Human renalase: a review of its biology, function, and implications for hypertension
Desir GV, Wang L, Peixoto AJ. Human renalase: a review of its biology, function, and implications for hypertension. International Journal Of Cardiology Cardiovascular Risk And Prevention 2012, 6: 417-426. PMID: 23107895, DOI: 10.1016/j.jash.2012.09.002.Peer-Reviewed Original ResearchConceptsMechanism of actionBlood pressureIschemic acute kidney injuryEnd-stage renal diseaseAcute kidney injuryHeart transplant recipientsChronic kidney diseaseAmbulatory blood pressureGlomerular filtration rateTarget organ injuryNormal control subjectsEnzyme-linked immunosorbent assayCatecholamine-like substancesRenalase deficiencyRenalase levelsKidney injuryTransplant recipientsRenal dopamineAcute administrationChronic administrationRenal diseaseKidney diseaseControl subjectsFiltration ratePlasma levelsRenalase Lowers Ambulatory Blood Pressure by Metabolizing Circulating Adrenaline
Desir GV, Tang L, Wang P, Li G, Sampaio‐Maia B, Quelhas‐Santos J, Pestana M, Velazquez H. Renalase Lowers Ambulatory Blood Pressure by Metabolizing Circulating Adrenaline. Journal Of The American Heart Association 2012, 1: e002634. PMID: 23130169, PMCID: PMC3487338, DOI: 10.1161/jaha.112.002634.Peer-Reviewed Original ResearchSympathetic nervous systemBlood pressureHypotensive effectNervous systemAmbulatory blood pressureTreatment of hypertensionBlood pressure regulationNovel therapeutic modalitiesPlasma epinephrineVasoactive hormonesRecombinant renalaseCardiac diseaseSystemic pressureTherapeutic modalitiesVivo administrationDopamine precursorΑ-methyldopaPressure regulationRenalaseEpinephrineSingle nucleotide polymorphismsHypertensionNorepinephrineUnique small moleculesSingle amino acid mutation