2021
High-Resolution Label-Free Molecular Imaging of Brain Tumor
Guo R, Ma C, Li Y, Zhao Y, Wang T, Li Y, Fakhri G, Liang Z. High-Resolution Label-Free Molecular Imaging of Brain Tumor. Annual International Conference Of The IEEE Engineering In Medicine And Biology Society (EMBC) 2021, 00: 3049-3052. PMID: 34891886, DOI: 10.1109/embc46164.2021.9630623.Peer-Reviewed Original ResearchConceptsMagnetic resonance spectroscopic imagingBrain tumorsIntra-tumoural metabolic heterogeneityAssessment of treatment efficacySmall-sized tumorsClinical applicationN-acetyl aspartateBrain tumor characterizationPotential clinical applicationsApplication of magnetic resonance spectroscopic imagingTumor characterizationMolecular imaging techniquesBrain metabolitesImaging of brain tumorsTumorTreatment efficacyClinical relevanceMetabolic imagingDiagnosed brain tumorsHigh-resolution metabolic imagingMetabolic heterogeneityTumor detectionMolecular imaging of brain tumorsLabel-free molecular imagingLabel-free molecular imaging techniquePersonalised, image-guided, noninvasive brain stimulation in gliomas: Rationale, challenges and opportunities
Sprugnoli G, Rossi S, Rotenberg A, Pascual-Leone A, El-Fakhri G, Golby A, Santarnecchi E. Personalised, image-guided, noninvasive brain stimulation in gliomas: Rationale, challenges and opportunities. EBioMedicine 2021, 70: 103514. PMID: 34391090, PMCID: PMC8365310, DOI: 10.1016/j.ebiom.2021.103514.Peer-Reviewed Original ResearchConceptsHigh-grade gliomasNeuronal activityBrain tumorsProximity of tumor cellsSlow tumor growthAggressive human cancersMalignant brain tumorsBrain stimulationTumor mitosisHealthy brain tissuePatient survivalMechanism of actionImage-guidedTumor cellsTumor growthSynaptic activityHuman cancersTumorTherapeutic interventionsClinical settingNoninvasive brain stimulationElectrical stimulationWhole-brain levelPatientsBrain tissue
2018
Real‐Time Imaging of Brain Tumor for Image‐Guided Surgery
Hu S, Kang H, Baek Y, Fakhri G, Kuang A, Choi H. Real‐Time Imaging of Brain Tumor for Image‐Guided Surgery. Advanced Healthcare Materials 2018, 7: e1800066. PMID: 29719137, PMCID: PMC6105507, DOI: 10.1002/adhm.201800066.Peer-Reviewed Original ResearchConceptsNormal tissuesBrain tumorsCompleteness of surgical resectionDifferentiate cancerous lesionsIncomplete tumor resectionReal-time image guidanceRemoval of normal tissueDecrease surgical complicationsOptical fluorescence imagingMalignant brain tumorsBrain tumor treatmentIntraoperative guidance techniquesImage-guided surgeryMagnetic resonance imagingResidual tumorResection marginsSurgical resectionPrognostic factorsTumor resectionOncologic surgeonsSurgical complicationsResection completenessImage guidanceImage-guidedAdjacent normal tissues