Associations of Physical Activity Engagement with Cerebral Amyloid-β and Tau from Midlife
Gonzales M, Kojis D, Spartano N, Thibault E, DeCarli C, Fakhri G, Johnson K, Beiser A, Seshadri S. Associations of Physical Activity Engagement with Cerebral Amyloid-β and Tau from Midlife. Journal Of Alzheimer's Disease 2024, 100: 935-943. PMID: 39031362, DOI: 10.3233/jad-240322.Peer-Reviewed Original ResearchConceptsPhysical activity indexPhysical activity engagementAssociated with lower dementia riskPhysical activity index scoreAssociation of physical activityActive engagementPhysical activity levelsFramingham Heart StudyCross-sectional associationsCommunity-based cohortCardiovascular risk factorsDementia riskPhysical activityLifestyle interventionHeart StudyLinear regression modelsStratified analysisTau-PET retentionSelf-reportSex disparitiesActivity levelsLate lifeTau positron emission tomographyRisk factorsAge groupsAssociations of cerebral amyloid beta and tau with cognition from midlife
Gonzales M, O'Donnell A, Ghosh S, Thibault E, Tanner J, Satizabal C, Decarli C, Fakhri G, Johnson K, Beiser A, Seshadri S, Pase M. Associations of cerebral amyloid beta and tau with cognition from midlife. Alzheimer's & Dementia 2024, 20: 5901-5911. PMID: 39039896, PMCID: PMC11497641, DOI: 10.1002/alz.14060.Peer-Reviewed Original ResearchApolipoprotein E e4Associated with cognitionTau positron emission tomographyPositron emission tomographyWorsening cognitionCommunity-based cohortYoung adultsApolipoprotein EStudy investigated associationsPoor visuospatial skillsDementia preventionTargeted early interventionE4 statusCerebral amyloid-betaEffect modifiersHigher amyloidAPOE e4 carriersCognitive vulnerabilityAssociation of amyloidVisuospatial skillsResilience factorsEarly interventionYounger ageCognitionE4 carriers