2014
Renalase regulates peripheral and central dopaminergic activities
Quelhas-Santos J, Serrão MP, Soares-Silva I, Fernandes-Cerqueira C, Simões-Silva L, Pinho MJ, Remião F, Sampaio-Maia B, Desir GV, Pestana M. Renalase regulates peripheral and central dopaminergic activities. American Journal Of Physiology. Renal Physiology 2014, 308: f84-f91. PMID: 25411385, PMCID: PMC4338928, DOI: 10.1152/ajprenal.00274.2014.Peer-Reviewed Original ResearchConceptsKO miceUrinary excretionPlasma levelsDopaminergic activityIncreased Plasma LevelsPeripheral dopaminergic activityUrine catecholamine levelsRenal dopaminergic systemCentral dopaminergic activityL-type amino acid transporterWild-type miceAmino acid decarboxylase activityKnockout mouse modelRenalase deficiencyCatecholamine levelsDA outputUrinary dopamineAADC activityDopaminergic systemRenal cortexMouse modelDOPA ratioVivo administrationOverexpression of LAT1Amino acid transporters
1993
Immunocytochemical characterization of the high-affinity thiazide diuretic receptor in rabbit renal cortex
Ellison DH, Biemesderfer D, Morrisey J, Lauring J, Desir GV. Immunocytochemical characterization of the high-affinity thiazide diuretic receptor in rabbit renal cortex. American Journal Of Physiology 1993, 264: f141-f148. PMID: 8430824, DOI: 10.1152/ajprenal.1993.264.1.f141.Peer-Reviewed Original ResearchConceptsThiazide diuretic receptorRenal distal tubulesDistal tubulesUrinary NaCl excretionRenal cortical membranesThick ascending limbRabbit kidney cortexApical membraneThiazide diureticsRenal cortexRabbit renal cortexCortical membranesProximal tubulesAscending limbSubpopulation of cellsNaCl excretionThiazide receptorKidney cortexIntense stainingWestern blotMonoclonal antibodiesRabbit kidneyImmunocytochemical characterizationPrincipal cellsReceptors
1991
Solubilization and partial purification of the thiazide diuretic receptor from rabbit renal cortex
Ellison D, Morrisey J, Desir G. Solubilization and partial purification of the thiazide diuretic receptor from rabbit renal cortex. Biochimica Et Biophysica Acta 1991, 1069: 241-249. PMID: 1932064, DOI: 10.1016/0005-2736(91)90131-q.Peer-Reviewed Original ResearchConceptsHigh-affinity receptorRenal cortexCortical homogenatesDistal tubulesHigh-performance liquid chromatographyDistal tubule fragmentsRenal cortical microsomesRenal distal tubulesThiazide diuretic receptorRenal cortical membranesExclusion high performance liquid chromatographyRat renal cortexRenal cortical homogenatesCortical microsomesRabbit renal cortexReceptor densityCortical membranesSize-exclusion high-performance liquid chromatographyRabbit receptorThiazide receptorCl- transport pathwaysPercoll gradient centrifugationDiuretic drugsTubule fragmentsReceptors