2017
Feasibility study of using fall‐off gradients of early and late PET scans for proton range verification
Cho J, Grogg K, Min C, Zhu X, Paganetti H, Lee H, Fakhri G. Feasibility study of using fall‐off gradients of early and late PET scans for proton range verification. Medical Physics 2017, 44: 1734-1746. PMID: 28273345, PMCID: PMC5462437, DOI: 10.1002/mp.12191.Peer-Reviewed Original ResearchConceptsProton range verificationProton rangeMonte Carlo simulationsRange verificationFall-offIn-room positron emission tomographyCarlo simulationsResidual proton rangeDose fall-offPostirradiation delayPositron emission tomography imagingSOBP beamProton beamPositron emission tomographyPositron emission tomography scanPhantom studyIn-roomFunction of depthPhantomProtonOff-setMonteAcquisition timeBeamPositron emission tomography signal
2014
A Recommendation on How to Analyze In-Room PET for In Vivo Proton Range Verification Using a Distal PET Surface Method
Min C, Zhu X, Grogg K, Fakhri G, Winey B, Paganetti H. A Recommendation on How to Analyze In-Room PET for In Vivo Proton Range Verification Using a Distal PET Surface Method. Technology In Cancer Research & Treatment 2014, 14: 320-325. PMID: 25246517, PMCID: PMC4898041, DOI: 10.1177/1533034614547457.Peer-Reviewed Original ResearchConceptsIn vivo range verificationIn-room positron emission tomographyRange verificationBeam passageIn vivo proton range verificationIn-roomIn-room PET scannerPositron emission tomography activityProton beam rangeProton range verificationSingle-field treatmentsProton beam deliveryAverage range differencesBeam rangeBeam deliveryPET scannerRoot-mean-square deviationPositron emission tomographyBeamRange differencesLevel surfaceActive lineActivity levelsLocal variationsTreatment course
2013
Clinical Application of In-Room Positron Emission Tomography for In Vivo Treatment Monitoring in Proton Radiation Therapy
Min C, Zhu X, Winey B, Grogg K, Testa M, Fakhri G, Bortfeld T, Paganetti H, Shih H. Clinical Application of In-Room Positron Emission Tomography for In Vivo Treatment Monitoring in Proton Radiation Therapy. International Journal Of Radiation Oncology • Biology • Physics 2013, 86: 183-189. PMID: 23391817, PMCID: PMC3640852, DOI: 10.1016/j.ijrobp.2012.12.010.Peer-Reviewed Original ResearchConceptsIn-room positron emission tomographyProton therapyIn-roomPositron emission tomography scanIn-room PET scannerPassive scattering proton therapyShapes of target volumesPositron emission tomographyMC predictionBeam range uncertaintiesMeasured PET imagesMonte CarloProton radiation therapyLocal elemental compositionBiological washoutScan timeTreatment headTreatment verificationRange uncertaintiesTarget volumePET scan timePET scannerPET systemComputed tomographyMC results
2011
Monitoring proton radiation therapy with in-room PET imaging
Zhu X, España S, Daartz J, Liebsch N, Ouyang J, Paganetti H, Bortfeld T, Fakhri G. Monitoring proton radiation therapy with in-room PET imaging. Physics In Medicine And Biology 2011, 56: 4041-4057. PMID: 21677366, PMCID: PMC3141290, DOI: 10.1088/0031-9155/56/13/019.Peer-Reviewed Original ResearchConceptsIn-room positron emission tomographyIn-roomProton therapy treatment roomPositron emission tomography systemProton range verificationSoft tissue-equivalent materialMonte Carlo predictionsTissue-equivalent materialsPositron emission tomography acquisition timesProton radiation therapyPositron emission tomographyBiological washoutRange verificationProton therapyList-modeActivity distribution patternsPhantom studyTreatment roomPET acquisitionSoft tissue regionsIn vivo verificationDeep-siteOff-line modalityPositron emission tomography dataAdenoid cystic carcinoma