Design, Synthesis, and Characterization of Benzimidazole Derivatives as Positron Emission Tomography Imaging Ligands for Metabotropic Glutamate Receptor 2
Yuan G, Qu X, Zheng B, Neelamegam R, Afshar S, Iyengar S, Pan C, Wang J, Kang H, Ondrechen M, Poutiainen P, Fakhri G, Zhang Z, Brownell A. Design, Synthesis, and Characterization of Benzimidazole Derivatives as Positron Emission Tomography Imaging Ligands for Metabotropic Glutamate Receptor 2. Journal Of Medicinal Chemistry 2020, 63: 12060-12072. PMID: 32981322, PMCID: PMC8629109, DOI: 10.1021/acs.jmedchem.0c01394.Peer-Reviewed Original ResearchConceptsPotential positron emission tomographyBenzimidazole derivativesPositron emission tomography imaging ligandsExcellent selectivityImaging ligandsPositive allosteric modulatorsRadiochemical yieldBinding affinityMetabotropic glutamate receptor 2C]methyl iodideMolar activityLigandDerivativesRadiochemical purityGlutamate receptor 2Brain regionsAllosteric modulatorsPositron emission tomographyC]methylationRadiochemicalIodideBrain uptakeMGluR subtypesCompoundsBindingColorimetric biosensing of glucose in human serum based on the intrinsic oxidase activity of hollow MnO 2 nanoparticles
Chen L, Gao H, Bai Y, Wei W, Wang J, El Fakhri G, Wang M. Colorimetric biosensing of glucose in human serum based on the intrinsic oxidase activity of hollow MnO 2 nanoparticles. New Journal Of Chemistry 2020, 44: 15066-15070. DOI: 10.1039/d0nj02387f.Peer-Reviewed Original ResearchBiosensing of glucoseDetection of glucoseHuman serum samplesOxidase-like activityAnalysis of human serum samplesMnO 2 nanoparticlesGlucose oxidaseAbundant nanosheetsExcellent selectivityManganese dioxide nanoparticlesCatalytic propertiesAcidic mediumHuman serumColorimetric biosensingLinear responseColor reagentRoutine analysisColorimetric signalOxidize glucoseNanoparticlesConcentrations of glucoseSerum samplesChemical compoundsOxidase activityLow cost