2022
Identifying the individual metabolic abnormities from a systemic perspective using whole-body PET imaging
Sun T, Wang Z, Wu Y, Gu F, Li X, Bai Y, Shen C, Hu Z, Liang D, Liu X, Zheng H, Yang Y, El Fakhri G, Zhou Y, Wang M. Identifying the individual metabolic abnormities from a systemic perspective using whole-body PET imaging. European Journal Of Nuclear Medicine And Molecular Imaging 2022, 49: 2994-3004. PMID: 35567627, PMCID: PMC9106794, DOI: 10.1007/s00259-022-05832-7.Peer-Reviewed Original ResearchConceptsPET imagingNormal control databaseTotal-body imagingWhole-body PET imagingNon-invasive modalitySUV measurementsGastrointestinal bleedingMetabolic abnormitiesSystem abnormalitiesTotal bodyLung cancerHealthy subjectsMetabolic dysfunctionFocal lesionsCOVID-19 diseaseGlucose metabolismControl databaseSUV imagesPatientsAbnormal networkBiological mechanismsDiseasePETMetabolic connectivity
2021
Quantification of Myocardial Mitochondrial Membrane Potential Using PET
Pelletier-Galarneau M, Detmer F, Petibon Y, Normandin M, Ma C, Alpert N, El Fakhri G. Quantification of Myocardial Mitochondrial Membrane Potential Using PET. Current Cardiology Reports 2021, 23: 70. PMID: 33970353, PMCID: PMC8443083, DOI: 10.1007/s11886-021-01500-8.Peer-Reviewed Original ResearchDual-Cycle Constrained Bijective Vae-Gan For Tagged-To-Cine Magnetic Resonance Image Synthesis
Liu X, Xing F, Prince J, Carass A, Stone M, Fakhri G, Woo J. Dual-Cycle Constrained Bijective Vae-Gan For Tagged-To-Cine Magnetic Resonance Image Synthesis. 2011 IEEE International Symposium On Biomedical Imaging: From Nano To Macro 2021, 00: 1448-1452. PMID: 34707796, PMCID: PMC8547333, DOI: 10.1109/isbi48211.2021.9433852.Peer-Reviewed Original ResearchMR image synthesisAdversarial trainingImage synthesisVAE-GANMR imagingTagged MR imagesCine MR imagingMoving organsSuperior performanceMagnetic resonance imagingAcquisition timeCycle reconstructionHealthy subjectsResonance imagingAnatomical resolutionComparison methodMotion analysisTagged magnetic resonance imagingTissue segmentationImagesScanning session
2020
In vivo quantitative mapping of human mitochondrial cardiac membrane potential: a feasibility study
Pelletier-Galarneau M, Petibon Y, Ma C, Han P, Kim S, Detmer F, Yokell D, Guehl N, Normandin M, El Fakhri G, Alpert N. In vivo quantitative mapping of human mitochondrial cardiac membrane potential: a feasibility study. European Journal Of Nuclear Medicine And Molecular Imaging 2020, 48: 414-420. PMID: 32719915, PMCID: PMC7839097, DOI: 10.1007/s00259-020-04878-9.Peer-Reviewed Original ResearchConceptsMembrane potentialBolus injectionHealthy subjectsHematocrit levelsSerial venous blood samplesT1 mapping imagesVenous blood samplesExtracellular space fractionMethodsThirteen healthy subjectsDynamic PET acquisitionCellular membrane potentialGadolinium injectionPrognostic informationVentricular arrhythmiasHeart failureMyocardial hypertrophyMitochondrial membrane potentialCardiac diseaseIn vitro assessmentTherapy monitoringBlood concentrationsPET acquisitionImaging protocolBlood samplesPlasma tracer concentration
2019
Free-Breathing Three-Dimensional T1 Mapping of the Heart Using Subspace-Based Data Acquisition and Image Reconstruction
Han P, Horng D, Marin T, Petibon Y, Ouyang J, Fakhri G, Ma C. Free-Breathing Three-Dimensional T1 Mapping of the Heart Using Subspace-Based Data Acquisition and Image Reconstruction. Annual International Conference Of The IEEE Engineering In Medicine And Biology Society (EMBC) 2019, 00: 4008-4011. PMID: 31946750, DOI: 10.1109/embc.2019.8856511.Peer-Reviewed Original ResearchConceptsRespiratory motionRespiratory gatingLongitudinal relaxation timeSubspace-based methodsLow-rank tensorMagnetic resonance imagingRelaxation timeT1 mappingT)-spaceSubspace-basedSparsity constraintDynamic MR imagingReconstructed mapsSpatiotemporal correlationThree-dimensionalCardiac MRHealthy subjectsIn vivo dataMagnetizationResonance imagingImage functionMR imagingData acquisitionClinical applicationTensor
2017
Speech Map: a statistical multimodal atlas of 4D tongue motion during speech from tagged and cine MR images
Woo J, Xing F, Stone M, Green J, Reese T, Brady T, Wedeen V, Prince J, Fakhri G. Speech Map: a statistical multimodal atlas of 4D tongue motion during speech from tagged and cine MR images. Computer Methods In Biomechanics And Biomedical Engineering Imaging & Visualization 2017, 7: 361-373. PMID: 31328049, PMCID: PMC6640640, DOI: 10.1080/21681163.2017.1382393.Peer-Reviewed Original ResearchMotion fieldMotion estimationTongue motionAnatomical configurationComplex motion fieldsCourse of speechCine MR imagingMotion informationInternal motionsGlossectomy patientsHealthy subjectsCine MRITongue functionMR imagingSpeech mappingClinical applicationAnatomical referenceTime course of speechTime courseSpeech