2024
Flat Panel TOF-PET Detectors: a Simulation Study
Orehar M, Dolenec R, Fakhri G, Gascón D, Gola A, Korpar S, Križan P, Razdevšek G, Marin T, Chemli Y, Žontar D, Pestotnik R. Flat Panel TOF-PET Detectors: a Simulation Study. 2024, 00: 1-2. DOI: 10.1109/nss/mic/rtsd57108.2024.10658250.Peer-Reviewed Original ResearchTime resolutionAngular coverageFlat-panel detectorScintillation materialsGATE softwareAxial coverageBiograph VisionPanel detectorTotal-body coverageClinical scannerImage reconstructionDetectorReconstructed imagesHomogeneous contrastCylindrical scannerImage qualityState-of-the-artScintillationHigh-performance computingScannerPhantomResolutionCore hoursPositron emission tomographyGateDesign Optimisation of a Flat-Panel, Limited-Angle TOF-PET Scanner: A Simulation Study
Orehar M, Dolenec R, Fakhri G, Korpar S, Križan P, Razdevšek G, Marin T, Žontar D, Pestotnik R. Design Optimisation of a Flat-Panel, Limited-Angle TOF-PET Scanner: A Simulation Study. Diagnostics 2024, 14: 1976. PMID: 39272760, PMCID: PMC11487429, DOI: 10.3390/diagnostics14171976.Peer-Reviewed Original ResearchTime-of-flight positron emission tomographyTOF-PET scannerNEMA NU 2Evaluate spatial resolutionPET detectorsNU 2Scintillation materialsBiograph VisionRing scannerLimited-angleScanner designReadout levelsPoint sourcesFlat panel geometryClinical scannerSpatial resolutionReadout strategySingle-crystalImage qualityScintillationScannerFlat panelDesign parametersDetectorDesign optimisation
2022
Simulation study of a 50 ps panel TOF PET imager
Pestotnik R, Razdevšek G, Dolenec R, Fakhri G, Križan P, Majewski S, Studen A, Korpar S. Simulation study of a 50 ps panel TOF PET imager. Journal Of Instrumentation 2022, 17: c12010. DOI: 10.1088/1748-0221/17/12/c12010.Peer-Reviewed Original ResearchPET scannerGamma detectorGamma raysTime-of-flight positron emission tomographyState-of-the-art clinical PET scannersGamma detection efficiencyClinical PET scannerImaging large objectsImproved time resolutionArtifact-free imagesDifferent phantomsDetector arrangementTime-of-flightBiograph VisionImage quality parametersDetection efficiencyTiming accuracyTime resolutionDetectorFWHMPositron emission tomographyReconstructed imagesRaysPositron emission tomography imagingMultichannel systemOptimization of Design Parameters of Flat Panel Limited Angle TOF-PET Scanner: a Simulation Study
Orehar M, Dolenec R, Fakhri G, Gascón D, Gola A, Korpar S, Križan P, Razdevšek G, Pestotnik R. Optimization of Design Parameters of Flat Panel Limited Angle TOF-PET Scanner: a Simulation Study. 2022, 00: 1-4. DOI: 10.1109/nss/mic44845.2022.10399330.Peer-Reviewed Original ResearchImage quality phantomFlat-panel detectorGATE softwareRing scannerPanel detectorDetection chainState-of-the-artNEMA standardsOpen geometryImage reconstructionReconstructed imagesPositron emission tomographyState-of-the-art scannersScannerPhantomDetectorPhotodetectorsElectronNEMAMaterial costGatePositronCardiac PET/MR Basics
Petibon Y, Ma C, Ouyang J, El Fakhri G. Cardiac PET/MR Basics. 2022, 21-35. DOI: 10.1007/978-3-031-09807-9_2.Peer-Reviewed Original ResearchMeasuring organ motionPET motion correctionFront-end electronicsScintillation detectorOrgan motionMotion correctionAttenuation correctionPET/MR scannersAbility of MRISimultaneous imaging modalityPET/MR technologyAttenuation propertiesHybrid PET/MR scannerPET/MRPre-clinicalImaging modalitiesClinical applicationMRIOrgan systemsCardiac applicationsImaging opportunitiesCorrectionDetectorSpatiotemporal resolutionElectron
2021
Investigation of a Model-Based Time-Over-Threshold Technique for Phoswich Crystal Discrimination
Bouziri H, Pepin C, Koua K, Benhouria M, Paulin C, Ouyang J, Normandin M, Pratte J, Fakhri G, Lecomte R, Fontaine R. Investigation of a Model-Based Time-Over-Threshold Technique for Phoswich Crystal Discrimination. IEEE Transactions On Radiation And Plasma Medical Sciences 2021, 6: 393-403. PMID: 35372739, PMCID: PMC8974315, DOI: 10.1109/trpms.2021.3077412.Peer-Reviewed Original ResearchPulse shape discriminationCrystal identificationPhoswich detectorEnergy windowTime-over-threshold techniqueBroad energy windowCR-RC shaperCharge sensitive preamplifierFree running analogPhoswich assembliesLYSO scintillatorSensitive preamplifierCrystal discriminationAPD arraysShape discriminationEvent energyElectronic readoutTime of occurenceDecay timeLGSODetectorIncreasing pixelizationLYSODetection front endCrystalA layered single-side readout depth of interaction time-of-flight-PET detector
Bläckberg L, Sajedi S, Fakhri G, Sabet H. A layered single-side readout depth of interaction time-of-flight-PET detector. Physics In Medicine And Biology 2021, 66: 045025. PMID: 33570050, PMCID: PMC8130834, DOI: 10.1088/1361-6560/abd592.Peer-Reviewed Original ResearchConceptsDepth of interactionMulti-pixel photon counterDepth-of-interaction determinationDepth-of-interaction informationTime resolutionTime resolution valuesReduced crystal thicknessNon-DOI detectorsOptical photonsScintillator arrayPET detectorsPhoton counterCrystal pixelsReadout schemeCrystal arrayCrystal thicknessTransport simulationsDetectorPhotodetector arrayReadoutPixel sizePhotodetectorsResolution valuesFirst layerSignal amplitude
2020
Dynamic Cardiac SPECT for diagnostic and theranostics applications: latest results
Bläckberg L, Sajedi S, Anderson O, Feng Y, Fakhri G, Furenlid L, Sabet H. Dynamic Cardiac SPECT for diagnostic and theranostics applications: latest results. 2020, 00: 1-3. DOI: 10.1109/nss/mic42677.2020.9508002.Peer-Reviewed Original ResearchCsI:Tl crystalsMPPC arraysTl crystalsCsI:Tl scintillatorGamma-ray energiesCardiac SPECTCsI:TlLow energy resolutionCardiac SPECT imagingGamma cameraConventional gamma cameraResolution recovery techniquesSensL SiPMsEnergy resolutionStopping powerTl scintillatorDetector modulesReadout electronicsDynamic cardiac SPECTPinhole collimatorHigh power lasersPhantom studyCollimatorDetectorSiPMLimited-angle TOF-PET for intraoperative surgical applications: latest results
Sajedi S, Bläckberg L, Fakhri G, Sabet H. Limited-angle TOF-PET for intraoperative surgical applications: latest results. 2020, 00: 1-3. DOI: 10.1109/nss/mic42677.2020.9507853.Peer-Reviewed Original ResearchCoincidence time resolutionWater phantomTOF-PETSphere-to-background activity ratiosLesion phantomsPET detector moduleDepth of interactionPET detector technologySmall-area detectorsDiameter spheresTime-of-flight (TOFPhantom depthDetector modulesCrystal pixelsDetector technologyDetector headFlight (TOFTime resolutionPhantomReduce FNRDetectorConventional gammaLarger-areaPixel dimensionsAngle geometryHigh Sensitivity and High Resolution Dynamic Brain-Dedicated TOF-DOI PET Scanner
Bläckberg L, Sanchez D, Borghi G, Ballabriga R, Sajedi S, Gómez S, Fakhri G, Mazzi A, Paternoster G, Majewski S, Gola A, Gascón D, Sabet H. High Sensitivity and High Resolution Dynamic Brain-Dedicated TOF-DOI PET Scanner. 2020, 00: 1-5. DOI: 10.1109/nss/mic42677.2020.9507837.Peer-Reviewed Original ResearchCoincidence time resolutionField of viewFWHM coincidence timing resolutionTime resolutionIntrinsic detector resolutionLow noise ASICsLYSO scintillator arrayScintillator arraySiPM arrayDetector conceptLYSO crystalsDetector volumeDetector resolutionPET detectorsSiPM signalsReduce image blurringDOI positionsHigh PDEPET scannerTiming jitterSimultaneous high resolutionScanner designTransport simulationsDetectorIntegrated light sensors
2019
Limited-Angle TOF-PET for Intraoperative Surgical Application
Sajedi S, Bläckberg L, Vittum B, Devabhaktuni A, Nejad M, Fakhri G, Choi H, Sabet H. Limited-Angle TOF-PET for Intraoperative Surgical Application. 2019, 00: 1-4. DOI: 10.1109/nss/mic42101.2019.9059690.Peer-Reviewed Original ResearchSentinel lymph nodeHigh-resolution positron emission tomographyTOF-PETNear-infraredDetector ringDetector blockIncreasing acquisition timeTorso phantomHot spheresBottom detectorPositron emission tomographyTime resolutionDetectorIdentification of sentinel lymph nodesAcquisition timeSentinel lymph node identificationReconstructed imagesAccurate identification of sentinel lymph nodesActivity concentrationsWhole-body positron emission tomographyComplete tumor removalFalse negative rateImage slicesImprove patient recoveryPatient bedNew Detector Designs for High Resolution Brain PET
Bläckberg L, Sajedi S, Fakhri G, Sabet H. New Detector Designs for High Resolution Brain PET. 2019, 00: 1-5. DOI: 10.1109/nss/mic42101.2019.9059785.Peer-Reviewed Original ResearchLaser induced optical barriersLYSO:Ce crystalsScintillation light spreadIntrinsic resolutionDetector designCe crystalsOptical barrierBrain positron emission tomographyScintillationCrystal thicknessPhotodetector elementsTransverse resolutionDetectorPositron emission tomographyPhotodetectorsImproved positionLYSOCrystalReadoutResolutionLaserDependenceEmission tomographyExploring light confinement in laser-processed LYSO:Ce for photon counting CT application
Bläckberg L, Sajedi S, Mandl S, Mohan A, Vittum B, Fakhri G, Sabet H. Exploring light confinement in laser-processed LYSO:Ce for photon counting CT application. Physics In Medicine And Biology 2019, 64: 095020. PMID: 30897557, PMCID: PMC7191943, DOI: 10.1088/1361-6560/ab1213.Peer-Reviewed Original ResearchConceptsLaser induced optical barriersPhoton counting detectorsLight collection efficiencyCrystal pixelsLYSO:Ce detectorsHigh dose efficiencyPixel arrayCounting detectorsDetector designDose efficiencyOptical barrierPd edgePhotodetector (PDRough interfaceIncreased cross-talkCE detectorCT applicationsDetectorLaser ablationPixel sizeConfinementSmooth ablationLYSOSpatial resolutionCollection efficiency
2018
Light Spread Manipulation in Scintillators Using Laser Induced Optical Barriers
Bläckberg L, Moebius M, Fakhri G, Mazur E, Sabet H. Light Spread Manipulation in Scintillators Using Laser Induced Optical Barriers. IEEE Transactions On Nuclear Science 2018, 65: 2208-2215. PMID: 30905974, PMCID: PMC6424510, DOI: 10.1109/tns.2018.2809570.Peer-Reviewed Original ResearchDepth of interactionOptical barrierLYSO:Ce detectorsDepth-of-interaction informationLYSO:CeHigh-resolution PET imagesRefractive indexResolution PET imagingScintillation lightScintillation detectorDetector edgesReadout configurationDetector typesMonolithic crystalsBarrier patternsCrystal bulkCE detectorScintillationDetectorLYSOLiOBPixel arrayPET imagingLaserLight transport simulation
2017
Simulation Study of Partially Laser-Processed LYSO:Ce with Single-Side Readout
Bläckberg L, Fakhri G, Sabet H. Simulation Study of Partially Laser-Processed LYSO:Ce with Single-Side Readout. 2017, 00: 1-4. DOI: 10.1109/nssmic.2017.8532855.Peer-Reviewed Original ResearchGATE simulation of a new design of pinhole SPECT system for small animal brain imaging
Ozsahin D, Bläckberg L, Fakhri G, Sabet H. GATE simulation of a new design of pinhole SPECT system for small animal brain imaging. Journal Of Instrumentation 2017, 12: c01085-c01085. DOI: 10.1088/1748-0221/12/01/c01085.Peer-Reviewed Original ResearchFWHM spatial resolutionDetector modulesSPECT systemNEMA NU-4 protocolImage quality simulationsIntrinsic detector resolutionSpatial resolutionPinhole SPECT systemSmall-animal SPECT imagingAnimal SPECT imagingStationary SPECT systemAnimal brain imagingSmall animal brain imagingSmall animal imagingDetector resolutionSPECT detectorGATE simulationsDetector sizeSystem sensitivityPhantom evaluationResolution recoveryFOV sizeDetectorAnimal imagingFWHM
2016
Scintillator-Based Photon Counting Detector: Is it Feasible?
Bläckberg L, Moebius M, Moghadam N, Uzun-Ozsahin D, Mazur E, Fakhri G, Sabet H. Scintillator-Based Photon Counting Detector: Is it Feasible? 2016, 1-5. DOI: 10.1109/nssmic.2016.8069382.Peer-Reviewed Original ResearchLaser induced optical barriersPhoton counting detectorsScintillator arrayOptical barrierBarrier refractive indexRefractive indexApplication Specific Integrated CircuitFast decay timeHigh light outputBuilt-in photodiodeScintillation lightLYSO crystalsCounting detectorsScintillator pixelsEnergy windowAtomic numberScintillationDecay timeLight outputLaserDetectorTransparent crystalsCrystalIntegrated circuitsLaser cutting techniqueNovel laser‐processed CsI:Tl detector for SPECT
Sabet H, Bläckberg L, Uzun-Ozsahin D, El-Fakhri G. Novel laser‐processed CsI:Tl detector for SPECT. Medical Physics 2016, 43: 2630-2638. PMID: 27147372, PMCID: PMC5148208, DOI: 10.1118/1.4947294.Peer-Reviewed Original ResearchConceptsOptical barrierPeak-to-valley (P/VCsI:Tl crystalsCrystal bulkMultipixel photon counterPixel-like patternScintillation lightEnergy resolutionKeV gammasPixelated scintillatorScintillator samplesPhoton counterTL detectorsTl crystalsFabricated detectorScintillationCrystal thicknessSpatial resolutionPixel arrayDetectorBarrier patternsFabricated arraysCSICrystalBulk
2015
A Sub-MM Spatial Resolution LYSO: CE Detector for Small Animal PET
Sabet H, Bläckberg L, Ozsahin D, Sitek A, El-Fakhri G. A Sub-MM Spatial Resolution LYSO: CE Detector for Small Animal PET. 2015, 1-4. DOI: 10.1109/nssmic.2015.7582201.Peer-Reviewed Original ResearchLaser induced optical barriersOptical barrierLYSO:Ce crystalsIncident gamma raysLYSO:CeInter-pixel gapPixelated scintillatorLYSO crystalsPET detectorsPixelated crystalsCe crystalsGamma raysSub-mmMechanical pixelationLYSOCE detectorSimulation codeBarrier sizeAnimal PETHigh-spatial resolutionScintillationSmall-animal PETDetectorLaser energy densityEnergy density
2008
SU‐GG‐I‐74: New IAEA Document On Acceptance Testing, Quality Assurance and Quality Control for PET and PET/CT Systems
Fakhri G, Fulton R, Gray J, Marengo M, Zimmerman B, Dondi M, McLean I, Palm S. SU‐GG‐I‐74: New IAEA Document On Acceptance Testing, Quality Assurance and Quality Control for PET and PET/CT Systems. Medical Physics 2008, 35: 2659-2659. DOI: 10.1118/1.2961472.Peer-Reviewed Original ResearchPET/CT scannerTime-of-flight systemDetector materialPET/CTPET/CT unitComputed tomographyPET indicatorPET/CT systemCT componentPET technologyCT dataNatural radioactivityLesion detectionRadioactivity concentrationPETQuality assuranceDefinition of applicationsIAEAIAEA documentsGuidelinesAcceptance testsReference valuesScannerLesionsDetector