Computational analysis to define efficacy & molecular mechanisms of 7, 4’- Dihydroxyflavone on eosinophilic esophagitis: Ex-vivo validation in human esophagus biopsies
Maskey A, Wang Z, Chen X, Dunkin D, Yang N, Soffer G, Yuan Q, Li X. Computational analysis to define efficacy & molecular mechanisms of 7, 4’- Dihydroxyflavone on eosinophilic esophagitis: Ex-vivo validation in human esophagus biopsies. Frontiers In Immunology 2022, 13: 1015437. PMID: 36591238, PMCID: PMC9797535, DOI: 10.3389/fimmu.2022.1015437.Peer-Reviewed Original ResearchMeSH KeywordsAbdominal PainBiopsyChildEosinophilic EsophagitisGene Expression ProfilingHumansInterleukin-6Molecular Docking SimulationQuality of LifeTumor Necrosis Factor-alphaConceptsLevels of TNFIL-6Abdominal painEosinophilic esophagitisBiopsy samplesAbnormal bowel movementsTreatment of EoEMain treatment optionDihydroxy flavonesSignificant reductionTraditional Chinese medicine practiceDietary eliminationEoE therapyGE refluxSwallowed steroidsBowel movementsEoE patientsEsophageal dysfunctionGI symptomsEosinophilic inflammationImmunological mechanismsSteroid treatmentUpper endoscopyIgE productionChinese medicine practice