2021
Personalised, image-guided, noninvasive brain stimulation in gliomas: Rationale, challenges and opportunities
Sprugnoli G, Rossi S, Rotenberg A, Pascual-Leone A, El-Fakhri G, Golby A, Santarnecchi E. Personalised, image-guided, noninvasive brain stimulation in gliomas: Rationale, challenges and opportunities. EBioMedicine 2021, 70: 103514. PMID: 34391090, PMCID: PMC8365310, DOI: 10.1016/j.ebiom.2021.103514.Peer-Reviewed Original ResearchConceptsHigh-grade gliomasNeuronal activityBrain tumorsProximity of tumor cellsSlow tumor growthAggressive human cancersMalignant brain tumorsBrain stimulationTumor mitosisHealthy brain tissuePatient survivalMechanism of actionImage-guidedTumor cellsTumor growthSynaptic activityHuman cancersTumorTherapeutic interventionsClinical settingNoninvasive brain stimulationElectrical stimulationWhole-brain levelPatientsBrain tissue
2018
Real‐Time Imaging of Brain Tumor for Image‐Guided Surgery
Hu S, Kang H, Baek Y, Fakhri G, Kuang A, Choi H. Real‐Time Imaging of Brain Tumor for Image‐Guided Surgery. Advanced Healthcare Materials 2018, 7: e1800066. PMID: 29719137, PMCID: PMC6105507, DOI: 10.1002/adhm.201800066.Peer-Reviewed Original ResearchConceptsNormal tissuesBrain tumorsCompleteness of surgical resectionDifferentiate cancerous lesionsIncomplete tumor resectionReal-time image guidanceRemoval of normal tissueDecrease surgical complicationsOptical fluorescence imagingMalignant brain tumorsBrain tumor treatmentIntraoperative guidance techniquesImage-guided surgeryMagnetic resonance imagingResidual tumorResection marginsSurgical resectionPrognostic factorsTumor resectionOncologic surgeonsSurgical complicationsResection completenessImage guidanceImage-guidedAdjacent normal tissues
2014
Preliminary Investigation of CBCT Imaging Optimization for Image-Guided Radiation Therapy
Bian J, Sharp G, Park Y, Bortfeld T, Fakhri G. Preliminary Investigation of CBCT Imaging Optimization for Image-Guided Radiation Therapy. 2014, 1-4. DOI: 10.1109/nssmic.2014.7430871.Peer-Reviewed Original ResearchImage-guided radiation therapyCone-beam CTCone-beam CT image qualityImprove CBCT image qualityCBCT image qualityCone-beam CT imagesOptimization-based reconstruction algorithmsReduce patient doseImage qualityCBCT dataImages of improved qualityImaging doseReconstruction algorithmIterative reconstruction techniqueASD-POCSImage reconstruction algorithmPatient doseImprove image qualityRadiation therapyDose reductionRadiation doseImage-guidedDosePoor image qualityExposure levels