2024
PET imaging of M4 muscarinic acetylcholine receptors in rhesus macaques using [11C]MK-6884: Quantification with kinetic modeling and receptor occupancy by CVL-231 (emraclidine), a novel positive allosteric modulator
Belov V, Guehl N, Duvvuri S, Iredale P, Moon S, Dhaynaut M, Chakilam S, MacDonagh A, Rice P, Yokell D, Renger J, Fakhri G, Normandin M. PET imaging of M4 muscarinic acetylcholine receptors in rhesus macaques using [11C]MK-6884: Quantification with kinetic modeling and receptor occupancy by CVL-231 (emraclidine), a novel positive allosteric modulator. Cerebrovascular And Brain Metabolism Reviews 2024, 44: 1329-1342. PMID: 38477292, PMCID: PMC11342722, DOI: 10.1177/0271678x241238820.Peer-Reviewed Original ResearchConceptsPositive allosteric modulatorsReceptor occupancyNon-human primatesBinding potentialPositron emission tomographyMuscarinic acetylcholine receptorsAllosteric modulatorsNon-human primate brainM4 muscarinic acetylcholine receptorStriatal hyperdopaminergiaAcetylcholine receptorsBrain regionsCaudate nucleusTotal volume of distributionDose-dependent blockReference regionVolume of distributionPositron emission tomography imagingEmission tomographyReceptor levelsFunction of dosePET scansClinical trialsBlood-basedRhesus macaques
2005
Quantitative simultaneous 99mTc-ECD/123I-FP-CIT SPECT in Parkinson’s disease and multiple system atrophy
El Fakhri G, Habert M, Maksud P, Kas A, Malek Z, Kijewski M, Lacomblez L. Quantitative simultaneous 99mTc-ECD/123I-FP-CIT SPECT in Parkinson’s disease and multiple system atrophy. European Journal Of Nuclear Medicine And Molecular Imaging 2005, 33: 87-92. PMID: 16180033, DOI: 10.1007/s00259-005-1920-y.Peer-Reviewed Original ResearchConceptsMultiple system atrophyIdiopathic Parkinson's diseaseDopamine transporterDopamine transporter binding potentialNormal controlsVoxel-based statistical parametric mappingAsymmetry indexMultiple system atrophy patientsCompared to normal controlsCaudate nucleusDifferential diagnosis of idiopathic Parkinson’s diseaseDiagnosis of parkinsonian syndromesPatient-specific attenuationDiagnosis of idiopathic Parkinson's diseaseBinding potentialIdiopathic Parkinson's disease patientsDual-isotope SPECTVariable collimator responseParkinson's diseaseDifferential diagnosisDecreased perfusionStatistical parametric mappingPurposeThe purposeSystem atrophyParkinsonian syndromes
2001
Absolute Activity Quantitation From Projections Using an Analytical Approach: Comparison With Iterative Methods in Tc-99M and I-123 Brain SPECT
Fakhri G, Kijewski M, Moore S. Absolute Activity Quantitation From Projections Using an Analytical Approach: Comparison With Iterative Methods in Tc-99M and I-123 Brain SPECT. IEEE Transactions On Nuclear Science 2001, 48: 768. DOI: 10.1109/23.940161.Peer-Reviewed Original ResearchVariable collimator responseI-123 studiesOrdered subsets-expectation maximizationI-123Tc-99mTc-99Brain phantomAttenuation correctionAnthropomorphic brain phantomDigital brain phantomTc-99m studiesMonte Carlo simulated projectionsCollimator responseActivity quantitationPathological patientsBrain structuresBrain SPECTActivity distributionPoor spatial resolutionSPECT activityQuantitative accuracyFitting procedurePartial volume effectsCaudate nucleusCorpus callosum
2000
Scatter and cross-talk corrections in simultaneous Tc-99m/I-123 brain SPECT using constrained factor analysis and artificial neural networks
Fakhri G, Maksud P, Kijewski M, Haberi M, Todd-Pokropek A, Aurengo A, Moore S. Scatter and cross-talk corrections in simultaneous Tc-99m/I-123 brain SPECT using constrained factor analysis and artificial neural networks. IEEE Transactions On Nuclear Science 2000, 47: 1573-1580. DOI: 10.1109/23.873018.Peer-Reviewed Original ResearchSpectral factor analysisTc-99mEnergy window methodDigital brain phantomCross-talk correctionI-123 imagingUnscattered photonsTc-99m activityBrain phantomMonte Carlo simulationsI-123Dual-isotope studiesPhotonsCarlo simulationsTc-99Simultaneous imagingAssessment of brain perfusionCross-talkBrain structuresBrain SPECTArtificial neural networkBrain perfusionPhantomClinical potentialCaudate nucleusAbsolute activity quantitation from projections using an analytical approach: comparison with iterative methods in brain SPECT
Fakhri G, Kijewski M, Moore S. Absolute activity quantitation from projections using an analytical approach: comparison with iterative methods in brain SPECT. 2011 IEEE Nuclear Science Symposium Conference Record 2000, 3: 18/7-1811 vol.3. DOI: 10.1109/nssmic.2000.949215.Peer-Reviewed Original ResearchVariable collimator responseI-123 studiesI-123Tc-99Attenuation correctionTc-99mBrain SPECTDigital brain phantomTc-99m studiesMonte Carlo simulated projectionsCollimator responseActivity quantitationActivity estimationBrain phantomOSEM algorithmBrain structuresActivity distributionAccurate quantitationPoor spatial resolutionSPECT activityFitting procedurePartial volume effectsCaudate nucleusCorpus callosumSpatial resolution
1999
Monte Carlo evaluation of quantitation in simultaneous Tc-99m/I-123 brain SPECT using constrained spectral factor analysis
Fakhri G, Moore S, Kijewski M, Maksud P, Todd-Pokropek A. Monte Carlo evaluation of quantitation in simultaneous Tc-99m/I-123 brain SPECT using constrained spectral factor analysis. 2011 IEEE Nuclear Science Symposium Conference Record 1999, 3: 1392-1396 vol.3. DOI: 10.1109/nssmic.1999.842815.Peer-Reviewed Original ResearchSpectral factor analysisTc-99mEnergy window methodDigital brain phantomI-123 imagingUnscattered photonsTc-99m activityBrain phantomFiltered-backprojectionMonte Carlo simulationsPrimary spectraDual-isotope studiesI-123Monte Carlo evaluationPhotonsCarlo simulationsSimultaneous imagingMonteBrain structuresBrain SPECTTc-99PhantomCaudate nucleusSpectraPixel values