2000
Close Association of the N Terminus of Kv1.3 with the Pore Region*
Yao X, Liu W, Tian S, Rafi H, Segal A, Desir G. Close Association of the N Terminus of Kv1.3 with the Pore Region*. Journal Of Biological Chemistry 2000, 275: 10859-10863. PMID: 10753881, DOI: 10.1074/jbc.275.15.10859.Peer-Reviewed Original ResearchConceptsN-terminusPore regionSteady-state protein levelsLarge single-channel conductanceVoltage-gated potassium channelsWild-type channelsShaker proteinCertain amino acidsChannel assemblyWild typeChannel proteinsChannel functionAmino acidsSingle-channel conductancePore blockersSpeed of inactivationTerminusProtein levelsDomain leadPore selectivityPotassium channelsProteinType channelsKinetic propertiesChannel conductance
1992
Isolation of putative voltage-gated epithelial K-channel isoforms from rabbit kidney and LLC-PK1 cells
Desir GV, Hamlin HA, Puente E, Reilly RF, Hildebrandt F, Igarashi P. Isolation of putative voltage-gated epithelial K-channel isoforms from rabbit kidney and LLC-PK1 cells. American Journal Of Physiology 1992, 262: f151-f157. PMID: 1733291, DOI: 10.1152/ajprenal.1992.262.1.f151.Peer-Reviewed Original ResearchConceptsDeduced amino acid sequenceAmino acid sequenceAcid sequenceVoltage-gated K channelsRabbit genomic DNAPutative transmembrane segmentsShaker-like genesPutative voltage sensorShaker gene familyVoltage-gated potassium channelsGene familyShaker proteinRenal epithelial cellsTransmembrane segmentsSequence similarityRabbit cDNAEpithelial cell lineSouthern analysisProtein sequencesLLC-PK1 cellsDifferent genesGenomic DNAKidney cDNACDNAS4 segment