Complement C5 Inhibition Reduces T Cell–Mediated Allograft Vasculopathy Caused by Both Alloantibody and Ischemia Reperfusion Injury in Humanized Mice
Qin L, Li G, Kirkiles‐Smith N, Clark P, Fang C, Wang Y, Yu Z, Devore D, Tellides G, Pober J, Jane‐Wit D. Complement C5 Inhibition Reduces T Cell–Mediated Allograft Vasculopathy Caused by Both Alloantibody and Ischemia Reperfusion Injury in Humanized Mice. American Journal Of Transplantation 2016, 16: 2865-2876. PMID: 27104811, PMCID: PMC5075274, DOI: 10.1111/ajt.13834.Peer-Reviewed Original ResearchConceptsIschemia-reperfusion injuryAllograft vasculopathyEndothelial cell activationReperfusion injuryCell activationComplement C5 inhibitionNuclear factor kappa BSolid organ transplantsT cell infiltrationTerminal complement activationVCAM-1 expressionComplement C5 activationFactor kappa BNeutrophil infiltrationHumanized miceDiffuse stenosisIntraluminal thrombosisArterial graftsC5 inhibitionCell infiltrationHumanized modelNeointimal hyperplasiaOrgan transplantsAlloantibodiesNF-kBThe Critical Role of SENP1‐Mediated GATA2 DeSUMOylation in Graft Arteriosclerosis by Promoting Endothelial Activation
Qiu C, Wang Y, Zhu X, Song L, Zhang H, Qin L, Tellides G, Min W, Yu L. The Critical Role of SENP1‐Mediated GATA2 DeSUMOylation in Graft Arteriosclerosis by Promoting Endothelial Activation. The FASEB Journal 2016, 30 DOI: 10.1096/fasebj.30.1_supplement.165.3.Peer-Reviewed Original ResearchGraft arteriosclerosisEndothelial adhesion moleculesEC activationEndothelial activationAdhesion moleculesGA progressionNeointima formationClinical graft rejectionAorta transplantation modelEndothelial cell activationLeukocyte-endothelial adhesionConditional knockout miceDeficient graftsGraft failureGraft rejectionVasomotor dysfunctionEndothelial overexpressionEndothelial inflammationAllograft transplantationVascular occlusionEC dysfunctionTransplantation modelLeukocyte recruitmentVascular remodelingKnockout mice