2024
Acute Stress Increases Striatal Connectivity With Cortical Regions Enriched for μ and κ Opioid Receptors
Zhukovsky P, Ironside M, Duda J, Moser A, Null K, Dhaynaut M, Normandin M, Guehl N, El Fakhri G, Alexander M, Holsen L, Misra M, Narendran R, Hoye J, Morris E, Esfand S, Goldstein J, Pizzagalli D. Acute Stress Increases Striatal Connectivity With Cortical Regions Enriched for μ and κ Opioid Receptors. Biological Psychiatry 2024, 96: 717-726. PMID: 38395372, PMCID: PMC11339240, DOI: 10.1016/j.biopsych.2024.02.005.Peer-Reviewed Original ResearchMajor depressive disorderFunctional connectivityEffects of stressAcute stressK-opioid receptorsStriatal connectivityEtiology of major depressive disorderCortical regionsMontreal Imaging Stress TaskEffects of acute stressGlobal FCIncreased striatal connectivityVentral attention/salience networkAllen Human Brain AtlasDefault mode networkCortical connectivityHuman Brain AtlasMDD studiesDepressive disorderFrontoparietal networkNeurobiological effectsMode networkStress taskDimensional approachMDD risk
2022
Lower novelty-related locus coeruleus function is associated with Aβ-related cognitive decline in clinically healthy individuals
Prokopiou P, Engels-Domínguez N, Papp K, Scott M, Schultz A, Schneider C, Farrell M, Buckley R, Quiroz Y, El Fakhri G, Rentz D, Sperling R, Johnson K, Jacobs H. Lower novelty-related locus coeruleus function is associated with Aβ-related cognitive decline in clinically healthy individuals. Nature Communications 2022, 13: 1571. PMID: 35322012, PMCID: PMC8943159, DOI: 10.1038/s41467-022-28986-2.Peer-Reviewed Original ResearchConceptsCognitive declineLC activityLC-FCFunctional connectivityLocus coeruleusAssociated with altered neuronal activityNeuronal activityFace-name paradigmAD-related cognitive declineHuman imaging researchIn vivo neuronal activityLongitudinal cognitive dataAssociated with cognitive declineBeta-amyloid-PETIndividuals at-riskAlzheimer's diseaseCognitively unimpaired older individualsBeta-amyloidSubcortical regionsFunctional MRICognitive dataNeurofibrillary tauImaging researchHippocampusCognition
2019
Multi-Modal Signatures of Tau Pathology, Neuronal Fiber Integrity, and Functional Connectivity in Traumatic Brain Injury
Wooten D, Ortiz-Terán L, Zubcevik N, Zhang X, Huang C, Sepulcre J, Atassi N, Johnson K, Zafonte R, Fakhri G. Multi-Modal Signatures of Tau Pathology, Neuronal Fiber Integrity, and Functional Connectivity in Traumatic Brain Injury. Journal Of Neurotrauma 2019, 36: 3233-3243. PMID: 31210098, PMCID: PMC6857466, DOI: 10.1089/neu.2018.6178.Peer-Reviewed Original ResearchConceptsTraumatic brain injuryTraumatic brain injury subjectsDistribution volume ratioWhite matter integrityFunctional connectivityDiffusion tensor imagingPositron emission tomographyTBI subjectsResting-state functional magnetic resonance imagingResting state functional connectivityFunctional magnetic resonance imagingFractional anisotropyDecreased white matter integrityGroup of TBI subjectsIncreased functional connectivityFunctional MRI resultsGraph theory metricsBrain injuryLiving human brainMagnetic resonance imagingNoninvasive neuroimaging techniquesBrain regionsFunctional MRINeuroimaging techniquesDiffusion tractography imaging
2017
Frontostriatal and Dopamine Markers of Individual Differences in Reinforcement Learning: A Multi-modal Investigation
Kaiser R, Treadway M, Wooten D, Kumar P, Goer F, Murray L, Beltzer M, Pechtel P, Whitton A, Cohen A, Alpert N, Fakhri G, Normandin M, Pizzagalli D. Frontostriatal and Dopamine Markers of Individual Differences in Reinforcement Learning: A Multi-modal Investigation. Cerebral Cortex 2017, 28: 4281-4290. PMID: 29121332, PMCID: PMC6454484, DOI: 10.1093/cercor/bhx281.Peer-Reviewed Original ResearchConceptsDA transporterRL behaviourVentral striatumDA clearanceFunctional connectivityBinding potentialLevel of neurocognitive functioningIncreased intrinsic functional connectivityMulti-modal neuroimaging studiesResting-state functional connectivityPhasic DA activityStriatal DA transporterIntrinsic functional connectivityReinforcement learning behaviorMulti-modal investigationsFrontostriatal circuitsFrontostriatal connectivityFrontostriatal regionsOrbitofrontal cortexDA activityNeuroimaging studiesOrbitofrontal regionsDopamine markersNeurocognitive functionDopamineBrain circuit–gene expression relationships and neuroplasticity of multisensory cortices in blind children
Ortiz-Terán L, Diez I, Ortiz T, Perez D, Aragón J, Costumero V, Pascual-Leone A, Fakhri G, Sepulcre J. Brain circuit–gene expression relationships and neuroplasticity of multisensory cortices in blind children. Proceedings Of The National Academy Of Sciences Of The United States Of America 2017, 114: 6830-6835. PMID: 28607055, PMCID: PMC5495230, DOI: 10.1073/pnas.1619121114.Peer-Reviewed Original ResearchConceptsBlind childrenFunctional connectivity analysisMultisensory integration areasSensory deprivationFunctional connectivity relationshipsProtein gene familyNetwork connectivity profilesPrimary sensory cortexSystems-level analysisNeuroplastic adaptationsMultisensory cortexFunctional connectivityConnectivity analysisHuman neuroplasticityConnectivity changesGene expression profilesConnectivity profilesNeural reorganizationSensory cortexGene familySighted controlsHuman brainCortexBiological basisGenetic underpinningsTau and amyloid β proteins distinctively associate to functional network changes in the aging brain
Sepulcre J, Sabuncu M, Li Q, Fakhri G, Sperling R, Johnson K. Tau and amyloid β proteins distinctively associate to functional network changes in the aging brain. Alzheimer's & Dementia 2017, 13: 1261-1269. PMID: 28366797, PMCID: PMC5623176, DOI: 10.1016/j.jalz.2017.02.011.Peer-Reviewed Original ResearchConceptsAging brainFunctional connectivityAlzheimer's disease-related pathologyCognitively normal individualsPositron emission tomography scanHyperconnected regionsFunctional network changesMisfolded tauDisease-related pathologyBrain areasEmission tomography scanAmyloid-bFunctional reorganizationB proteinHuman brainNeuronal circuitsTauBrainNeuronal functionNegative associationAmyloidCortical patternsNetwork changesElderly subjectsPositive association