Renalase Lowers Ambulatory Blood Pressure by Metabolizing Circulating Adrenaline
Desir GV, Tang L, Wang P, Li G, Sampaio‐Maia B, Quelhas‐Santos J, Pestana M, Velazquez H. Renalase Lowers Ambulatory Blood Pressure by Metabolizing Circulating Adrenaline. Journal Of The American Heart Association 2012, 1: e002634. PMID: 23130169, PMCID: PMC3487338, DOI: 10.1161/jaha.112.002634.Peer-Reviewed Original ResearchSympathetic nervous systemBlood pressureHypotensive effectNervous systemAmbulatory blood pressureTreatment of hypertensionBlood pressure regulationNovel therapeutic modalitiesPlasma epinephrineVasoactive hormonesRecombinant renalaseCardiac diseaseSystemic pressureTherapeutic modalitiesVivo administrationDopamine precursorΑ-methyldopaPressure regulationRenalaseEpinephrineSingle nucleotide polymorphismsHypertensionNorepinephrineUnique small moleculesSingle amino acid mutation