2024
Associations of Physical Activity Engagement with Cerebral Amyloid-β and Tau from Midlife
Gonzales M, Kojis D, Spartano N, Thibault E, DeCarli C, Fakhri G, Johnson K, Beiser A, Seshadri S. Associations of Physical Activity Engagement with Cerebral Amyloid-β and Tau from Midlife. Journal Of Alzheimer's Disease 2024, 100: 935-943. PMID: 39031362, DOI: 10.3233/jad-240322.Peer-Reviewed Original ResearchConceptsPhysical activity indexPhysical activity engagementAssociated with lower dementia riskPhysical activity index scoreAssociation of physical activityActive engagementPhysical activity levelsFramingham Heart StudyCross-sectional associationsCommunity-based cohortCardiovascular risk factorsDementia riskPhysical activityLifestyle interventionHeart StudyLinear regression modelsStratified analysisTau-PET retentionSelf-reportSex disparitiesActivity levelsLate lifeTau positron emission tomographyRisk factorsAge groupsAssociations of Plasma Tau with Amyloid and Tau PET: Results from the Community-Based Framingham Heart Study
Ramos-Cejudo J, Scott M, Tanner J, Pase M, McGrath E, Ghosh S, Osorio R, Thibault E, Fakhri G, Johnson K, Beiser A, Seshadri S. Associations of Plasma Tau with Amyloid and Tau PET: Results from the Community-Based Framingham Heart Study. Journal Of Alzheimer's Disease 2024, 100: 487-494. PMID: 38875034, DOI: 10.3233/jad-231320.Peer-Reviewed Original ResearchConceptsCommunity-based Framingham Heart StudyFramingham Heart StudyHeart StudyCross-sectional associationsPlasma total tauMiddle-aged participantsRisk of ADCognitively healthy individualsCommunity-basedCompound B (PiB)-PETMiddle-agedPositive associationPlasma tauParticipantsTau-PETAssociationTotal tau levelsAD brain pathologyTotal-tauHealthy individualsAPOEe4Tau levelsBurdenRhinal cortexPrecuneus regions
2023
Higher Dietary Inflammatory Index scores are associated with higher beta‐amyloid deposition in the Framingham Heart Study
Lent D, Beiser A, Yuan C, Jacques P, Ghosh S, Thibault E, Fakhri G, Decarli C, Johnson K, Vasan R, Seshadri S, Himali J, Jacob M. Higher Dietary Inflammatory Index scores are associated with higher beta‐amyloid deposition in the Framingham Heart Study. Alzheimer's & Dementia 2023, 19 DOI: 10.1002/alz.078284.Peer-Reviewed Original ResearchFood frequency questionnaireDietary Inflammatory Index scoresDietary inflammatory indexHigher Dietary Inflammatory Index scoresInflammatory index scoreSystemic chronic inflammationFramingham Heart StudyProgression of dementiaDII scoresFrequency questionnaireCross-sectional relationshipInflammatory indexInflammatory markersChronic inflammationDietary factorsHeart StudyHigher circulating cortisol is associated with amyloidogenesis in post‐menopausal women: The Framingham Heart Study
Salardini A, Zilli E, Himali J, Gonzales M, Himali D, Ghosh S, McGrath E, Buckley R, Satizabal C, Johnson K, Decarli C, Fakhri G, Vasan R, Seshadri S. Higher circulating cortisol is associated with amyloidogenesis in post‐menopausal women: The Framingham Heart Study. Alzheimer's & Dementia 2023, 19 DOI: 10.1002/alz.080594.Peer-Reviewed Original ResearchFramingham Heart StudyHeart StudyProspective cohort studyCross sectional studyPostmenopausal womenCognitively normal individualsPost-menopausal womenSectional studyAPOE4 statusAPOE4-positiveLongitudinal cohortSuperior temporal sulcusCortisol levelsMenopausal statusSecondary outcomesAlzheimer's diseaseAssociated with amyloidogenesisCortisol dysregulationBaseline plasma cortisolMorning plasma cortisolTertileFraminghamWomenAssess interactionsProgression of Alzheimer's disease