2023
Recruited macrophages elicit atrial fibrillation
Hulsmans M, Schloss M, Lee I, Bapat A, Iwamoto Y, Vinegoni C, Paccalet A, Yamazoe M, Grune J, Pabel S, Momin N, Seung H, Kumowski N, Pulous F, Keller D, Bening C, Green U, Lennerz J, Mitchell R, Lewis A, Casadei B, Iborra-Egea O, Bayes-Genis A, Sossalla S, Ong C, Pierson R, Aster J, Rohde D, Wojtkiewicz G, Weissleder R, Swirski F, Tellides G, Tolis G, Melnitchouk S, Milan D, Ellinor P, Naxerova K, Nahrendorf M. Recruited macrophages elicit atrial fibrillation. Science 2023, 381: 231-239. PMID: 37440641, PMCID: PMC10448807, DOI: 10.1126/science.abq3061.Peer-Reviewed Original ResearchConceptsAtrial fibrillationStromal cellsMitral valve regurgitationHeart failureValve regurgitationInflammatory monocytesMacrophage expansionMonocyte migrationMouse atriaFibrillationHuman atriumAtriumCell-cell interaction analysisSingle-cell transcriptomesMiceCell compositionHypertensionTranscriptome changesImmunotherapySPP1CellsRegurgitationObesityPatientsArrhythmias
2021
GENETIC BACKGROUND DOMINATES FIBROTIC AORTIC REMODELING DURING ANGIOTENSIN-INDUCED HYPERTENSION IN MICE
Spronck B, Caulk A, Ramachandra A, Murtada S, Rojas A, He C, Bersi M, Tellides G, Humphrey J. GENETIC BACKGROUND DOMINATES FIBROTIC AORTIC REMODELING DURING ANGIOTENSIN-INDUCED HYPERTENSION IN MICE. Journal Of Hypertension 2021, 39: e54. DOI: 10.1097/01.hjh.0000744928.37440.18.Peer-Reviewed Original Research
2020
P.58 Genetic Background Dictates Aortic Fibrosis in Hypertensive Mice
Spronck B, Latorre M, Mehta S, Caulk A, Ramachandra A, Murtada S, Rojas A, He C, Jiang B, Wang M, Bersi M, Tellides G, Humphrey J. P.58 Genetic Background Dictates Aortic Fibrosis in Hypertensive Mice. Artery Research 2020, 26: s81-s82. DOI: 10.2991/artres.k.201209.068.Peer-Reviewed Original Research
2000
Right ventricle-sparing heart transplant: promising new technique for recipients with pulmonary hypertension
Elefteriades J, Lovoulos C, Tellides G, Goldstein L, Rocco E, Condos S, Kopf G. Right ventricle-sparing heart transplant: promising new technique for recipients with pulmonary hypertension. The Annals Of Thoracic Surgery 2000, 69: 1858-1863. PMID: 10892937, DOI: 10.1016/s0003-4975(00)01318-7.Peer-Reviewed Original ResearchConceptsRight heart failurePulmonary hypertensionRight heartHeart transplantationHeart failureLeft ventricleOrthotopic heart transplantationSevere pulmonary hypertensionStable sinus rhythmNative aortic valveUnsolved clinical problemPulmonary arterial connectionCardiac transplantationCardiopulmonary bypassArterial connectionsSinus rhythmAortic valveHypertensionClinical problemHeterotopic transplantationTransplantationVentricleEarly causeHeartRecipients