2021
Speech intelligibility loss due to amyotrophic lateral sclerosis: the effect of tongue movement reduction on vowel and consonant acoustic features
Rong P, Usler E, Rowe L, Allison K, Woo J, Fakhri G, Green J. Speech intelligibility loss due to amyotrophic lateral sclerosis: the effect of tongue movement reduction on vowel and consonant acoustic features. Clinical Linguistics & Phonetics 2021, 35: 1091-1112. PMID: 33427505, DOI: 10.1080/02699206.2020.1868021.Peer-Reviewed Original ResearchConceptsTarget wordsIntelligence declineSpeech intelligibilityPredictors of speech intelligibilityDysarthria secondary to amyotrophic lateral sclerosisMotor performanceHealthy controlsReduced speech intelligibilityAcoustic featuresPhonetic distinctionsSpeech soundsRobust predictorsTongue movementDisease-related changesSpeech intelligibility declinesAmyotrophic lateral sclerosisTongue dynamicsMeasurement typesReduced rangeImpaired tongue movementMovement reductionWordsTongue bladeVowelsSpeech
2018
Magnetic resonance imaging based anatomical assessment of tongue impairment due to amyotrophic lateral sclerosis: A preliminary study
Lee E, Xing F, Ahn S, Reese T, Wang R, Green J, Atassi N, Wedeen V, El Fakhri G, Woo J. Magnetic resonance imaging based anatomical assessment of tongue impairment due to amyotrophic lateral sclerosis: A preliminary study. The Journal Of The Acoustical Society Of America 2018, 143: el248-el254. PMID: 29716267, PMCID: PMC5895467, DOI: 10.1121/1.5030134.Peer-Reviewed Original ResearchConceptsDiffusion tensor imagingHigh-resolution magnetic resonance imagingMagnetic resonance imagingResonance imagingEffects of amyotrophic lateral sclerosisAmyotrophic lateral sclerosisTensor imagingAmyotrophic lateral sclerosis patientsFiber connectionsSpeechNeurological disordersLateral sclerosisStrain map of the tongue in normal and ALS speech patterns from tagged and diffusion MRI
Xing F, Prince J, Stone M, Reese T, Atassi N, Wedeen V, El Fakhri G, Woo J. Strain map of the tongue in normal and ALS speech patterns from tagged and diffusion MRI. Proceedings Of SPIE--the International Society For Optical Engineering 2018, 10574: 1057411. PMID: 29706684, PMCID: PMC5922778, DOI: 10.1117/12.2293028.Peer-Reviewed Original ResearchDiffusion tensor imagingAmyotrophic lateral sclerosis subjectsAmyotrophic lateral sclerosisNormal subjectsMagnetic resonance (MR) techniquesAmyotrophic lateral sclerosis patientsTagged magnetic resonance imagingMagnetic resonance imagingMR imaging techniquesMotion sequencesDeath of neuronsMotion fieldDiffusion tensor imaging dataSwallowing functionLines of actionTongue tissueResonance imagingFiber directionTongue musclesTongue motionSpeech patternsMotion atlasActive regionTensor imaging
2017
Subject-specific anatomical assessment of the human tongue in amyotrophic lateral sclerosis (ALS) by high-resolution MRI and diffusion tensor imaging
Lee E, Xing F, Ahn S, Reese T, Wang R, Green J, Atassi N, Wedeen V, Fakhri G, Woo J. Subject-specific anatomical assessment of the human tongue in amyotrophic lateral sclerosis (ALS) by high-resolution MRI and diffusion tensor imaging. The Journal Of The Acoustical Society Of America 2017, 142: 2639-2639. DOI: 10.1121/1.5014672.Peer-Reviewed Original ResearchHigh-resolution MRIDiffusion tensor imagingAmyotrophic lateral sclerosis subjectsAmyotrophic lateral sclerosisTensor imagingAmyotrophic lateral sclerosis patientsLateral sclerosisAnatomical assessmentSuperior longitudinal muscleNon-invasive imagingDeformable registrationMotor neuronsLongitudinal muscleFractional anisotropyMuscle fibersIrreversible neurological disorderB0 imagesNeurological disordersHuman tongueMRIMotor cortexTongueSclerosisMuscleAnatomical differences