2023
IRF8 may be a useful marker for blastic plasmacytoid dendritic cell neoplasm, especially with weak CD123 expression
Tang H, Panse G, Braddock D, Perincheri S, Xu M, McNiff J. IRF8 may be a useful marker for blastic plasmacytoid dendritic cell neoplasm, especially with weak CD123 expression. Journal Of Cutaneous Pathology 2023, 50: 595-600. PMID: 37082914, DOI: 10.1111/cup.14439.Peer-Reviewed Original ResearchConceptsBlastic plasmacytoid dendritic cell neoplasmPlasmacytoid dendritic cell neoplasmDendritic cell neoplasmPunch biopsy specimenBiopsy specimenCell neoplasmsCase of BPDCNUseful markerTumor cellsTCL-1 expressionAtypical mononuclear cellsBone marrow involvementDiffuse dermal infiltrateDendritic cell lineagePotential diagnostic pitfallRegulatory factor 8TCL-1BPDCN casesCD123 expressionMarrow involvementDermal infiltrateCutaneous nodulesMyelodysplastic syndromeSkin nodulesMononuclear cellsPRAME immunohistochemistry can distinguish melanocytic pseudonests of lichenoid reactions from melanoma in situ
Roy S, Panse G, McNiff J. PRAME immunohistochemistry can distinguish melanocytic pseudonests of lichenoid reactions from melanoma in situ. Journal Of Cutaneous Pathology 2023, 50: 450-454. PMID: 36789669, DOI: 10.1111/cup.14407.Peer-Reviewed Original ResearchRecent Advances in the Classification of Gynecological Tract Tumors: Updates From the 5th Edition of the World Health Organization "Blue Book".
Parkash V, Aisagbonhi O, Riddle N, Siddon A, Panse G, Fadare O. Recent Advances in the Classification of Gynecological Tract Tumors: Updates From the 5th Edition of the World Health Organization "Blue Book". Archives Of Pathology & Laboratory Medicine 2023, 147: 1204-1216. PMID: 36596270, DOI: 10.5858/arpa.2022-0166-ra.Peer-Reviewed Original ResearchConceptsWorld Health Organization classificationOrganization classificationWorld Health OrganizationTract tumorsGynecological tumorsFemale genital tract tumorsHealth OrganizationGenital tract tumorsHuman papillomavirus associationFemale genital tumorsLower genital tractFallopian tube tumorsRoutine clinical practiceGenetic tumor syndromesSite of originGenital tumorsGenital tractDiagnostic criteriaGlandular lesionsClinical practiceTumor syndromeTumorsComprehensive updateSyndromeLesions
2022
Microsecretory adenocarcinoma: Cutaneous counterpart of a newly described salivary gland tumor with recurrent MEF2C::SS18 fusion
Panse G. Microsecretory adenocarcinoma: Cutaneous counterpart of a newly described salivary gland tumor with recurrent MEF2C::SS18 fusion. Journal Of Cutaneous Pathology 2022, 50: 188-190. PMID: 36308392, DOI: 10.1111/cup.14349.Commentaries, Editorials and LettersConceptsMicrosecretory adenocarcinomaSalivary gland tumorsGland tumorsLow-grade salivary gland tumorsHigh-grade featuresComplete surgical excisionUnique immunohistochemical profileMicrocystic tubulesCutaneous counterpartFibromyxoid stromaLocal recurrenceSurgical excisionHistopathological featuresIndolent tumorsImmunohistochemical profileClear cytoplasmUnique tumorOral cavityLuminal secretionsAccurate diagnosisTumorsSkinMolecular studiesVast majorityAdenocarcinomaGlobal assessment of IRF8 as a novel cancer biomarker
McQuaid DC, Panse G, Wang WL, Pinkus GS, Katz SG, Xu ML. Global assessment of IRF8 as a novel cancer biomarker. Human Pathology 2022, 122: 1-10. PMID: 35085599, PMCID: PMC10621657, DOI: 10.1016/j.humpath.2022.01.004.Peer-Reviewed Original ResearchConceptsBlastic plasmacytoid dendritic cell neoplasmInterferon regulatory factor 8Myeloid sarcomaDifferential diagnosisPlasmacytoid dendritic cell neoplasmDesmoplastic small round cell tumorSmall round cell tumorTriple-negative breast cancerStrong uniform expressionDendritic cell neoplasmBroad differential diagnosisNegative breast cancerRound cell tumorAbsence of CD34IHC expression patternsAcute monocytic leukemiaNovel immunohistochemical markerTypes of cancerRegulatory factor 8Cancer Genome AtlasNovel cancer biomarkersRetrospective studySynovial sarcomaCell tumorsPleomorphic sarcoma
2020
Cervical Pemphigus Vulgaris Presenting as Postmenopausal Bleeding
Smith SM, Moscarelli R, Panse G, Parkash V. Cervical Pemphigus Vulgaris Presenting as Postmenopausal Bleeding. International Journal Of Gynecological Pathology 2020, 40: 477-481. PMID: 33323852, DOI: 10.1097/pgp.0000000000000724.Peer-Reviewed Original ResearchConceptsPemphigus vulgarisGenital involvementMucocutaneous blistering diseaseRelapse/recurrenceLong-term survivalCervical involvementPostmenopausal bleedingBullous lesionsCervical originTreatment modalitiesBlistering diseaseUnnecessary interventionsOral cavityPatientsPostmenopausalSymptomsDiseasePemphigusInvolvementVulgarisHysterectomyBleedingCervixPresentingRecurrence
2017
Clinicopathological analysis of ATRX, DAXX and NOTCH receptor expression in angiosarcomas
Panse G, Chrisinger JS, Leung CH, Ingram DR, Khan S, Wani K, Lin H, Lazar AJ, Wang W. Clinicopathological analysis of ATRX, DAXX and NOTCH receptor expression in angiosarcomas. Histopathology 2017, 72: 239-247. PMID: 28796347, DOI: 10.1111/his.13337.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAdolescentAdultAgedAged, 80 and overBiomarkers, TumorCo-Repressor ProteinsDisease-Free SurvivalFemaleHemangiosarcomaHumansKaplan-Meier EstimateMaleMiddle AgedMolecular ChaperonesNuclear ProteinsPrognosisReceptors, NotchX-linked Nuclear ProteinYoung AdultConceptsNotch2 expressionWorse disease-specific survivalWorse event-free survivalDisease-specific survivalEvent-free survivalMalignant vascular tumorsPoor clinical outcomeATRX lossCase of angiosarcomaDeep soft tissuesPathogenesis of angiosarcomaTumor suppressive roleProtein 6 expressionNotch receptor expressionMental retardation syndrome XMultiple genetic alterationsSite of originInhibition of NotchAdvanced diseaseCutaneous sitesClinical outcomesPrognostic significanceClinicopathological analysisSyndrome XVascular tumorsDegradable bioadhesive nanoparticles for prolonged intravaginal delivery and retention of elvitegravir
Mohideen M, Quijano E, Song E, Deng Y, Panse G, Zhang W, Clark MR, Saltzman WM. Degradable bioadhesive nanoparticles for prolonged intravaginal delivery and retention of elvitegravir. Biomaterials 2017, 144: 144-154. PMID: 28829952, PMCID: PMC5581224, DOI: 10.1016/j.biomaterials.2017.08.029.Peer-Reviewed Original ResearchConceptsPolymer carrierPolymeric nanoparticlesIntravaginal deliveryBioadhesive nanoparticlesNanoparticlesHuman immunodeficiency virusPromising strategyProtective mucus layerReproductive tractFormulation 1Residence timePolyEpithelial cell populationsSite of actionImmunodeficiency virusRetentionIntravaginal administrationVaginal lumenMucosal surfacesSustained protectionTopical applicationSTD epidemicsElvitegravirHormone cyclesMucus layerThe skin as a window to the blood: Cutaneous manifestations of myeloid malignancies
Li AW, Yin ES, Stahl M, Kim TK, Panse G, Zeidan AM, Leventhal JS. The skin as a window to the blood: Cutaneous manifestations of myeloid malignancies. Blood Reviews 2017, 31: 370-388. PMID: 28732587, DOI: 10.1016/j.blre.2017.07.003.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsCutaneous manifestationsMyeloid malignanciesMyeloid diseasesCommon cutaneous manifestationStage of diseaseHematologists/oncologistsSignificant clinical implicationsMalignant hematopoietic cellsCutaneous involvementSkin manifestationsTargeted agentsSkin findingsClinical reviewCutaneous reactionsDermatologic findingsPrognostic valueImmune statusDiagnostic challengeEarly recognitionHematologic malignanciesMalignancyClinical implicationsDiseaseManifestationsHematopoietic cellsBasal cell carcinoma: CD56 and cytokeratin 5/6 staining patterns in the differential diagnosis with Merkel cell carcinoma
Panse G, McNiff JM, Ko CJ. Basal cell carcinoma: CD56 and cytokeratin 5/6 staining patterns in the differential diagnosis with Merkel cell carcinoma. Journal Of Cutaneous Pathology 2017, 44: 553-556. PMID: 28403527, DOI: 10.1111/cup.12950.Peer-Reviewed Original ResearchConceptsMerkel cell carcinomaBasal cell carcinomaCases of BCCCell carcinomaCD56 expressionCases of MCCHistopathological examinationNeuroendocrine differentiationNeuroendocrine tumorsDifferential diagnosisCD56Sensitive markerUseful markerCarcinomaPatchy expressionTumorsDifficult casesMarkersStainingExpressionWell‐differentiated neuroendocrine tumors in skin: Terminology and diagnostic utility of cytokeratin 5/6 and p63
Panse G, Cowper SE, Leffell DJ, Pulitzer M, Ko CJ. Well‐differentiated neuroendocrine tumors in skin: Terminology and diagnostic utility of cytokeratin 5/6 and p63. Journal Of Cutaneous Pathology 2017, 44: 557-562. PMID: 28417484, DOI: 10.1111/cup.12952.Peer-Reviewed Original ResearchConceptsCutaneous adnexal neoplasmsAdnexal neoplasmsNeuroendocrine tumorsAdnexal tumorsBenign skin adnexal tumorCutaneous adnexal tumorsAggressive metastatic diseaseLow-grade tumorsSkin adnexal tumorsMajority of casesMetastatic diseaseMetastatic adenocarcinomaCarcinoid tumorsCytokeratin 5/6Diagnostic challengeDifferential diagnosisImmunohistochemical stainsCK5/6Diagnostic utilityPrimary siteTumorsNeoplasmsFirst signWDNETsP63The role of phosphorylated signal transducer and activator of transcription 3 (pSTAT3) in peripheral nerve sheath tumours
Panse G, Leung CH, Ingram DR, Wani K, Torres KE, Lin H, Lazar AJ, Wang W. The role of phosphorylated signal transducer and activator of transcription 3 (pSTAT3) in peripheral nerve sheath tumours. Histopathology 2017, 70: 946-953. PMID: 27992966, DOI: 10.1111/his.13154.Peer-Reviewed Original ResearchConceptsMalignant peripheral nerve sheath tumorDisease-specific overall survivalEvent-free survivalPrimary malignant peripheral nerve sheath tumorPeripheral nerve sheath tumorsWorse event-free survivalKaplan-Meier methodNegative prognostic factorNerve sheath tumorsLog-rank testPeripheral nerve sheathParaffin-embedded tissue microarrayPhosphorylated STAT3 expressionPhosphorylated signal transducerMetastatic diseaseOverall survivalPrognostic factorsSheath tumorsAggressive diseaseNerve sheathPro-oncogenic transcription factorPrimary tumorDisease onsetTissue microarrayImmunohistochemical analysis
2011
Useful Sign to Diagnose Tinea Capitis-‘Ear Sign’
Agarwal U, Sitaraman S, Panse G, Bhola K, Besarwal R. Useful Sign to Diagnose Tinea Capitis-‘Ear Sign’. Indian Journal Of Pediatrics 2011, 79: 679-680. PMID: 21975656, DOI: 10.1007/s12098-011-0571-1.Peer-Reviewed Original Research