2024
Advances and Insights in Positron Emission Tomography Tracers for Metabotropic Glutamate Receptor 4 Imaging
Wang J, Li Y, Fakhri G. Advances and Insights in Positron Emission Tomography Tracers for Metabotropic Glutamate Receptor 4 Imaging. Journal Of Medicinal Chemistry 2024, 67: 10517-10529. PMID: 38924702, PMCID: PMC11290609, DOI: 10.1021/acs.jmedchem.3c02431.Peer-Reviewed Original ResearchConceptsPositive allosteric modulatorsPositron emission tomographyPositron emission tomography radioligandsAllosteric modulatorsMGluR4 positive allosteric modulatorsMetabotropic glutamate receptor subtype 4PET ligandNeurological disordersPositron emission tomography tracersEmission tomographySubtype 4Molecular imaging modalitiesEffective treatmentMetabotropicDisordersParent drugImaging modalitiesPET tracersMGluR4Therapeutic targetPositron emitting radioisotopesSelection of lead compoundsLiving subjectsPositronQuantitative accuracy
2019
Fluorometric Imaging for Early Diagnosis and Prognosis of Rheumatoid Arthritis
Lee J, Jung S, Park G, Bao K, Hyun H, Fakhri G, Choi H. Fluorometric Imaging for Early Diagnosis and Prognosis of Rheumatoid Arthritis. Advanced Science 2019, 7: 1902267. PMID: 31921569, PMCID: PMC6947695, DOI: 10.1002/advs.201902267.Peer-Reviewed Original ResearchRheumatoid arthritisDisease progressionEarly diagnosisFluorometric imagingMouse model of RAPrognosis of rheumatoid arthritisTreatment of rheumatoid arthritisTissue-specific contrast agentsEffective treatment of rheumatoid arthritisModel of RAMonitoring of disease progressionTreatment of RACourse of RAImaging of RAIrreversible joint damagePrognosis of RASystemic treatmentSystemic complicationsContinuous inflammationProgressive courseMonitoring structural damageBone resorptionMouse modelPrognosis of diseaseEffective treatment