2023
IRF8 may be a useful marker for blastic plasmacytoid dendritic cell neoplasm, especially with weak CD123 expression
Tang H, Panse G, Braddock D, Perincheri S, Xu M, McNiff J. IRF8 may be a useful marker for blastic plasmacytoid dendritic cell neoplasm, especially with weak CD123 expression. Journal Of Cutaneous Pathology 2023, 50: 595-600. PMID: 37082914, DOI: 10.1111/cup.14439.Peer-Reviewed Original ResearchConceptsBlastic plasmacytoid dendritic cell neoplasmPlasmacytoid dendritic cell neoplasmDendritic cell neoplasmPunch biopsy specimenBiopsy specimenCell neoplasmsCase of BPDCNUseful markerTumor cellsTCL-1 expressionAtypical mononuclear cellsBone marrow involvementDiffuse dermal infiltrateDendritic cell lineagePotential diagnostic pitfallRegulatory factor 8TCL-1BPDCN casesCD123 expressionMarrow involvementDermal infiltrateCutaneous nodulesMyelodysplastic syndromeSkin nodulesMononuclear cells
2017
Clinicopathological analysis of ATRX, DAXX and NOTCH receptor expression in angiosarcomas
Panse G, Chrisinger JS, Leung CH, Ingram DR, Khan S, Wani K, Lin H, Lazar AJ, Wang W. Clinicopathological analysis of ATRX, DAXX and NOTCH receptor expression in angiosarcomas. Histopathology 2017, 72: 239-247. PMID: 28796347, DOI: 10.1111/his.13337.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAdolescentAdultAgedAged, 80 and overBiomarkers, TumorCo-Repressor ProteinsDisease-Free SurvivalFemaleHemangiosarcomaHumansKaplan-Meier EstimateMaleMiddle AgedMolecular ChaperonesNuclear ProteinsPrognosisReceptors, NotchX-linked Nuclear ProteinYoung AdultConceptsNotch2 expressionWorse disease-specific survivalWorse event-free survivalDisease-specific survivalEvent-free survivalMalignant vascular tumorsPoor clinical outcomeATRX lossCase of angiosarcomaDeep soft tissuesPathogenesis of angiosarcomaTumor suppressive roleProtein 6 expressionNotch receptor expressionMental retardation syndrome XMultiple genetic alterationsSite of originInhibition of NotchAdvanced diseaseCutaneous sitesClinical outcomesPrognostic significanceClinicopathological analysisSyndrome XVascular tumorsBasal cell carcinoma: CD56 and cytokeratin 5/6 staining patterns in the differential diagnosis with Merkel cell carcinoma
Panse G, McNiff JM, Ko CJ. Basal cell carcinoma: CD56 and cytokeratin 5/6 staining patterns in the differential diagnosis with Merkel cell carcinoma. Journal Of Cutaneous Pathology 2017, 44: 553-556. PMID: 28403527, DOI: 10.1111/cup.12950.Peer-Reviewed Original ResearchConceptsMerkel cell carcinomaBasal cell carcinomaCases of BCCCell carcinomaCD56 expressionCases of MCCHistopathological examinationNeuroendocrine differentiationNeuroendocrine tumorsDifferential diagnosisCD56Sensitive markerUseful markerCarcinomaPatchy expressionTumorsDifficult casesMarkersStainingExpressionWell‐differentiated neuroendocrine tumors in skin: Terminology and diagnostic utility of cytokeratin 5/6 and p63
Panse G, Cowper SE, Leffell DJ, Pulitzer M, Ko CJ. Well‐differentiated neuroendocrine tumors in skin: Terminology and diagnostic utility of cytokeratin 5/6 and p63. Journal Of Cutaneous Pathology 2017, 44: 557-562. PMID: 28417484, DOI: 10.1111/cup.12952.Peer-Reviewed Original ResearchConceptsCutaneous adnexal neoplasmsAdnexal neoplasmsNeuroendocrine tumorsAdnexal tumorsBenign skin adnexal tumorCutaneous adnexal tumorsAggressive metastatic diseaseLow-grade tumorsSkin adnexal tumorsMajority of casesMetastatic diseaseMetastatic adenocarcinomaCarcinoid tumorsCytokeratin 5/6Diagnostic challengeDifferential diagnosisImmunohistochemical stainsCK5/6Diagnostic utilityPrimary siteTumorsNeoplasmsFirst signWDNETsP63The role of phosphorylated signal transducer and activator of transcription 3 (pSTAT3) in peripheral nerve sheath tumours
Panse G, Leung CH, Ingram DR, Wani K, Torres KE, Lin H, Lazar AJ, Wang W. The role of phosphorylated signal transducer and activator of transcription 3 (pSTAT3) in peripheral nerve sheath tumours. Histopathology 2017, 70: 946-953. PMID: 27992966, DOI: 10.1111/his.13154.Peer-Reviewed Original ResearchConceptsMalignant peripheral nerve sheath tumorDisease-specific overall survivalEvent-free survivalPrimary malignant peripheral nerve sheath tumorPeripheral nerve sheath tumorsWorse event-free survivalKaplan-Meier methodNegative prognostic factorNerve sheath tumorsLog-rank testPeripheral nerve sheathParaffin-embedded tissue microarrayPhosphorylated STAT3 expressionPhosphorylated signal transducerMetastatic diseaseOverall survivalPrognostic factorsSheath tumorsAggressive diseaseNerve sheathPro-oncogenic transcription factorPrimary tumorDisease onsetTissue microarrayImmunohistochemical analysis