2002
Quantitative Simultaneous 99MTc/123I Spect: Design Study and Validation With Monte Carlo Simulations and Physical Acquisitions
Fakhri G, Maksud P, Kijewski M, Zimmerman R, Moore S. Quantitative Simultaneous 99MTc/123I Spect: Design Study and Validation With Monte Carlo Simulations and Physical Acquisitions. IEEE Transactions On Nuclear Science 2002, 49: 2315. DOI: 10.1109/tns.2002.803819.Peer-Reviewed Original ResearchMonte Carlo simulationsBrain phantomCarlo simulationsSimultaneous dual-isotope imagingIterative ordered subsetsDigital brain phantomDual-isotope SPECT studyVariable collimator responseArtificial neural networkPhysical acquisitionEnergy windowNonuniform attenuationCollimator responseDual-isotope imagingPhantom acquisitionsScatter correctionClinical cameraNeural networkMontePhantomIsotope imagingCorrected projectionsSPECT studiesProjector/backprojectorClinical application
2001
Absolute Activity Quantitation From Projections Using an Analytical Approach: Comparison With Iterative Methods in Tc-99M and I-123 Brain SPECT
Fakhri G, Kijewski M, Moore S. Absolute Activity Quantitation From Projections Using an Analytical Approach: Comparison With Iterative Methods in Tc-99M and I-123 Brain SPECT. IEEE Transactions On Nuclear Science 2001, 48: 768. DOI: 10.1109/23.940161.Peer-Reviewed Original ResearchVariable collimator responseI-123 studiesOrdered subsets-expectation maximizationI-123Tc-99mTc-99Brain phantomAttenuation correctionAnthropomorphic brain phantomDigital brain phantomTc-99m studiesMonte Carlo simulated projectionsCollimator responseActivity quantitationPathological patientsBrain structuresBrain SPECTActivity distributionPoor spatial resolutionSPECT activityQuantitative accuracyFitting procedurePartial volume effectsCaudate nucleusCorpus callosumAbsolute activity quantitation in simultaneous 123I/99mTc brain SPECT.
El Fakhri G, Moore S, Maksud P, Aurengo A, Kijewski M. Absolute activity quantitation in simultaneous 123I/99mTc brain SPECT. Journal Of Nuclear Medicine 2001, 42: 300-8. PMID: 11216530.Peer-Reviewed Original ResearchMeSH KeywordsAlzheimer DiseaseBenzamidesBrainCerebellumCerebral CortexCerebrovascular CirculationCorpus CallosumHumansIodine RadioisotopesMonte Carlo MethodNeural Networks, ComputerParkinson DiseasePhantoms, ImagingPutamenPyrrolidinesRadiopharmaceuticalsSensitivity and SpecificityTechnetium Tc 99m ExametazimeTomography, Emission-Computed, Single-PhotonConceptsOrdered-subset expectation maximizationDistance-dependent collimator responseActivity quantitationActivity distributionIterative ordered-subsets expectation maximizationZubal brain phantomAsymmetric windowsSimulated normal populationPathological studiesDecay photonsBrain SPECTCollimator responseNonuniform attenuationDual-isotope imagingBrain phantomMonte Carlo simulationsCorpus callosumNormal populationPartial volume effectsCarlo simulationsCortical lobesAssessment of brain perfusionScatteringCross-talkBrain perfusionAbsolute Quantitation in Simultaneous 99mTc/123I Brain SPECT Using ANN: Design Optimization and Validation
Fakhri G, Maksud P, Moore S, Zimmerman R, Kijewski M. Absolute Quantitation in Simultaneous 99mTc/123I Brain SPECT Using ANN: Design Optimization and Validation. 2001, 3: 1429-1431. DOI: 10.1109/nssmic.2001.1008605.Peer-Reviewed Original ResearchMonte Carlo simulationsBrain phantomSimultaneous dual-isotope imagingDigital brain phantomDual-isotope SPECT studyVariable collimator responseCarlo simulationsNon-uniform attenuationI-123 imagingEnergy windowCollimator responseDual-isotope imagingPhantom acquisitionsOSEM algorithmArtificial neural networkPhysical acquisitionScatter correctionClinical cameraBrain structuresPhantomIsotope imagingMonteSPECT studiesActivity concentrationsTc-99
2000
Relative impact of scatter, collimator response, attenuation, and finite spatial resolution corrections in cardiac SPECT.
El Fakhri G, Buvat I, Benali H, Todd-Pokropek A, Di Paola R. Relative impact of scatter, collimator response, attenuation, and finite spatial resolution corrections in cardiac SPECT. Journal Of Nuclear Medicine 2000, 41: 1400-8. PMID: 10945534.Peer-Reviewed Original ResearchConceptsDepth-dependent collimator responseSpatial resolution correctionCollimator responseFinite spatial resolutionBull's-eye mapCardiac SPECTActivity quantitationAttenuation correctionScatter correctionResolution correctionSpatial resolutionCollimator response correctionsSignal-to-noise ratioFrequency-distance principleImpact of scatteringLeft ventricleMonte Carlo simulationsCardiac phantomScatteringCarlo simulationsLV cavityAbsolute quantitationImproved contrastLV regionsProcessing schemeAbsolute activity quantitation from projections using an analytical approach: comparison with iterative methods in brain SPECT
Fakhri G, Kijewski M, Moore S. Absolute activity quantitation from projections using an analytical approach: comparison with iterative methods in brain SPECT. 2011 IEEE Nuclear Science Symposium Conference Record 2000, 3: 18/7-1811 vol.3. DOI: 10.1109/nssmic.2000.949215.Peer-Reviewed Original ResearchVariable collimator responseI-123 studiesI-123Tc-99Attenuation correctionTc-99mBrain SPECTDigital brain phantomTc-99m studiesMonte Carlo simulated projectionsCollimator responseActivity quantitationActivity estimationBrain phantomOSEM algorithmBrain structuresActivity distributionAccurate quantitationPoor spatial resolutionSPECT activityFitting procedurePartial volume effectsCaudate nucleusCorpus callosumSpatial resolution
1999
Respective roles of scatter, attenuation, depth-dependent collimator response and finite spatial resolution in cardiac single-photon emission tomography quantitation: a Monte Carlo study
El Fakhri G, Buvat I, Pélégrini M, Benali H, Almeida P, Bendriem B, Todd-Pokropek A, Di Paola R. Respective roles of scatter, attenuation, depth-dependent collimator response and finite spatial resolution in cardiac single-photon emission tomography quantitation: a Monte Carlo study. European Journal Of Nuclear Medicine And Molecular Imaging 1999, 26: 437-446. PMID: 10382086, DOI: 10.1007/s002590050409.Peer-Reviewed Original ResearchConceptsDepth-dependent collimator responseCollimator responseMonte Carlo simulationsActivity underestimationSingle-photon emission tomographyCarlo simulationsSignal-to-noise ratioSpatial resolutionCardiac phantomFWHM spatial resolutionCardiac single-photon emission tomographyQuantitative accuracyAnthropomorphic cardiac phantomPhysical effectsInfluence of scatteringEffect of scatteringScatter countsFull-widthIncreased SNRPoor spatial resolutionScatteringMap homogeneityPhantomMonteImaging system