timeIn vivo studiesHealthy volunteersModel-based methodsRecovery sequenceInjectionReadout
2019
Renal clearable nanochelators for iron overload therapy
Kang H, Han M, Xue J, Baek Y, Chang J, Hu S, Nam H, Jo M, El Fakhri G, Hutchens M, Choi H, Kim J. Renal clearable nanochelators for iron overload therapy. Nature Communications 2019, 10: 5134. PMID: 31723130, PMCID: PMC6853917, DOI: 10.1038/s41467-019-13143-z.Peer-Reviewed Original ResearchConceptsIron overloadIntravenous injectionDaily sc injectionsUrinary iron excretionSecondary iron overloadIron-overloaded miceAdverse side effectsIron chelatorsIron overload disordersGastrointestinal bleedingSC injectionIron excretionLiver fibrosisSide effectsKidney damageKidney failureIron overload therapyIron levelsToxic ironPharmacokinetic propertiesDeferoxamineNanochelatorKidneyExcretionInjection