1992
Oxygen transport during anemic hypoxia in pigs: effects of digoxin on metabolism
Saltiel A, Sanfilippo DJ, Hendler R, Lister G. Oxygen transport during anemic hypoxia in pigs: effects of digoxin on metabolism. American Journal Of Physiology 1992, 263: h208-h217. PMID: 1636760, DOI: 10.1152/ajpheart.1992.263.1.h208.Peer-Reviewed Original ResearchConceptsTissue hypoxiaO2 extractionBlood flowHigh-output cardiac failureWhole-body O2 consumptionO2 deficitFemoral venous lactateNormal ventricular functionEffect of digoxinHindlimb blood flowRelease of catecholaminesWhole bodyO2 consumptionDigoxin groupCatecholamine responsesSerum catecholaminesVenous lactateCardiac failureVentricular functionArterial lactateSevere anemiaCardiac outputCatecholamine secretionAnemic hypoxiaO2 demand
1989
Effect of hemoglobin concentration on critical cardiac output and oxygen transport
Heusser F, Fahey JT, Lister G. Effect of hemoglobin concentration on critical cardiac output and oxygen transport. American Journal Of Physiology 1989, 256: h527-h532. PMID: 2916686, DOI: 10.1152/ajpheart.1989.256.2.h527.Peer-Reviewed Original ResearchConceptsSystemic O2 transportPeripheral O2 extractionCardiac outputO2 extractionFractional O2 extractionHemoglobin concentrationArterial blood lactate concentrationBase-line cardiac outputBalloon-tipped catheterPacked red cellsBlood lactate concentrationO2 transportPhysiological anaemiaExchange transfusionAcute reductionRight atriumVenous PO2Relative anemiaLactate concentrationOld lambsRed cellsAnemiaProgressive decreaseBase lineO2 consumption
1985
A simple method for reducing cardiac output in the conscious lamb
Fahey J, Lister G. A simple method for reducing cardiac output in the conscious lamb. American Journal Of Physiology 1985, 249: h188-h192. PMID: 4014483, DOI: 10.1152/ajpheart.1985.249.1.h188.Peer-Reviewed Original ResearchConceptsCardiac outputBalloon inflationBalloon-tipped catheterSystemic venous returnArterial lactate concentrationSystemic blood flowResting cardiac outputSmall neck incisionStable cardiac outputDays of ageUnsedated lambsConscious lambsBlood pressureVenous returnBalloon deflationNeck incisionRight atriumJugular veinMetabolic variablesO2 extractionBlood flowAnimal survivalLactate concentrationO2 consumptionLambs