2024
Acute Stress Increases Striatal Connectivity With Cortical Regions Enriched for μ and κ Opioid Receptors
Zhukovsky P, Ironside M, Duda J, Moser A, Null K, Dhaynaut M, Normandin M, Guehl N, El Fakhri G, Alexander M, Holsen L, Misra M, Narendran R, Hoye J, Morris E, Esfand S, Goldstein J, Pizzagalli D. Acute Stress Increases Striatal Connectivity With Cortical Regions Enriched for μ and κ Opioid Receptors. Biological Psychiatry 2024, 96: 717-726. PMID: 38395372, PMCID: PMC11339240, DOI: 10.1016/j.biopsych.2024.02.005.Peer-Reviewed Original ResearchMajor depressive disorderFunctional connectivityEffects of stressAcute stressK-opioid receptorsStriatal connectivityEtiology of major depressive disorderCortical regionsMontreal Imaging Stress TaskEffects of acute stressGlobal FCIncreased striatal connectivityVentral attention/salience networkAllen Human Brain AtlasDefault mode networkCortical connectivityHuman Brain AtlasMDD studiesDepressive disorderFrontoparietal networkNeurobiological effectsMode networkStress taskDimensional approachMDD risk
2018
Neurogenetic contributions to amyloid beta and tau spreading in the human cortex
Sepulcre J, Grothe M, d’Oleire Uquillas F, Ortiz-Terán L, Diez I, Yang H, Jacobs H, Hanseeuw B, Li Q, El-Fakhri G, Sperling R, Johnson K. Neurogenetic contributions to amyloid beta and tau spreading in the human cortex. Nature Medicine 2018, 24: 1910-1918. PMID: 30374196, PMCID: PMC6518398, DOI: 10.1038/s41591-018-0206-4.Peer-Reviewed Original ResearchConceptsAmyloid-betaGenetic profileIdentified distinct pathwaysTau positron emission tomography imagingTau propagationTau pathwayTau spreadingGenetic backgroundAllen Human Brain AtlasDistinct pathwaysAlzheimer's diseaseTauLipid metabolismAb accumulationAdult individualsPathwayHuman Brain AtlasPathological progressionTranscriptomeMechanisms of pathological progressionBetaAmyloidProteinopathiesNeuronal circuitsApo