2017
Extracellular renalase protects cells and organs by outside‐in signalling
Wang Y, Safirstein R, Velazquez H, Guo X, Hollander L, Chang J, Chen T, Mu J, Desir GV. Extracellular renalase protects cells and organs by outside‐in signalling. Journal Of Cellular And Molecular Medicine 2017, 21: 1260-1265. PMID: 28238213, PMCID: PMC5487909, DOI: 10.1111/jcmm.13062.Peer-Reviewed Original ResearchMeSH KeywordsBlood PressureCatecholaminesCytokinesHeart RateHumansKidneyMonoamine OxidaseNADPH OxidasesNeoplasmsOxidation-ReductionConceptsProtective effectNovel therapeutic strategiesCancer cell growthBlood pressureOrgan injuryJAK/STATHeart rateTherapeutic strategiesToxic injuryCytoprotective actionMitogen-activated protein kinase pathwayRenalaseTranslational opportunitiesTumor cellsCellular actionsProtein kinase BInitial reportProtein kinase pathwayInjuryKinase BOrgansKinase pathwayGrowth-related genesCell growthExtracellular renalase
1986
Effect of hyperketonemia on renal ammonia excretion in man
Desir G, Bratusch-Marrain P, DeFronzo R. Effect of hyperketonemia on renal ammonia excretion in man. Metabolism 1986, 35: 736-743. PMID: 3736414, DOI: 10.1016/0026-0495(86)90241-6.Peer-Reviewed Original ResearchConceptsUrinary ammonia excretionVenous pHBlood pHBicarbonate concentrationEffects of hyperketonemiaBaseline bloodAbsence of changesContinuous infusionRenal ammonia excretionMetabolic acidosisBeta-OHBBody weightDay 4Mumol/ExcretionInfusionUrine samplesSimilar increaseUrineHuman subjectsAmmonia excretionNADH ratioSubjectsSodium lactateMinutes