2021
Detecting lumbar lesions in 99mTc‐MDP SPECT by deep learning: Comparison with physicians
Petibon Y, Fahey F, Cao X, Levin Z, Sexton‐Stallone B, Falone A, Zukotynski K, Kwatra N, Lim R, Bar‐Sever Z, Chemli Y, Treves S, Fakhri G, Ouyang J. Detecting lumbar lesions in 99mTc‐MDP SPECT by deep learning: Comparison with physicians. Medical Physics 2021, 48: 4249-4261. PMID: 34101855, DOI: 10.1002/mp.15033.Peer-Reviewed Original ResearchConceptsSingle-photon emission computed tomographyLow back painLumbar lesionsPediatric patientsTc-MDPEvaluate low back painCause of low back painTc-MDP scanLesion-presentEmission computed tomographyConvolutional neural networkClinical likelihoodBack painInterreader variabilityDeep convolutional neural networkLumbar locationLesionsStress lesionsFocal lesionsDeep learningPatientsLumbar stressPhysiciansDL systemsLROC studies
2018
Joint reconstruction of rest/stress myocardial perfusion SPECT
Lai X, Petibon Y, Fakhri G, Ouyang J. Joint reconstruction of rest/stress myocardial perfusion SPECT. Physics In Medicine And Biology 2018, 63: 135019. PMID: 29897044, PMCID: PMC6245543, DOI: 10.1088/1361-6560/aacc2f.Peer-Reviewed Original ResearchConceptsMyocardial perfusion imagingSingle photon emission computed tomographyReversible defectsSignal-to-noise ratioRest/stress SPECT myocardial perfusion imagingSPECT myocardial perfusion imagingConventional subtraction methodDefect detectionJoint methodPhoton emission computed tomographySubtraction methodReverse mappingClinical dose levelsEmission computed tomographyImprove defect detectionLow noiseNon-invasive assessmentClinical dosePerfusion defectsReduced doseImprove radiologists' performanceReconstruction frameworkRest imagesPerfusion imagingDose levels
2016
Tissue-Specific Near-Infrared Fluorescence Imaging
Owens E, Henary M, Fakhri G, Choi H. Tissue-Specific Near-Infrared Fluorescence Imaging. Accounts Of Chemical Research 2016, 49: 1731-1740. PMID: 27564418, PMCID: PMC5776714, DOI: 10.1021/acs.accounts.6b00239.Peer-Reviewed Original ResearchConceptsSingle-photon emission computed tomographyPositron emission tomographyVital tissuesReal-time intraoperative navigationReal-time image guidanceContrast agentsTargeted NIR fluorophoresEmission computed tomographyTissue-specific contrast agentsEffective imaging agentsTissue-specific targetingReal-time delineationIntraoperative successTargeted therapyImage guidanceTumor tissuesEPR effectIntraoperative navigationSurgical fieldClinical imaging technologyDiagnostic utilityClinical useEmission tomographySurgical spaceTarget tissues
2013
Dual-Tracer PET Using Generalized Factor Analysis of Dynamic Sequences
El Fakhri G, Trott C, Sitek A, Bonab A, Alpert N. Dual-Tracer PET Using Generalized Factor Analysis of Dynamic Sequences. Molecular Imaging And Biology 2013, 15: 666-674. PMID: 23636489, PMCID: PMC3812387, DOI: 10.1007/s11307-013-0631-1.Peer-Reviewed Original ResearchConceptsEmit gamma raysPositron emission tomographyNear-simultaneous imagingSingle-photon emissionBrain PET studiesGamma raysSingle-photon emission computed tomographyActivity distributionRaclopride studiesEmission computed tomographyPositron emission tomography radiopharmaceuticalsSimultaneous imagingD2 bindingFactor analysis of dynamic sequencesActivity estimationTime activity curvesRacloprideFDGRhesus monkeysEmission tomographyPET studiesActivation curveBrain metabolismEmissionSimulate human data
2012
Ready for prime time? Dual tracer PET and SPECT imaging.
Fakhri G. Ready for prime time? Dual tracer PET and SPECT imaging. Am J Nucl Med Mol Imaging 2012, 2: 415-7. PMID: 23145358, PMCID: PMC3484417.Peer-Reviewed Original ResearchSingle photon emission computed tomographyDual-isotope single photon emission computed tomographyPositron emission tomographyPhoton emission computed tomographyDual tracer positron emission tomographyEmission computed tomographyPositron emission tomography studiesAreas of brainSPECT/PET imagingOncologic imagingKeV photonsAnimal modelsDown-scatterClinical potentialEmission tomographyPET radiotracersClinical settingAssociated with physical factorsIn vivoAdult population