2015
Identification of a Receptor for Extracellular Renalase
Wang L, Velazquez H, Chang J, Safirstein R, Desir GV. Identification of a Receptor for Extracellular Renalase. PLOS ONE 2015, 10: e0122932. PMID: 25906147, PMCID: PMC4407985, DOI: 10.1371/journal.pone.0122932.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryCell LineCytoprotectionDown-RegulationEpidermal Growth FactorEssential HypertensionHumansHypertensionMitogen-Activated Protein KinasesMonoamine OxidasePlasma Membrane Calcium-Transporting ATPasesPolymorphism, Single NucleotideProtein Interaction Domains and MotifsSignal TransductionConceptsAcute kidney injuryIntrinsic enzymatic activityMAPK signalingExtracellular renalaseHuman proximal tubular cell line HK-2Enzymatic activitySingle nucleotide gene polymorphismsAcute ischemic kidneyWild-type miceProtein-protein interactionsPlasma membrane ATPaseKidney injuryIschemic kidneyEssential hypertensionIschemic injuryCardiac injuryPMCA4b expressionRecombinant renalaseEpidermal growth factorType miceCardiac hypertrophyHK-2Control studyGene polymorphismsCell signaling
2011
Novel insights into the physiology of renalase and its role in hypertension and heart disease
Desir G. Novel insights into the physiology of renalase and its role in hypertension and heart disease. Pediatric Nephrology 2011, 27: 719-725. PMID: 21424526, DOI: 10.1007/s00467-011-1828-7.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseKidney diseaseResistant hypertensionSympathetic toneBlood pressureRecombinant renalaseSpontaneously Hypertensive Stroke-PronePlasma renalase levelsRenalase knockout mouseSystolic blood pressureModel of hypertensionPotent antihypertensive agentSevere cardiac hypertrophyRenalase deficiencyRenalase levelsRenal functionUrine catecholaminesEssential hypertensionSalt intakeStroke proneAntihypertensive agentsCatecholamine levelsRenal sodiumSingle dosePlasma levels
2010
Role of Novel Biomarkers in Chronic Kidney Disease: Renalase
Desir G. Role of Novel Biomarkers in Chronic Kidney Disease: Renalase. 2010, 309-316. DOI: 10.1007/978-88-470-1463-3_24.Peer-Reviewed Original ResearchChronic kidney diseaseBlood pressureKidney diseaseCardiac functionRenalase knockout mouseAcute kidney injurySevere cardiovascular complicationsCardiovascular complicationsKidney injuryEssential hypertensionCardiac injuryMyocardial injuryEarly biomarkersRenalase geneNovel biomarkersKnockout miceTherapeutic utilityRenalaseInjuryProtein expressionSingle nucleotide polymorphismsPreliminary dataDiseaseModest increaseBiomarkers
2009
Regulation of blood pressure and cardiovascular function by renalase
Desir GV. Regulation of blood pressure and cardiovascular function by renalase. Kidney International 2009, 76: 366-370. PMID: 19471322, DOI: 10.1038/ki.2009.169.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseGlomerular filtration rateBlood pressureKidney diseasePlasma catecholaminesCardiovascular functionKnockout miceEnd-stage kidney diseaseRenalase knockout mouseSingle nucleotide polymorphismsRenalase levelsCardiovascular riskEssential hypertensionFiltration rateCardiac functionCardiac ischemiaRenalase geneSignificant fallAnimal modelsRenalaseCatecholaminesHypertensionPatientsFold stimulationAbnormalities
2007
Renalase, a new renal hormone: its role in health and disease
Xu J, Desir GV. Renalase, a new renal hormone: its role in health and disease. Current Opinion In Nephrology & Hypertension 2007, 16: 373-378. PMID: 17565281, DOI: 10.1097/mnh.0b013e3281bd8877.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseEnd-stage renal diseaseKidney diseaseBlood pressureRenal hormoneRenal diseaseSalt-sensitive Dahl ratsExaggerated blood pressure responseBaseline blood pressureBlood pressure responseSympathetic nervous systemImportant therapeutic modalityRenalase deficiencyCardiovascular riskDahl ratsEssential hypertensionPlasma levelsCardiac functionRecombinant renalaseCardiovascular functionCardiovascular diseaseTherapeutic modalitiesHeart rateRenalase geneAdrenergic stress