2023
Association of Pathologic and Volumetric Biomarker Changes With Cognitive Decline in Clinically Normal Adults
Hanseeuw B, Jacobs H, Schultz A, Buckley R, Farrell M, Guehl N, Becker J, Properzi M, Sanchez J, Quiroz Y, Vannini P, Sepulcre J, Yang H, Chhatwal J, Gatchel J, Marshall G, Amariglio R, Papp K, Rentz D, Normandin M, Price J, Healy B, El Fakhri G, Sperling R, Johnson K. Association of Pathologic and Volumetric Biomarker Changes With Cognitive Decline in Clinically Normal Adults. Neurology 2023, 101: e2533-e2544. PMID: 37968130, PMCID: PMC10791053, DOI: 10.1212/wnl.0000000000207962.Peer-Reviewed Original ResearchConceptsAssociated with cognitive declineOlder adultsNon-AD pathologyCognitive declineHippocampal volumeCognitive dataPreclinical Alzheimer Cognitive CompositeInferior temporal tauProspective cohort studyClinically normal older adultsHarvard Aging Brain StudyPittsburgh compound B PET scansOvert cognitive impairmentAnalyzed dataNormal older adultsAging Brain StudyClinically normal adultsLongitudinal associationsAlzheimer's diseaseCohort studyMemory impairmentCognitive compositeCognitive impairmentHippocampal atrophyCognition
2022
Longitudinal hippocampal atrophy is associated with cognitive decline independently of amyloid and tau in neocortex
Hanseeuw B, Jacobs H, Schultz A, Buckley R, Properzi M, Becker A, Farrell M, Sanchez J, Papp K, Yang H, Chhatwal J, Price J, Fakhri G, Rentz D, Sperling R, Johnson K. Longitudinal hippocampal atrophy is associated with cognitive decline independently of amyloid and tau in neocortex. Alzheimer's & Dementia 2022, 18 DOI: 10.1002/alz.069271.Peer-Reviewed Original Research