Hierarchical Organization of Tau and Amyloid Deposits in the Cerebral Cortex
Sepulcre J, Grothe M, Sabuncu M, Chhatwal J, Schultz A, Hanseeuw B, Fakhri G, Sperling R, Johnson K. Hierarchical Organization of Tau and Amyloid Deposits in the Cerebral Cortex. JAMA Neurology 2017, 74: 813-820. PMID: 28558094, PMCID: PMC5710537, DOI: 10.1001/jamaneurol.2017.0263.Peer-Reviewed Original ResearchConceptsHeteromodal areasTemporal lobeHarvard Aging Brain StudyHeteromodal association regionsAging Brain StudyCognitively normal participantsElderly brainsPositron emission tomographicPrimary somatomotor cortexDistribution volume ratioAlzheimer's diseaseTau depositionStandardized uptake value ratioVisual regionsNormal participantsAb depositionSomatomotor cortexTemporal areaPittsburgh compound BCarbon 11-labeled Pittsburgh Compound BBrain studiesAssociation regionsHuman brainPathological hallmarks of Alzheimer's diseaseCortical distributionBrain circuit–gene expression relationships and neuroplasticity of multisensory cortices in blind children
Ortiz-Terán L, Diez I, Ortiz T, Perez D, Aragón J, Costumero V, Pascual-Leone A, Fakhri G, Sepulcre J. Brain circuit–gene expression relationships and neuroplasticity of multisensory cortices in blind children. Proceedings Of The National Academy Of Sciences Of The United States Of America 2017, 114: 6830-6835. PMID: 28607055, PMCID: PMC5495230, DOI: 10.1073/pnas.1619121114.Peer-Reviewed Original ResearchConceptsBlind childrenFunctional connectivity analysisMultisensory integration areasSensory deprivationFunctional connectivity relationshipsProtein gene familyNetwork connectivity profilesPrimary sensory cortexSystems-level analysisNeuroplastic adaptationsMultisensory cortexFunctional connectivityConnectivity analysisHuman neuroplasticityConnectivity changesGene expression profilesConnectivity profilesNeural reorganizationSensory cortexGene familySighted controlsHuman brainCortexBiological basisGenetic underpinningsTau and amyloid β proteins distinctively associate to functional network changes in the aging brain
Sepulcre J, Sabuncu M, Li Q, Fakhri G, Sperling R, Johnson K. Tau and amyloid β proteins distinctively associate to functional network changes in the aging brain. Alzheimer's & Dementia 2017, 13: 1261-1269. PMID: 28366797, PMCID: PMC5623176, DOI: 10.1016/j.jalz.2017.02.011.Peer-Reviewed Original ResearchConceptsAging brainFunctional connectivityAlzheimer's disease-related pathologyCognitively normal individualsPositron emission tomography scanHyperconnected regionsFunctional network changesMisfolded tauDisease-related pathologyBrain areasEmission tomography scanAmyloid-bFunctional reorganizationB proteinHuman brainNeuronal circuitsTauBrainNeuronal functionNegative associationAmyloidCortical patternsNetwork changesElderly subjectsPositive association