Induction of Severe Eosinophilic Esophagitis and Multi-Organ Inflammation by Airborne Allergens is Associated with IL-4/IL-13 and CCL11 but Not IgE in Genetic Susceptible Mice
Maskey A, Srivastava K, Soffer G, Dunkin D, Yuan Q, Li X. Induction of Severe Eosinophilic Esophagitis and Multi-Organ Inflammation by Airborne Allergens is Associated with IL-4/IL-13 and CCL11 but Not IgE in Genetic Susceptible Mice. Journal Of Inflammation Research 2022, 15: 5527-5540. PMID: 36176352, PMCID: PMC9514888, DOI: 10.2147/jir.s372449.Peer-Reviewed Original ResearchAirborne allergensNormal controlsEosinophilic inflammationEosinophilic esophagitisTh2 cytokinesAntigen-specific IgE levelsCommon chronic inflammatory diseaseImportant pathologic roleMild eosinophilic inflammationSevere eosinophilic esophagitisSevere eosinophilic inflammationIL-4/ILBronchoalveolar lavage fluidChronic inflammatory diseaseMulti-organ inflammationGene-deficient miceChemokine gene expressionIgA levelsIgE levelsIgG levelsSerum totalSpecific IgETotal IgAWT miceLavage fluid