2024
Concordance of provider chart notation and guideline-based classification of asthma severity
Kroll H, Feinberg T, Soffer G, Reznik M. Concordance of provider chart notation and guideline-based classification of asthma severity. Journal Of Asthma 2024, 61: 1402-1411. PMID: 38717912, DOI: 10.1080/02770903.2024.2353106.Peer-Reviewed Original ResearchAsthma severity classificationChart notationUrban primary careClassification of asthma severityFair-to-goodWeighted kappa coefficientGuideline-based criteriaPrimary careNAEPP guidelinesDiagnosed asthmaConvenience sampleGuideline-basedAsthma criteriaPositive predictive valueAsthma severityAssess concordanceGuideline classificationPhysiciansEvaluate concordanceSeverity classificationClinic patientsPrescribed treatmentNAEPPMcNemar testKappa coefficientAppropriate Selection of Antihistamines in the Management of Allergic Reactions in the Pediatric Emergency Room: a quality improvement initiative
Tepler E, Mehta M, Tiyyagura G, Goldman M, Powers E, Soffer G. Appropriate Selection of Antihistamines in the Management of Allergic Reactions in the Pediatric Emergency Room: a quality improvement initiative. Journal Of Allergy And Clinical Immunology 2024, 153: ab54. DOI: 10.1016/j.jaci.2023.11.192.Peer-Reviewed Original Research
2023
SOMETHING'S FISHY WITH THE FEED: AN IGE-MEDIATED ALLERGIC REACTION TO HUMAN MILK
Halperin-Goldstein S, Soffer G. SOMETHING'S FISHY WITH THE FEED: AN IGE-MEDIATED ALLERGIC REACTION TO HUMAN MILK. Annals Of Allergy Asthma & Immunology 2023, 131: s170. DOI: 10.1016/j.anai.2023.08.523.Peer-Reviewed Original ResearchAssociated with allergen exposureHuman milkAllergic reactionsCase description ARare case reportFood proteinsSkin prick testAllergy to peanutIgE-mediated reactionsIgE-mediated allergic reactionsIntermittent pruritusBreastfed infantsCase reportRespiratory distressPrick testLaboratory evidenceChildren's dietsFood allergyMother's dietAllergen exposureComplementary foodsDiet modificationInduce sensitizationFin fishAllergic symptomatologyRacial, Ethnic, and Socioeconomic Differences in Food Allergies in the US
Jiang J, Warren C, Brewer A, Soffer G, Gupta R. Racial, Ethnic, and Socioeconomic Differences in Food Allergies in the US. JAMA Network Open 2023, 6: e2318162. PMID: 37314805, PMCID: PMC10267771, DOI: 10.1001/jamanetworkopen.2023.18162.Peer-Reviewed Original ResearchConceptsNon-Hispanic Black individualsNon-Hispanic white individualsParent-reported food allergyFood allergyWhite individualsBlack individualsEpinephrine autoinjector useFood allergy outcomesSurvey-weighted proportionsEmergency department visitsCommon food allergensFood allergy reactionsPopulation-based surveyCross-sectional survey studySimilar symptom presentationsLower ratesAutoinjector useDepartment visitsClinical outcomesPhysician diagnosisAllergy outcomesRepresentative sampleAllergy reactionsMAIN OUTCOMEPrevalence ratesThe emerging role of child life specialists in the pediatric food allergy clinic
Mathew M, Stahl U, Soffer G. The emerging role of child life specialists in the pediatric food allergy clinic. Annals Of Allergy Asthma & Immunology 2023, 131: 296-297. PMID: 37209837, DOI: 10.1016/j.anai.2023.05.013.Peer-Reviewed Original Research
2022
Computational analysis to define efficacy & molecular mechanisms of 7, 4’- Dihydroxyflavone on eosinophilic esophagitis: Ex-vivo validation in human esophagus biopsies
Maskey A, Wang Z, Chen X, Dunkin D, Yang N, Soffer G, Yuan Q, Li X. Computational analysis to define efficacy & molecular mechanisms of 7, 4’- Dihydroxyflavone on eosinophilic esophagitis: Ex-vivo validation in human esophagus biopsies. Frontiers In Immunology 2022, 13: 1015437. PMID: 36591238, PMCID: PMC9797535, DOI: 10.3389/fimmu.2022.1015437.Peer-Reviewed Original ResearchConceptsLevels of TNFIL-6Abdominal painEosinophilic esophagitisBiopsy samplesAbnormal bowel movementsTreatment of EoEMain treatment optionDihydroxy flavonesSignificant reductionTraditional Chinese medicine practiceDietary eliminationEoE therapyGE refluxSwallowed steroidsBowel movementsEoE patientsEsophageal dysfunctionGI symptomsEosinophilic inflammationImmunological mechanismsSteroid treatmentUpper endoscopyIgE productionChinese medicine practiceSafety Considerations for Natural Products Commonly Used By Patients with Allergic Disease
Soffer G, Shroff P, Horwitz R. Safety Considerations for Natural Products Commonly Used By Patients with Allergic Disease. The Journal Of Allergy And Clinical Immunology In Practice 2022, 10: 3131-3138. PMID: 36174919, DOI: 10.1016/j.jaip.2022.09.025.Peer-Reviewed Original ResearchConceptsConventional medical therapyHealth care providersMedical therapyAllergic diseasesClinical commentaryAdverse reactionsDrug Administration requirementsCare providersSide effectsAlternative medicinePatientsDietary supplementsU.S. FoodAllergyAdministration requirementsMedicinal plantsNatural productsTherapyCliniciansSafety considerationsDiseaseInduction of Severe Eosinophilic Esophagitis and Multi-Organ Inflammation by Airborne Allergens is Associated with IL-4/IL-13 and CCL11 but Not IgE in Genetic Susceptible Mice
Maskey A, Srivastava K, Soffer G, Dunkin D, Yuan Q, Li X. Induction of Severe Eosinophilic Esophagitis and Multi-Organ Inflammation by Airborne Allergens is Associated with IL-4/IL-13 and CCL11 but Not IgE in Genetic Susceptible Mice. Journal Of Inflammation Research 2022, 15: 5527-5540. PMID: 36176352, PMCID: PMC9514888, DOI: 10.2147/jir.s372449.Peer-Reviewed Original ResearchAirborne allergensNormal controlsEosinophilic inflammationEosinophilic esophagitisTh2 cytokinesAntigen-specific IgE levelsCommon chronic inflammatory diseaseImportant pathologic roleMild eosinophilic inflammationSevere eosinophilic esophagitisSevere eosinophilic inflammationIL-4/ILBronchoalveolar lavage fluidChronic inflammatory diseaseMulti-organ inflammationGene-deficient miceChemokine gene expressionIgA levelsIgE levelsIgG levelsSerum totalSpecific IgETotal IgAWT miceLavage fluidA Flavonoid Compound 7, 4 Dihydroxy Flavone as a Potential Therapeutic for the Treatment and Management of EoE
Maskey A, Wang Z, Chen X, Dunkin D, Soffer G, Yuan Q, Li X. A Flavonoid Compound 7, 4 Dihydroxy Flavone as a Potential Therapeutic for the Treatment and Management of EoE. The FASEB Journal 2022, 36 DOI: 10.1096/fasebj.2022.36.s1.r4598.Peer-Reviewed Original ResearchLevels of TNFManagement of EoEIL-6Biopsy samplesAbnormal bowel movementsProlonged steroid useDihydroxy flavonesHigh relapse rateRisk of cancerAGE-RAGE pathwayHigh response rateSignificant reductionTraditional Chinese medicine practiceEase of administrationPathway analysisDietary eliminationOral steroidsSystemic steroidsAbdominal painBowel movementsEsophageal dysfunctionGI symptomsMaintenance therapyEosinophilic inflammationGastrointestinal refluxHealth disparities in pediatric food allergy
Tepler E, Wong KH, Soffer GK. Health disparities in pediatric food allergy. Annals Of Allergy Asthma & Immunology 2022, 129: 417-423. PMID: 35476967, DOI: 10.1016/j.anai.2022.04.022.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsPediatric food allergyFood allergyHealth disparitiesSocioeconomic disparitiesSocioeconomic statusOutcome of childrenLow socioeconomic statusGoogle Scholar databasesAllergen-free foodsLong-term managementAcute managementAllergy careOverall prevalenceFood assistance programsAllergyHealth outcomesScholar databasesGreater riskLiterature searchOriginal research articlesChildrenPossible interventionsPrevalenceCurrent literatureDiagnosisCharacteristics and prevalence of antibiotic allergies in patients with sickle cell disease: A single‐center retrospective study
Wong KH, Soffer GK. Characteristics and prevalence of antibiotic allergies in patients with sickle cell disease: A single‐center retrospective study. American Journal Of Hematology 2022, 97: e247-e249. PMID: 35358357, DOI: 10.1002/ajh.26555.Peer-Reviewed Original ResearchClinical experience with sesame oral immunotherapy and a quality-of-life assessment
You L, Soffer G, Factor J. Clinical experience with sesame oral immunotherapy and a quality-of-life assessment. Journal Of Food Allergy 2022, 4: 1-9. PMID: 39021386, PMCID: PMC11250642, DOI: 10.2500/jfa.2022.4.220003.Peer-Reviewed Original ResearchOral immunotherapyRespiratory reactionsMaintenance therapyGastrointestinal reactionsSesame allergyCutaneous reactionsFood Allergy QualityFurther prospective studiesYears of ageQuality of lifeFood-related anxietyAdverse eventsPatient chartsProspective studyLife QuestionnaireAdverse reactionsAllergic reactionsFemale genderClinical experiencePatientsDietary limitationsTherapyPrivate practiceU.S. populationOddsPeripheral Blood Cell Counts Predict Distinct Endoscopic Phenotypes In Eosinophilic Esophagitis
Shin J, Kaman K, Anthonypillai J, Soffer G, Kang I. Peripheral Blood Cell Counts Predict Distinct Endoscopic Phenotypes In Eosinophilic Esophagitis. Journal Of Allergy And Clinical Immunology 2022, 149: ab204. DOI: 10.1016/j.jaci.2021.12.670.Peer-Reviewed Original ResearchIgE Independent Induction of EoE by Airborne Antigens via Up-regulation of Th2 Responses
Maskey A, Srivastava K, Soffer G, Dunkin D, Yuan Q, Li X. IgE Independent Induction of EoE by Airborne Antigens via Up-regulation of Th2 Responses. Journal Of Allergy And Clinical Immunology 2022, 149: ab202. DOI: 10.1016/j.jaci.2021.12.665.Peer-Reviewed Original Research
2021
A Review of Post-treatment Lyme Disease Syndrome and Chronic Lyme Disease for the Practicing Immunologist
Wong KH, Shapiro ED, Soffer GK. A Review of Post-treatment Lyme Disease Syndrome and Chronic Lyme Disease for the Practicing Immunologist. Clinical Reviews In Allergy & Immunology 2021, 62: 264-271. PMID: 34687445, DOI: 10.1007/s12016-021-08906-w.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsPost-treatment Lyme disease syndromeChronic Lyme diseaseNon-specific symptomsLyme diseaseDisease syndromeBurgdorferi infectionCurrent Lyme diseaseUse of IVIGIntravenous immunoglobulin treatmentCompletion of therapyMajority of patientsMinority of patientsConstellation of symptomsBorrelia burgdorferi infectionB. burgdorferi infectionBorrelia burgdorferi sensu latoImmunoglobulin treatmentImmune dysregulationAntibiotic therapyMusculoskeletal painBurgdorferi sensu latoCognitive dysfunctionImmune systemInfected IxodesPatientsConcomitant cow's milk and beef food protein–induced enterocolitis syndrome in a young infant
You L, Shafi S, Soffer G. Concomitant cow's milk and beef food protein–induced enterocolitis syndrome in a young infant. Annals Of Allergy Asthma & Immunology 2021, 127: 504-505. PMID: 34153445, DOI: 10.1016/j.anai.2021.06.009.Peer-Reviewed Original ResearchReply to “Increasing diversity in peanut oral immunotherapy research and accessibility”
Soffer G, Afinogenova Y, Factor JM. Reply to “Increasing diversity in peanut oral immunotherapy research and accessibility”. The Journal Of Allergy And Clinical Immunology In Practice 2021, 9: 2133. PMID: 33966875, DOI: 10.1016/j.jaip.2021.02.011.Peer-Reviewed Original ResearchAn integrative medicine review of primary prevention of allergy in pediatrics
Boolchandani H, Horwitz R, Soffer G. An integrative medicine review of primary prevention of allergy in pediatrics. Complementary Therapies In Medicine 2021, 58: 102695. PMID: 33636296, DOI: 10.1016/j.ctim.2021.102695.Peer-Reviewed Original ResearchConceptsAtopic diseasesAllergic diseasesPrimary preventionIntegrative medicineIntegrative medicine approachesLong-term outcomesNarrative review articlePrevention of diseaseMedicine ReviewsCounseling patientsPediatric populationAllergy preventionMedicine approachDiseasePreventionAllergyMedicineReview articlePatientsPregnancyPediatricsPrevalenceSensitizationInfectious Complications Predict Premature CD8+ T-cell Senescence in CD40 Ligand-Deficient Patients
Shin JJ, Catanzaro J, Yonkof JR, Delmonte O, Sacco K, Shin MS, Reddy S, Whittington PJ, Soffer G, Mustillo PJ, Sullivan KE, Notarangelo LD, Abraham RS, Romberg N, Kang I. Infectious Complications Predict Premature CD8+ T-cell Senescence in CD40 Ligand-Deficient Patients. Journal Of Clinical Immunology 2021, 41: 795-806. PMID: 33495902, PMCID: PMC8329305, DOI: 10.1007/s10875-021-00968-x.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge of OnsetBiomarkersCase-Control StudiesCD40 LigandCD8-Positive T-LymphocytesCellular SenescenceChild, PreschoolGenes, X-LinkedGenetic Association StudiesGenetic Predisposition to DiseaseHumansImmune System DiseasesImmunophenotypingInfectionsPedigreePhenotypePrognosisReceptors, Antigen, T-CellYoung AdultConceptsT cell senescenceCD40L-deficient patientsImmunoglobulin G replacementHealthy controlsT cellsInfectious complicationsCD40L deficiencyT-cell receptor excision circle analysisPneumocystis jirovecii pneumonia prophylaxisCMV-specific proliferationPatient group 2Effector memory CD8Effective prophylactic strategyCytokine release assaysAdult healthy controlsEarly CD8Pneumonia prophylaxisProphylaxis adherenceResultsThree patientsProphylactic antibioticsSenescence-associated moleculesMemory CD8Childhood pneumoniaInfectious exposureRecurrent infectionsImmunoglobulin G food testing
Wong KH, Horwitz R, Soffer GK. Immunoglobulin G food testing. Annals Of Allergy Asthma & Immunology 2021, 126: 611-612. PMID: 33493642, DOI: 10.1016/j.anai.2021.01.022.Commentaries, Editorials and Letters