2022
Network Tau spreading is vulnerable to the expression gradients of APOE and glutamatergic-related genes
Montal V, Diez I, Kim C, Orwig W, Bueichekú E, Gutiérrez-Zúñiga R, Bejanin A, Pegueroles J, Dols-Icardo O, Vannini P, El-Fakhri G, Johnson K, Sperling R, Fortea J, Sepulcre J. Network Tau spreading is vulnerable to the expression gradients of APOE and glutamatergic-related genes. Science Translational Medicine 2022, 14: eabn7273. PMID: 35895837, PMCID: PMC9942690, DOI: 10.1126/scitranslmed.abn7273.Peer-Reviewed Original ResearchConceptsTau spreadingIntracellular accumulation of tau proteinAccumulation of tau proteinAlzheimer's diseasePathological tau accumulationGenetic gradientGenetic dataTau proteinNeurofibrillary tanglesSynaptic genesTau accumulationGenetic traitsGenesDrug development strategiesExpression gradientIntracellular accumulationTauExpressionCognitively normal older participantsHuman brain cortexTanglesProteinApoTraitsAlzheimer
2018
Sequence Alterations of Cortical Genes Linked to Individual Connectivity of the Human Brain
Xin Q, Ortiz-Terán L, Diez I, Perez D, Ginsburg J, Fakhri G, Sepulcre J. Sequence Alterations of Cortical Genes Linked to Individual Connectivity of the Human Brain. Cerebral Cortex 2018, 29: 3828-3835. PMID: 30307489, PMCID: PMC6686751, DOI: 10.1093/cercor/bhy262.Peer-Reviewed Original ResearchConceptsGenetic sequence alterationsGene expression profilesSequence alterationsGenetic expression dataExpression profilesBrain regionsFunctional connectivity variabilityCortical genesCortical regionsAllen Brain AtlasExpression dataGenetic variationGenetic signaturesFunctional connectivity magnetic resonance imagingCortical areasDiscrete cortical regionsGenesGraph theory analysisFunctional profilesNeurobiological underpinningsSequenceDegree of individual variabilityBrain areasBrain individualizationBrain organization