2022
Longitudinal hippocampal atrophy is associated with cognitive decline independently of amyloid and tau in neocortex
Hanseeuw B, Jacobs H, Schultz A, Buckley R, Properzi M, Becker A, Farrell M, Sanchez J, Papp K, Yang H, Chhatwal J, Price J, Fakhri G, Rentz D, Sperling R, Johnson K. Longitudinal hippocampal atrophy is associated with cognitive decline independently of amyloid and tau in neocortex. Alzheimer's & Dementia 2022, 18 DOI: 10.1002/alz.069271.Peer-Reviewed Original Research
2021
Locus coeruleus integrity as a proxy of initial tau burden: in vivo versus ex vivo observations
Jacobs H, Becker A, Kwong K, Engels N, Prokopiou P, Papp K, Properzi M, Hampton O, Sanchez J, Rentz D, Fakhri G, Normandin M, Bennett D, Sperling R, Johnson K. Locus coeruleus integrity as a proxy of initial tau burden: in vivo versus ex vivo observations. Alzheimer's & Dementia 2021, 17 DOI: 10.1002/alz.056391.Peer-Reviewed Original ResearchHarvard Aging Brain StudyMini-Mental State ExaminationLC integrityLocus coeruleusMini-Mental State Examination scoreNeuronal densityTangle densityLocus coeruleus integrityAging Brain StudyTau pathologyAlzheimer's diseaseAD-related processesVertex-wiseTemporal regionsBraak stageLC measurementsMini-MentalMCI/AD patientsState ExaminationBrain studiesPiB-PET imagingTau-PETPET measurementsPiB-PETTangle burden
2020
Tracking the origin of tau spread in the brain
Jacobs H, Becker A, Kwong K, Uquillas F, Papp K, Properzi M, Rentz D, Fakhri G, Sperling R, Johnson K. Tracking the origin of tau spread in the brain. Alzheimer's & Dementia 2020, 16 DOI: 10.1002/alz.037501.Peer-Reviewed Original ResearchEntorhinal cortexMemory declineLocus coeruleusHarvard Aging Brain StudyPosterior cingulate cortexProspective memory declineAD-related cognitive declineMedial temporal lobeAging Brain StudyTau spreadingAlzheimer's diseaseCingulate cortexLimbic regionsNeuropsychological assessmentCingulate regionsTau PET imagingLC integrityCognitive changesTau accumulationMediation analysisTemporal lobeEntorhinal tauIncreased ABCognitive declineBrain studies
2017
Hierarchical Organization of Tau and Amyloid Deposits in the Cerebral Cortex
Sepulcre J, Grothe M, Sabuncu M, Chhatwal J, Schultz A, Hanseeuw B, Fakhri G, Sperling R, Johnson K. Hierarchical Organization of Tau and Amyloid Deposits in the Cerebral Cortex. JAMA Neurology 2017, 74: 813-820. PMID: 28558094, PMCID: PMC5710537, DOI: 10.1001/jamaneurol.2017.0263.Peer-Reviewed Original ResearchConceptsHeteromodal areasTemporal lobeHarvard Aging Brain StudyHeteromodal association regionsAging Brain StudyCognitively normal participantsElderly brainsPositron emission tomographicPrimary somatomotor cortexDistribution volume ratioAlzheimer's diseaseTau depositionStandardized uptake value ratioVisual regionsNormal participantsAb depositionSomatomotor cortexTemporal areaPittsburgh compound BCarbon 11-labeled Pittsburgh Compound BBrain studiesAssociation regionsHuman brainPathological hallmarks of Alzheimer's diseaseCortical distribution