Well‐differentiated neuroendocrine tumors in skin: Terminology and diagnostic utility of cytokeratin 5/6 and p63
Panse G, Cowper SE, Leffell DJ, Pulitzer M, Ko CJ. Well‐differentiated neuroendocrine tumors in skin: Terminology and diagnostic utility of cytokeratin 5/6 and p63. Journal Of Cutaneous Pathology 2017, 44: 557-562. PMID: 28417484, DOI: 10.1111/cup.12952.Peer-Reviewed Original ResearchConceptsCutaneous adnexal neoplasmsAdnexal neoplasmsNeuroendocrine tumorsAdnexal tumorsBenign skin adnexal tumorCutaneous adnexal tumorsAggressive metastatic diseaseLow-grade tumorsSkin adnexal tumorsMajority of casesMetastatic diseaseMetastatic adenocarcinomaCarcinoid tumorsCytokeratin 5/6Diagnostic challengeDifferential diagnosisImmunohistochemical stainsCK5/6Diagnostic utilityPrimary siteTumorsNeoplasmsFirst signWDNETsP63The role of phosphorylated signal transducer and activator of transcription 3 (pSTAT3) in peripheral nerve sheath tumours
Panse G, Leung CH, Ingram DR, Wani K, Torres KE, Lin H, Lazar AJ, Wang W. The role of phosphorylated signal transducer and activator of transcription 3 (pSTAT3) in peripheral nerve sheath tumours. Histopathology 2017, 70: 946-953. PMID: 27992966, DOI: 10.1111/his.13154.Peer-Reviewed Original ResearchConceptsMalignant peripheral nerve sheath tumorDisease-specific overall survivalEvent-free survivalPrimary malignant peripheral nerve sheath tumorPeripheral nerve sheath tumorsWorse event-free survivalKaplan-Meier methodNegative prognostic factorNerve sheath tumorsLog-rank testPeripheral nerve sheathParaffin-embedded tissue microarrayPhosphorylated STAT3 expressionPhosphorylated signal transducerMetastatic diseaseOverall survivalPrognostic factorsSheath tumorsAggressive diseaseNerve sheathPro-oncogenic transcription factorPrimary tumorDisease onsetTissue microarrayImmunohistochemical analysis