2024
The role of parvalbumin interneuron dysfunction across neurodegenerative dementias
Smeralda C, Pandit S, Turrini S, Reilly J, Palmisano A, Sprugnoli G, Hampel H, Benussi A, Borroni B, Press D, Rotenberg A, El Fakhri G, Koch G, Rossi S, Santarnecchi E. The role of parvalbumin interneuron dysfunction across neurodegenerative dementias. Ageing Research Reviews 2024, 101: 102509. PMID: 39306248, DOI: 10.1016/j.arr.2024.102509.Peer-Reviewed Original ResearchInterneuron dysfunctionCortical hyperexcitabilityTherapeutic targetCortical excitation/inhibition balanceRhythm disruptionFast-spikingPV+ cellsBasket neuronsPotential therapeutic targetInhibitory interneuronsExcitation/inhibition balanceOscillatory disruptionsSymptom onsetNovel biomarkersHyperexcitabilityDysfunctionNeuronal deathOscillatory activityDementia with Lewy bodiesPathophysiological frameworkClinical symptom onsetFrontotemporal dementia
2021
Gamma‐induction in frontotemporal dementia (GIFTeD) randomized placebo‐controlled trial: Rationale, noninvasive brain stimulation protocol, and study design
Assogna M, Sprugnoli G, Press D, Dickerson B, Macone J, Bonnì S, Borghi I, Connor A, Hoffman M, Grover N, Wong B, Shen C, Martorana A, O'Reilly M, Ruffini G, Fakhri G, Koch G, Santarnecchi E. Gamma‐induction in frontotemporal dementia (GIFTeD) randomized placebo‐controlled trial: Rationale, noninvasive brain stimulation protocol, and study design. Alzheimer's & Dementia: Translational Research & Clinical Interventions 2021, 7: e12219. PMID: 35141396, PMCID: PMC8813035, DOI: 10.1002/trc2.12219.Peer-Reviewed Original ResearchBehavioral variant FTDFrontotemporal dementiaPlacebo-controlled trialDiagnosis of behavioural variant frontotemporal dementiaBehavioral variant frontotemporal dementiaNoninvasive brain stimulation protocolsStructural magnetic resonance imagingBehavioural variant FTD patientsGamma oscillatory activityOscillatory brain activityMagnetic resonance imagingMouse model of frontotemporal dementiaBrain oscillatory patternsNon-invasive brain stimulationBrain glucose hypometabolismInstitutional review boardBrain stimulation protocolsBehavioral alterationsFrequency-specific mannerBrain activityBehavioral assessmentFluorodeoxyglucose (FDG)-positron emission tomographyCognitive functionRandomized placebo-controlled trialNeural activity